Deutsche Heilpraktiker-Zeitschrift 2023; 18(05): 24-27
DOI: 10.1055/a-2121-9899

Die Darm-Lungen-Achse

Andreas Rüffer


Lunge und Darm sind phylogenetisch sowie über das Schleimhautimmunnetzwerk miteinander verbunden. Daher wird auch von der Darm-Lungen-Achse gesprochen. In der Verbindung von Lunge und Darm spielt offensichtlich die Darmmikrobiota eine wichtige Rolle, insbesondere beim Asthma und bei Infekten der Atemwege. Bei der Behandlung von Asthma und Atemwegsinfekten ist unterstützend die Berücksichtigung der Darmmikrobiota diagnostisch und therapeutisch hilfreich.

Publication History

Article published online:
10 August 2023

© Karl F. Haug Verlag in Georg Thieme Verlag

  • Literatur

  • 1 Brandtzaeg P. Secretory IgA: Designed for anti-microbial defense. Frontiers in Immunol 2013; 4: Article 222
  • 2 Tokuhara D, Kurashima Y, Kamioka M. et al A comprehensive understanding of the gut mucosal immune system in allergic inflammation. Allergol Intern 2019; 68: 17-25
  • 3 Isolauri E. Development of healthy gut microbiota early in life. J Paed Child Health 2012; 48 (03) 1-6
  • 4 Arrieta MC, Stiemsma LT, Dimitriu PA et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Translat Med 2015; 307: 307ra152
  • 5 Takeuchi T, Miyauchi E, Kanaya T. et al Acetate differentially regulates IgA reactivity to commensal bacteria. Nature 2021; 595: 560-564
  • 6 Hufnagl K, Pali-Schöll I, Roth-Walter F. et al Dysbiosis of the gut and lung microbiome has a role in asthma. Sem Immunopathol 2020; 42: 75-93
  • 7 Benn CS, Thorsen P, Jensen JS. et al Maternal vaginal microflora during pregnancy and the risk of asthma hospitalization and use of antiasthma medication in early childhood. J Allergy Clin Immunol 2002; 110: 72-77
  • 8 Stokholm J, Thorsen J, Blaser MJ et al. Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma. Sci Transl Med 2020; 12: eaax9929
  • 9 Zven SE, Susi A, Mitre E. et al Association between use of multiple classes of antibiotic in infancy and allergic disease in childhood. JAMA Pediatr 2019; 174: 199-200
  • 10 Comberiati P, Di Cicco M, Paravati F. et al The role of gut and lung microbiota in susceptibility to tuberculosis. Int J Environ Res Public Health 2021; 18: 12220
  • 11 Shah T, Shah Z, Baloch Z. et al The role of microbiota in respiratory health and diseases, particulary in tuberculosis. Biomed Pharmacother 2021; 143: 112108
  • 12 Chhibber-Goel J, Gopinathan S, Sharma A. Interplay between severity of COVID-19 and the gut microbiome: Implications of bacterial co-infections? Gut Pathog. 2021; 13: 14
  • 13 Zhou A, Lei Y, Tang L. et al Gut microbiota: The emerging link to lung homeostasis and disease. J Bacteriol 2021; 203: e00454-20
  • 14 Meirlaen L, Levy EI, Vandenplas Y. Prevention and management with pro-, pre and synbiotics in children with asthma and allergic rhinitis: A narrative review. Nutr 2021; 13: 934
  • 15 Cruz CS, Ricci MF, Viera T. Gut microbiota modulation as a potential target for the treatment of lung infections. Front Pharmacol 2021; 12: 724033
  • 16 Barros R, Moreira A, Padrao P. et al Dietary patterns and asthma prevalence, incidence and control. Clin Exp Allergy 2015; 45: 1673-1680