Parkinson-Krankheit – nicht-motorische Symptome für die Praxis

Wolfgang Jost

doi:10.1055/a-2127-6711

Neurologie up2date, Table of Contents

Neurologie up2date 2025; 08(01): 65-78
DOI: 10.1055/a-2127-6711

Bewegungsstörungen

Parkinson-Krankheit – nicht-motorische Symptome für die Praxis

Teil 1: Neuropsychiatrische und kardiovaskuläre Störungen

Wolfgang Jost

Abstract

All articles of this category

Nicht-motorische Symptome der Parkinson-Krankheit wie kognitive Einbußen, Depressionen, Schlafstörungen oder orthostatische Hypotonie treten oft bereits im Frühstadium auf und beeinflussen die Lebensqualität erheblich. Eine gezielte Diagnostik und individuell angepasste Therapie sind entscheidend, um diese Symptome zu erkennen und effektiv zu behandeln.

Full Text

References

Literatur
1 Storch A, Schneider CB, Wolz M. et al. Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications. Neurology 2013; 80: 800-809
2 Riedel O, Klotsche J, Spottke A. et al. Frequency of dementia, depression, and other neuropsychiatric symp¬toms in 1.449 outpatients with Parkinson’s disease. J Neurol 2010; 257: 107-1082
3 Barone P, Antonini A, Colosimo C. et al. The PRIAMO study. A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 2009; 24: 1641-1649
4 Gallagher DA, Schrag A. Psychosis, apathy, depression and anxiety in Parkinson’s disease. Neurobiol Dis 2012; 46: 581-589
5 Goldman JG, Holden SK, Litvan I. et al. Evolution of diagnostic criteria and assessments for Parkinson’s disease mild cognitive impairment. Mov Disord 2018; 33: 503-510
6 Emre M. Dementia in Parkinson’s disease: cause and treatment. Curr Opin Neurol 2004; 17: 399-404
7 Aarsland D, Bronnick K, Williams-Gray C. et al. Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis. Neurology 2010; 75: 1062-1069
8 Yarnall AJ, Breen DP, Duncan GW. et al. Characterizing mild cognitive impairment in incident Parkinson disease. Neurology 2014; 82: 308-316
9 Broeders M, de Bie RM, Velseboer DC. et al. Evolution of mild cognitive impairment in Parkinson disease. Neurology 2013; 81: 346-352
10 Kalbe E, Rehberg SP, Heber I. et al. Subtypes of mild cognitive impairment in patients with Parkinson’s disease: evidence from the LANDSCAPE study. J Neurol Neurosurg Psychiatry 2016; 87: 1099-1105
11 Szeto JYY, Walton CC, Rizos A. et al. Dementia in long-term Parkinson’s disease patients: a multicentre retrospective study. NPJ Parkinson Dis 2020; 6: 2
12 Postuma RB, Berg D, Stern M. et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 2015; 30: 1591-1601
13 Kempster PA, O’Sullivan SS, Holton JL. et al. Relationships between age and late progression of Parkinson’s disease: a clinic-pathological study. Brain 2010; 133: 1755-1762
14 Willis AW, Schootman M, Knug N. et al. Predictors of survival in patients with Parkinson disease. Arch Neurol 2012; 69: 601-607
15 Aarsland D, Brønnick K, Ehrt U. et al. Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatry 2007; 78: 36-42
16 Skorvanek M, Goldman JG, Jahanshahi M. et al. Global scales for cognitive screening in Parkinson’s disease: Critique and recommendations. Mov Disord 2018; 33: 208-218
17 Dalrymple-Alford JC, MacAskill MR, Nakas CT. et al. The MoCA: well-suited screen for cognitive impairment in Parkinson disease. Neurology 2010; 75: 1717-1725
18 Fengler S, Kessler J, Timmermann L. et al. Screening for cognitive impairment in Parkinson’s disease: Improving the diagnostic utility of the MoCA through subtest weighting. PLoS One 2016; 11: e0159318
19 Scheffels JF, Fröhlich L, Kalbe E. et al. Concordance of Mini-Mental State Examination, Montreal Cognitive Assessment and Parkinson Neuropsychometric Dementia Assessment in the classification of cognitive performance in Parkinson’s disease. J Neurol Sci 2020; 412: 116735
20 Schneider JS, Elm JJ, Parashos SA. et al. Predictors of cognitive outcomes in early Parkinson disease patients: The national institutes of health exploratory trials in Parkinson disease (NET-PD) experience. Parkinsonism Rel Disord 2010; 16: 507-512
21 Ehrt U, Broich K, Larsen JP. Use of drugs with anticholinergic effect and impact on cognition in Parkinson’s disease: a cohort study. J Neurol Neurosurg Psychiatry 2010; 81: 160-165
22 Witjas T, Kaphan E, Azulay JP. et al. Nonmotor fluctuations in Parkinson’s disease: frequent and disabling. Neurology 2002; 59: 408-413
23 Mattis PJ, Tang CC, Ma Y. et al. Network correlates of the cognitive response to levodopa in Parkinson disease. Neurology 2011; 77: 858-865
24 Emre M, Aarsland D, Albanese A. et al. Rivastigmine for dementia associated with Parkinson’s disease. N Engl J Med 2004; 351: 2509-2518
25 Ravina B, Putt M, Siderowf A. et al. Donepezil for dementia in Parkinson’s disease: a randomised, double blind, placebo controlled, crossover study. J Neurol Neurosurg Psychiatry 2005; 76: 934-939
26 Wesnes KA, McKeith I, Edgar C. et al. Benefits of rivastigmine on attention in dementia associated with Parkinson disease. Neurology 2005; 65: 1654-1656
27 Wood LD, Neumiller JJ, Setter SM. et al. Clinical review of treatment options for select nonmotor symptoms of Parkinson’s disease. Am J Geriatr Pharmacother 2010; 8: 294-315
28 Dubois B, Tolosa E, Katzenschlager R. et al. Donepezil in Parkinson’s disease dementia: a randomized, double-blind efficacy and safety study. Mov Disord 2012; 27: 1230-1238
29 Inzelberg R, Bonuccelli U, Schechtman E. et al. Association between amantadine and the onset of dementia in Parkinson’s disease. Mov Disord 2006; 21: 1375-1379
30 Emre M, Tsolaki M, Bonuccelli U. et al. Memantine for patients with Parkinson’s disease dementia or dementia with Lewy bodies: a randomized, double-blind, placebo-controlled trial. Lancet Neurol 2010; 9: 969-977
31 Goetz CG, Ouyang B, Negron A. et al. Hallucinations and sleep disorders in PD. Neurology 2010; 75: 1773-1779
32 Leroi I, Overshott R, Byrne EJ. et al. Randomized controlled trial of memantine in dementia associated with Parkinson’s disease. Mov Disord 2009; 24: 1217-1240
33 Seppi K, Weintraub D, Coelho M. et al. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson’s disease. Mov Disord 2011; 26: S42-S80
34 Kalbe E, Folkerts AK. Kognitives Training bei Parkinson-Patienten – eine neue Therapieoption?. Fortschr Neurol Psychiatr 2016; 84: S24-S35
35 Leung IH, Walton CC, Hallock H. et al. Cognitive training in Parkinson disease: A systematic review and meta-analysis. Neurology 2015; 85: 1843-1851
36 Ophey A, Giehl K, Rehberg S. et al. Effects of working memory training in patients with Parkinson’s disease without cognitive impairment: A randomized controlled trial. Parkinsonism Relat Disord 2020; 72: 13-22
37 Storch A, Ebersbach G, Fuchs G. et al. Depression bei Morbus Parkinson – Epidemiologie, Klinik, Pathophysiologie und Diagnostik. Fortschr Neurol Psych 2008; 76: 715-724
38 Goodarzi Z, Mrklas KJ, Roberts DJ. et al. Detecting depression in Parkinson disease. Neurology 2016; 87: 426-437
39 Martinez-Martin P, Leentjens AF, de Pedro-Cuesta J. et al. Accuracy of screening instruments for detection of neuropsychiatric syndromes in Parkinson’s disease. Mov Disord 2016; 31: 270-279
40 Schneider CB, Pilhatsch M, Rifati M. et al. Utility of the WHO-five well-being index as a screening tool for depression in Parkinson's disease. Mov Disord 2010; 25: 777-783
41 Goetz CG, Leurgans S, Pappert EJ. et al. Prospective longitudinal assessment of hallucinations in Parkinson’s disease. Neurology 2001; 57: 2078-2082
42 Mai AS, Chao Y, Xiao B. et al. Risk of suicidal ideation and behavior in individuals with Parkinson disease: a systematic review and meta-analysis. JAMA Neurol 2024; 81: 10-18
43 Nazem SN, Siderowf AD, Duda JE. et al. Suicidal and death ideation in Parkinson’s disease. Mov Disord 2008; 23: 1573-1579
44 Koo BB, Chow CA, Shah DR. et al. Demoralization in Parkinson disease. Neurology 2018; 90: e1613-e1617
45 Nagayama H, Maeda T, Uchiyama T. et al. Anhedonia and its correlation with clinical aspects in Parkinson’s disease. J Neurol Sci 2017; 372: 403-407
46 Pontone GM, Williams JR, Anderson KE. et al. Prevalence of anxiety disorders and enxiety subtypes in patients with Parkinson’s disease. Mov Disord 2009; 24: 1333-1338
47 Bazo-Alvarez JC, Nimmons D, Walters K. et al. Risk of Parkinson's disease in people with new onset anxiety over 50 years – incidence and associated features. Br J Gen Pract 2024; 74: e482-e488
48 Quelhas R, Costa M. Anxiety, depression, and quality of life in Parkinson’s disease. J Neuropsychiatry Clin Neurosci 2009; 21: 413-419
49 Storch A, Schneider C, Ebersbach G. et al. Depression beim idiopathischen Parkinson-Syndrom – Teil 2: Therapie und Management. Fortschr Neurol Psych 2010; 78: 456-467
50 Menza M, Dobkin RD, Marin H. et al. A controlled trial of antidepressants in patients with Parkinson disease and depression. Neurology 2009; 72: 886-892
51 Bonuccelli U, Meco G, Fabbrini G. et al. A non-comparative assessment of tolerability and efficacy of duloxetine in the treatment of depressed patients with Parkinson’s disease. Expert Opin Pharmacother 2012; 13: 2269-2280
52 Richard IH, McDermott MP, Kurlan R. et al. A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease. Neurology 2012; 78: 1229-1236
53 Weintraub D, Mayandadi S, Mamikonyan E. et al. Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson disease. Neurology 2010; 75: 448-455
54 Maruyama T. New treatment of depression in Parkinson’s disease. Int J Psychiatry Clin Pract 2003; 7: 25-27
55 Barone P, Scarzella L, Marconi R. et al. Pramipexole versus sertraline in the treatment of depression in Parkinson’s disease. J Neurol 2006; 253: 601-607
56 Szegedi A, Hillert A, Wetzel H. et al. Pramipexole, a dopamine agonist, in major depression: antidepressant effects and tolerability in an open-label study with multiple doses. Clin Neuropharmacol 1997; 20: 536-545
57 Leentjens AF. The role of dopamine agonists in the treatment of depression in patients with Parkinson’s disease: a systematic review. Drugs 2011; 71: 273-286
58 Dobkin RD, Menza M, Allen LA. et al. Cognitive-behavioral therapy for depression in Parkinson’s disease: A randomized, controlled trial. Am J Psychiatry 2011; 168: 1066-1074
59 Fénelon G, Alves G. Epidemiology of psychosis in Parkinson’s disease. J Neurol Sci 2010; 289: 12-17
60 Papapetropoulos S, Mash DC. Psychotic symptoms in Parkinson’s disease. From description to etiology. J Neurol 2005; 252: 753-764
61 Fenelon G, Mahieux F, Huon R. et al. Hallucinations in Parkinson’s disease: Prevalence, phenomenology and risk factors. Brain 2000; 123: 733-745
62 Lenka A, Ingalhalikar M, Shah A. et al. Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis. Neurology 2020; 94: e1876-e1884
63 Poletti M, Perugi G, Logi C. et al. Dopamine agonists and delusional jealousy in Parkinson’s disease: A cross-sectional prevalence study. Mov Disord 2012; 27: 1679-1682
64 Merims D, Shabtai H, Korczyn AD. et al. Antiparkinsonian medication is not a risk factor for the development of hallucinations in Parkinson’s disease. J Neural Transm 2004; 111: 1447-1453
65 Friedman JH. Parkinson’s disease psychosis 2010: a review article. Parkinsonism Rel Disord 2010; 16: 553-560
66 Pierelli F, Adipietro A, Soldati G. et al. Low dosage clozapine effects on L-dopa induced dyskinesias in parkinsonian patients. Acta Neurol Scand 1998; 97: 295-299
67 Pollak P, Tison F, Rascol O. et al. Clozapine in drug induced psychosis in Parkinson’s disease: a randomised, placebo controlled study with open follow up. J Neurol Neurosurg Psychiatry 2004; 75: 689-695
68 Kurlan R, Cummings J, Raman R. et al. Quetiapine for agitation or psychosis in patients with dementia and parkinsonism. Neurology 2007; 68: 1356-1363
69 Kitten AK, Hallowell SA, Saklad SR. et al. Pimavanserin: a novel drug approved to treat Parkinson’s disease psychosis. Innov Clin Neurosci 2018; 15: 16-22
70 Meltzer HY, Mills R, Revell S. et al. Pimavanserin, a serotonine(2A) receptor inverse agonist for the treatment of Parkinson’s diseases psychosis. Neuropsychopharmacology 2010; 35: 881-892
71 Cummings J, Isaacson S, Mills R. et al. Pimavanserin for patients with Parkinson’s disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet 2014; 383: 533-540
72 Markham A. Pimavanserin: First global approval. Drugs 2016; 76: 1053-1057
73 Evidente VGH, DeKarske D, Coate B. et al. The effects of treatment with pimavanserin on activities of daily living in patients with Parkinson's disease psychosis: a 16-week, single-arm, open-label study. Ther Adv Neurol Disord 2024; 17
74 Weintraub D, Chiang C, Kim HM. Association of antipsychotic use with mortality risk in patients with Parkinson disease. JAMA Neurol 2016; 73: 535-541
75 Santangelo G, Garramone F, Baiano C. et al. Personality and Parkinson’s disease: A meta-analysis. Parkinsonism Relat Disord 2018; 49: 67-74
76 Reiff J, Jost WH. Drug-induced impulse control disorders in Parkinson’s disease. J Neurol 2011; 258: S323-S327
77 O’Sullivan SS. Dopamine Dysregulation Syndrome: An overview of its epidemiology, mechanisms and management. CNS Drugs 2009; 23: 157-170
78 Cilia R, Siri C, Canesi M. et al. Dopamine dysregulation syndrome in Parkinson’s disease: from clinical and neuropsychological characterisation to management and long-term outcome. J Neurol Neurosurg Psychiatry 2014; 85: 311-318
79 Santangelo G, Barone B, Trojano L. et al. Pathological gambling in Parkinson’s disease. A comprehensive review. Parkinsonism Relat Disord 2013; 19: 645-653
80 Voon V, Mehta AR, Hallet M. Impulse control disorders in Parkinson’s disease: recent advances. Curr Opin Neurol 2011; 24: 324-330
81 Weintraub D, Koester J, Potenza MN. et al. Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Arch Neurol 2010; 67: 589-595
82 Barbosa PM, Grippe T, Lees AJ. et al. Compulsive sexual behaviour in Parkinson’s disease is associated with higher doses of levodopa. J Neurol Neurosurg Psychiatry 2018; 89: 1121-1123
83 Corvol JC, Artaud F, Cormier-Dequaire F. et al. Longitudinal analysis of impulse control disorders in Parkinson disease. Neurology 2018; 91: e189-e201
84 Garcia-Ruiz PJ, Martinez Castrillo JC, Alonso-Canovas A. et al. Impulse control disorder in patients with Parkinson’s diesase under dopamine agonist therapy: a multicentre study. J Neurol Neurosurg Psychiatry 2014; 85: 840-844
85 Soileau LG, Talbot NC, Storey NR. et al. Impulse control disorders in Parkinson's disease patients treated with pramipexole and ropinirole: a systematic review and meta-analysis. Neurol Sci 2024; 45: 1399-1408
86 Ray N, Strafella AP. Dopamine, reward, and frontostriatal circuitry in impulse control disorders in Parkinson’s disease: insights from functional imaging. Clin EEG Neurosci 2010; 41: 87-93
87 Weintraub D, Stewart S, Shea JA. et al. Validation of the questionnaire for impulsive-compulsive disorders in Parkinson’s disease (QUIP). Mov Disord 2009; 24: 1461-1467
88 Zesiewicz TA, Sullivan KL, Arnulf I. et al. Practice parameter: treatment of nonmotor symptoms of Parkinson disease: report of the quality standards subcommittee of the American academy of Neurology. Neurology 2010; 74: 924-931
89 Thomas A, Bonanni L, Gambi F. et al. Pathological gambling in Parkinson disease is reduced by amantadine. Ann Neurol 2010; 68: 400-404
90 Rajalingam R, Fasano A. Punding in Parkinson's disease: an update. Mov Disord Clin Pract 2023; 10: 1035-1047
91 Evans AH, Katzenschlager R, Paviour D. et al. Punding in Parkinson’s disease: its relation to the dopamine dysregulation syndrome. Mov Disord 2004; 19: 397-405