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Drug Res (Stuttg) 2023; 73(09): 481-490
DOI: 10.1055/a-2095-0826
Review

Repurposing Drugs: An Empowering Approach to Drug Discovery and Development

Drug repurposing for drug development
Sahil Kumar 
1   Pharmacology, ESIC Dental College and Hospital, New Delhi, India
,
Vandana Roy
2   Pharmacology, Maulana Azad Medical College, New Delhi, India
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Abstract

Drug discovery and development is a time-consuming and costly procedure that necessitates a substantial effort. Drug repurposing has been suggested as a method for developing medicines that takes less time than developing brand new medications and will be less expensive. Also known as drug repositioning or re-profiling, this strategy has been in use from the time of serendipitous drug discoveries to the modern computer aided drug designing and use of computational chemistry. In the light of the COVID-19 pandemic too, drug repurposing emerged as a ray of hope in the dearth of available medicines. Data availability by electronic recording, libraries, and improvements in computational techniques offer a vital substrate for systemic evaluation of repurposing candidates. In the not-too-distant future, it could be possible to create a global research archive for us to access, thus accelerating the process of drug development and repurposing. This review aims to present the evolution, benefits and drawbacks including current approaches, key players and the legal and regulatory hurdles in the field of drug repurposing. The vast quantities of available data secured in multiple drug databases, assisting in drug repurposing is also discussed.

Key words

Repurposing - repositioning - reprofiling - drug databases - drug development


Publication History

Received: 31 January 2023

Accepted: 09 May 2023

Article published online:
21 July 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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