Eine Vaskulitis kann in allen Organen auftreten, die Haut ist am häufigsten befallen.
Jede palpable Purpura ist praktisch beweisend für eine Kleingefäßvaskulitis. Potenzielle
Auslöser umfassen Medikamente, Infektionen, Kollagenosen und Malignome. Bei bis zu
50% der Fälle bleibt die Ätiologie unklar. Schwerpunkt dieses Artikels sind die relevantesten
kutanen Vaskulitiden in der täglichen Praxis, ihre diagnostische Abklärung und das
Therapiemanagement.
Abstract
Vasculitis is an inflammatory disease that can potentially affect all organs, with
the skin being the primary organ of manifestation. In this article, cutaneous vasculitis,
particularly small vessel vasculitis, will be described in more detail as it is the
predominant form of skin manifestation and mainly affects the postcapillary venules.
The etiology of cutaneous vasculitis can be diverse, including drugs, infections,
collagenoses and malignancies, with the exact cause remaining unclear in up to 50%
of cases.
Based on the 2012 Chapel Hill Consensus Conference (CHCC) and its 2018 addendum, the
different entities of cutaneous vasculitis are classified. It is important to consider
the severity of the disease and the underlying cause in order to adjust therapy management
and follow-up appropriately. Skin involvement can be either a manifestation of systemic
vasculitis, a variant of systemic vasculitis limited to the skin, or an isolated single
organ vasculitis affecting only the skin.
Accurate and careful assessment is essential to distinguish between these different
variants and to establish a systematic approach to the classification, evaluation
and management of patients with cutaneous vasculitis in clinical practice.
Schlüsselwörter
Kleingefäßvaskulitis - IgA - Non-IgA - Leukozytoklasie
Keywords
small vessel vasculitis - IgA - non-Iga - leukocytoclasia - postcapillary venules
