PDF herunterladen
CC BY 4.0 · Arch Plast Surg 2023; 50(05): 478-487
DOI: 10.1055/a-2113-3084
Pediatric/Craniomaxillofacial/Head & Neck
Original Article

Consequence of Synthetic Bone Substitute Used for Alveolar Cleft Graft Reconstruction (Preliminary Clinical Study)

Rawaa Y. Al-Rawee
1   Department of Oral and Maxillofacial Surgery, Al-Salam Teaching Hospital. Mosul, Iraq
,
Bashar Abdul-Ghani Tawfeeq 
4   Department of Oral and Maxillofacial Surgery, Al-Noor University College, Mosul, Iraq
,
Ahmed Mothafar Hamodat 
3   Department of Pediatric Surgery, Al-Khansa Teaching Hospital, Mosul, Iraq
,
Zaid Salim Tawfek 
2   Paedo Ortho Prevention Department, Alnoor University College, Mosul, Iraq
› Institutsangaben Funding None.
› Weitere Informationen
   Lizenzen und Reprints

Abstract

Background The outcome of alveolar grafting with synthetic bone substitute (Osteon III) in various bone defect volumes is highlighted.

Methods A prospective study was accomplished on 55 patients (6–13 years of age) with unilateral alveolar bone cleft. Osteon III, consisting of hydroxyapatite and tricalcium phosphate, is used to reconstruct the defect. Alveolus defect diameter was calculated before surgery (V1), after 3 months (V2), and finally after 6 months (V3) postsurgery. In the t-test, a significant difference and correlation between V1, V2, and V3 are stated. A p-value of 0.01 is considered a significant difference between parameters.

Results The degree of cleft is divided into three categories: small (9 cases), medium (20 patients), and large (26 cases).The bone volume of the clefted site is divided into three steps: volume 1: (mean 18.1091 mm3); step 2: after 3 months, volume 2 resembles the amount of unhealed defect (mean 0.5109 mm3); and the final bone volume assessment is made after 6 months (22.5455 mm3). Both show statistically significant differences in bone volume formation.

Conclusion An alloplastic bone substitute can also be used as a graft material because of its unlimited bone retrieval. Osteon III can be used to reconstruct the alveolar cleft smoothly and effectively.

Keywords

alveolus grafting - synthetic bone substitute - secondary bone grafting - alveolar cleft - reconstruction

Authors' Contributions

R.Y.Al-R. conceived the ideas, led the writing, and collected the data. A.M.H. analyzed the data; and B.A.-G.T. Z.S.T collected the data with coordination with A.M.H. and approved the writing scientifically.


Ethical Approval

The study ethically approved by the Human Ethical Scientific Approval Application Form for Research of the Nineveh Health Directory, Ministry of Health, Iraq with licensed number 67/120.


Patient Consent

Authors can confirm that written informed consent obtained from study participants and clearly stated this in the manuscript.




Publikationsverlauf

Eingereicht: 28. April 2022

Angenommen: 15. Juni 2023

Accepted Manuscript online:
20. Juni 2023

Artikel online veröffentlicht:
31. August 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Kang NH. Current methods for the treatment of alveolar cleft. Arch Plast Surg 2017; 44 (03) 188-193
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 2 Lexer E. Die verwendung der freien knochenplastic nebst versuchen uber gelenkversteifung & gelenk-transplantation. Arth Klin Chir. 1908; 86: 939
    Google Scholar
  • 3 Schmid E. Die aufbauende kieferkammplastik. Ost J Stomat. 1954; 51: 582-583
    Google Scholar
  • 4 Eppley BL, van Aalst JA, Robey A, Havlik RJ, Sadove AM. The spectrum of orofacial clefting. Plast Reconstr Surg 2005; 115 (07) 101e-114e
    CrossrefPubMedGoogle Scholar
  • 5 Kyung H, Kang N. Management of alveolar cleft. Arch Craniofac Surg 2015; 16 (02) 49-52
    CrossrefPubMedGoogle Scholar
  • 6 Cohen M, Polley JW, Figueroa AA. Secondary (intermediate) alveolar bone grafting. Clin Plast Surg 1993; 20 (04) 691-705
    CrossrefPubMedGoogle Scholar
  • 7 Ullah H, Qayyum Z, Jamal M, Asim M, Khan MW. Donor site morbidity after bone harvesting from iliac crest for maxillofacial region. Pak Oral Dent J 2018; 38 (01) 21-25
    Google Scholar
  • 8 Khan MS, Shuang M, Liu XL, Xu S. , & Liang HF. Current concept in alveolar cleft management. Bangabandhu Sheikh Mujib Medical University Journal 2017; 10 (04) 195
    CrossrefGoogle Scholar
  • 9 Rawashdeh MA, Telfah H. Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity. Br J Oral Maxillofac Surg 2008; 46 (08) 665-670
    CrossrefPubMedGoogle Scholar
  • 10 Santiago PE, Schuster LA, Levy-Bercowski D. Management of the alveolar cleft. Clin Plast Surg 2014; 41 (02) 219-232
    CrossrefPubMedGoogle Scholar
  • 11 Dalkýz M, Ozcan A, Yapar M, Gökay N, Yüncü M. Evaluation of the effects of different biomaterials on bone defects. Implant Dent 2000; 9 (03) 226-235
    CrossrefPubMedGoogle Scholar
  • 12 Lew D, Farrell B, Bardach J, Keller J. Repair of craniofacial defects with hydroxyapatite cement. J Oral Maxillofac Surg 1997; 55 (12) 1441-1449 , discussion 1449–1451
    CrossrefPubMedGoogle Scholar
  • 13 Shirota T, Kurabayashi H, Ogura H, Seki K, Maki K, Shintani S. Analysis of bone volume using computer simulation system for secondary bone graft in alveolar cleft. Int J Oral Maxillofac Implants 2010; 39 (09) 904-908
    CrossrefPubMedGoogle Scholar
  • 14 Abyholm FE, Bergland O, Semb G. Secondary bone grafting of alveolar clefts. A surgical/orthodontic treatment enabling a non-prosthodontic rehabilitation in cleft lip and palate patients. Scand J Plast Reconstr Surg 1981; 15 (02) 127-140
    CrossrefPubMedGoogle Scholar
  • 15 Mahardawi B, Boonsiriseth K, Pairuchvej V, Wongsirichat N. Alveolar cleft bone grafting: factors affecting case prognosis. J Korean Assoc Oral Maxillofac Surg 2020; 46 (06) 409-416
    CrossrefPubMedGoogle Scholar
  • 16 Yaşar D. Bone Grafting – Recent Advances with Special References to Cranio-Maxillofacial Surgery. December 19, 2018. ISBN: 978-1-78984-883-0. PRINT ISBN: 978-1-78984-882-3 EBOOK ISBN: 978-1-83881-763-3.
    Google Scholar
  • 17 Sakkas A, Wilde F, Heufelder M, Winter K, Schramm A. Autogenous bone grafts in oral implantology-is it still a “gold standard”? A consecutive review of 279 patients with 456 clinical procedures. Int J Implant Dent 2017; 3 (01) 23
    CrossrefPubMedGoogle Scholar
  • 18 Almaiman M, Al-Bargi HH, Manson P. Complication of anterior iliac bone graft harvesting in 372 adult patients from may 2006 to may 2011 and a literature review. Craniomaxillofac Trauma Reconstr 2013; 6 (04) 257-266
    CrossrefPubMedGoogle Scholar
  • 19 de Rezende Barbosa GL, Wood JS, Pimenta LA, Maria de Almeida S, Tyndall DA. Comparison of different methods to assess alveolar cleft defects in cone beam CT images. Dentomaxillofac Radiol 2016; 45 (02) 20150332
    CrossrefPubMedGoogle Scholar
  • 20 Elhaddaoui R, Bahije L, Zaoui F, Rerhrhaye W. Timing of alveolar bone graft and sequences of canine eruption in cases of cleft lip and palate: a systematic review [in French]. Orthod Fr 2017; 88 (02) 193-198
    Google Scholar
  • 21 Du F, Wu H, Li H. et al. Bone marrow mononuclear cells combined with beta-tricalcium phosphate granules for alveolar cleft repair: a 12-month clinical study. Sci Rep 2017; 7 (01) 13773
    CrossrefPubMedGoogle Scholar
  • 22 Shavit E, Shavit I, Pinchasov D, Shavit D, Pinchasov G, Juodzbalys G. The use of tooth derived bone graft materials in sinus augmentation procedures: a systematic review. J Oral Maxillofac Res 2019; 10 (02) e1-e1
    CrossrefPubMedGoogle Scholar
  • 23 Goudy S, Lott D, Burton R, Wheeler J, Canady J. Secondary alveolar bone grafting: outcomes, revisions, and new applications. Cleft Palate Craniofac J 2009; 46 (06) 610-612
    CrossrefPubMedGoogle Scholar
  • 24 Cho-Lee G-Y, García-Díez E-M, Nunes R-A, Martí-Pagès C, Sieira-Gil R, Rivera-Baró A. Review of secondary alveolar cleft repair. Ann Maxillofac Surg 2013; 3 (01) 46-50
    CrossrefPubMedGoogle Scholar
  • 25 Jamjoom A, Cohen RE. Grafts for ridge preservation. J Funct Biomater 2015; 6 (03) 833-848
    CrossrefPubMedGoogle Scholar
  • 26 Sheikh Z, Sima C, Glogauer M. Bone replasubstitute materials and techniques used for achieving vertical alveolar bone augmentation. Materials (Basel) 2015; 8 (06) 2953-2993
    CrossrefGoogle Scholar
  • 27 Han-Seung K, Sangwoon L, Jae J. Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and Bioactivity. Nanomaterials 2021; 11: 213 . Accessed July 15, 2023 at: https://doi.org/10.3390/nano11010213
    CrossrefPubMedGoogle Scholar
  • 28 Wang M, Cheng X, Zhu W, Holmes B, Keidar M, Zhang LG. Design of biomimetic and bioactive cold plasma-modified nanostructured scaffolds for enhanced osteogenic differentiation of bone marrow-derived mesenchymal stem cells. Tissue Eng Part A 2014; 20 (5–6): 1060-1071
    CrossrefPubMedGoogle Scholar
  • 29 Perez RA, Ginebra MP. Injectable collagen/α-tricalcium phosphate cement: collagen-mineral phase interactions and cell response. J Mater Sci Mater Med 2013; 24 (02) 381-393
    CrossrefPubMedGoogle Scholar
  • 30 Akkouch A, Zhang Z, Rouabhia M. Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (L-lactide-co-ε-caprolactone) scaffold. J Biomater Appl 2014; 28 (06) 922-936
    CrossrefPubMedGoogle Scholar
  • 31 Battafarano G., Rossi M, De Martino V, Marampon F, Borro L, Secinaro A, Del Fattore A. Strategies for Bone Regeneration: From Graft to Tissue Engineering. Int. J. Mol. Sci 2021; 22: 1128
    CrossrefPubMedGoogle Scholar
  • 32 Melilli G, Carmagnola I, Tonda-Turo C, Pirri F, Ciardelli G, Sangermano M, Hakkarainen M, Chiappone A. DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels. Polymers 2020; 12 (08) 1655
    CrossrefPubMedGoogle Scholar
  • 33 Devi Y, Nagendra H, Shenoy S, Chatterjee K, Venkatesan J. Fucoidan-incorporated composite scaffold stimulates osteogenic differentiation of mesenchymal stem cells for bone tissue engineering. Drugs 2022; 20: 589
    Google Scholar
  • 34 Velasquez P, Luklinska ZB, Meseguer-Olmo L. et al. αTCP ceramic doped with dicalcium silicate for bone regeneration applications prepared by powder metallurgy method: in vitro and in vivo studies. J Biomed Mater Res A 2013; 101 (07) 1943-1954
    CrossrefPubMedGoogle Scholar
  • 35 Honma K, Kobayashi T, Nakajima T, Hayasi T. Computed tomographic evaluation of bone formation after secondary bone grafting of alveolar clefts. J Oral Maxillofac Surg 1999; 57 (10) 1209-1213
    CrossrefPubMedGoogle Scholar
  • 36 Trindade IK, Mazzottini R, Silva Filho OG, Trindade IEK, Deboni MCZ. Long-term radiographic assessment of secondary alveolar bone grafting outcomes in patients with alveolar clefts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 100 (03) 271-277
    CrossrefPubMedGoogle Scholar
  • 37 Tan AE, Brogan WF, McComb HK, Henry PJ. Secondary alveolar bone grafting–five-year periodontal and radiographic evaluation in 100 consecutive cases. Cleft Palate Craniofac J 1996; 33 (06) 513-518
    PubMedGoogle Scholar
  • 38 Enemark H, Sindet-Pedersen S, Bundgaard M. Long-term results after secondary bone grafting of alveolar clefts. J Oral Maxillofac Surg 1987; 45 (11) 913-919
    CrossrefPubMedGoogle Scholar
  • 39 Oryan A, Alidadi S, Moshiri A, Maffulli N. Bone regenerative medicine: classic options, novel strategies, and future directions. J Orthop Surg Res 2014; 9 (01) 18
    CrossrefPubMedGoogle Scholar
  • 40 Sohn HS, Oh JK. Review of bone graft and bone substitutes with an emphasis on fracture surgeries. Biomater Res 2019; 23: 9
    CrossrefPubMedGoogle Scholar
  • 41 Elsalanty ME, Genecov DG. Bone grafts in craniofacial surgery. Craniomaxillofac Trauma Reconstr 2009; 2 (03) 125-134
    CrossrefPubMedGoogle Scholar
  • 42 Buser Z, Brodke DS, Youssef JA. et al. Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review. J Neurosurg Spine 2016; 25 (04) 509-516
    CrossrefPubMedGoogle Scholar
  • 43 Valtanen RS, Yang YP, Gurtner GC, Maloney WJ, Lowenberg DW. Synthetic and bone tissue engineering graft substitutes: what is the future?. Injury 2021; 52 (Suppl. 02) S72-S77
    CrossrefPubMedGoogle Scholar
  • 44 Betz RR. Limitations of autograft and allograft: new synthetic solutions. Orthopedics 2002; 25 (05) s561-s570
    PubMedGoogle Scholar