CC BY-NC-ND 4.0 · Endosc Int Open 2023; 11(09): E880-E884
DOI: 10.1055/a-2153-7210
Innovation forum

Long-term follow-up of the red density pilot trial: a basis for long-term prediction of sustained clinical remission in ulcerative colitis?

1   Department of Translational Research in Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium (Ringgold ID: RIN26657)
2   Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium (Ringgold ID: RIN74883)
,
Peter Bossuyt
2   Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium (Ringgold ID: RIN74883)
3   Gastroenterology, Imelda General Hospital, Bonheiden, Bonheiden, Belgium
,
João Pedro Guedelha Sabino
1   Department of Translational Research in Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium (Ringgold ID: RIN26657)
2   Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium (Ringgold ID: RIN74883)
,
Bram Verstockt
1   Department of Translational Research in Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium (Ringgold ID: RIN26657)
2   Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium (Ringgold ID: RIN74883)
,
Takao Makino
4   Pentax Life Care Division, Hoya Corporation Showanomori Technical Center Pentax Life Care Division, Akishima, Japan (Ringgold ID: RIN474220)
,
Severine Vermeire
1   Department of Translational Research in Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium (Ringgold ID: RIN26657)
2   Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium (Ringgold ID: RIN74883)
,
1   Department of Translational Research in Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium (Ringgold ID: RIN26657)
2   Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium (Ringgold ID: RIN74883)
› Author Affiliations
Supported by: Fonds Wetenschappelijk Onderzoek 1s82221N

Abstract

Red density (RD) technology is an automated operator-independent endoscopic scoring system for disease activity in ulcerative colitis (UC). In this retrospective analysis we aimed to assess the predictive value of the RD sore for sustained clinical remission. All 39 patients from the RD pilot trial were evaluated for clinical outcome in a 5-year period. The highest RD score was considered for Receiver operating characteristic (ROC) analysis to determine the cut-off of the RD for the composite endpoint of treatment failure (defined as mortality, colectomy, hospitalizations, flares and UC therapy changes). Statistical significance was considered P < 0.05. Reassessment of the RD score was possible in 36 patients. The composite endpoint was reached in 17 of 39 patients. ROC analysis for clinical remission showed a RD cut-off of 65, area under the ROC was 0.68, sensitivity of 0.71, and a specificity of 0.63. A RD score of ≥ 65 demonstrated a statistically non-significant increase in composite endpoint (hazard ratio 0.49 (95% confidence interval 0.1871-1.280); P = 0.1453). In conclusion, the RD score may be an independent predictor of clinical remission in patients with UC for the disease course up to 5 years, but results of the ongoing PROCEED-UC trial are to awaited for definite conclusions.

Supporting information



Publication History

Received: 29 March 2023

Accepted after revision: 10 August 2023

Accepted Manuscript online:
14 August 2023

Article published online:
27 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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