Update Breast Cancer 2023 Part 1 – Early Stage Breast Cancer

Andreas D. Hartkopf; Tanja N. Fehm; Manfred Welslau; Volkmar Müller; Florian Schütz; Peter A. Fasching; Wolfgang Janni; Isabell Witzel; Christoph Thomssen; Milena Beierlein; Erik Belleville; Michael Untch; Marc Thill; Hans Tesch; Nina Ditsch; Michael P. Lux; Bahriye Aktas; Maggie Banys-Paluchowski; Cornelia Kolberg-Liedtke; Achim Wöckel; Hans-Christian Kolberg; Nadia Harbeck; Elmar Stickeler; Rupert Bartsch; Andreas Schneeweiss; Johannes Ettl; Rachel Würstlein; David Krug; Florin-Andrei Taran; Diana Lüftner

doi:10.1055/a-2074-0551

Geburtshilfe und Frauenheilkunde, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(06): 653-663
DOI: 10.1055/a-2074-0551

GebFra Science

Review

Update Mammakarzinom 2023 Teil 1 – Brustkrebs in frühen Krankheitsstadien

Artikel in mehreren Sprachen: English | deutsch

Autor*innen

Andreas D. Hartkopf

¹Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany (Ringgold ID: RIN27197)
Tanja N. Fehm

²Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany
Manfred Welslau

³Onkologie Aschaffenburg, Aschaffenburg, Germany
Volkmar Müller

⁴Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany
Florian Schütz

⁵Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany (Ringgold ID: RIN123168)
Peter A. Fasching

⁶Erlangen University Hospital, Department of Gynecology and Obstetrics; Comprehensive Cancer Center Erlangen EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (Ringgold ID: RIN207200)
Wolfgang Janni

¹Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany (Ringgold ID: RIN27197)
Isabell Witzel

⁷Klinik für Gynäkologie, Universitätsspital Zürich, Zürich, Switzerland (Ringgold ID: RIN31005)
Christoph Thomssen

⁸Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
Milena Beierlein

⁶Erlangen University Hospital, Department of Gynecology and Obstetrics; Comprehensive Cancer Center Erlangen EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (Ringgold ID: RIN207200)
Erik Belleville

⁹ClinSol GmbH & Co KG, Würzburg, Germany
Michael Untch

¹⁰Clinic for Gynecology and Obstetrics, Breast Cancer Center, Gynecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany (Ringgold ID: RIN62473)
Marc Thill

¹¹Department of Gynecology and Gynecological Oncology, Agaplesion Markus Krankenhaus, Frankfurt am Main, Germany (Ringgold ID: RIN84491)
Hans Tesch

¹²Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany
Nina Ditsch

¹³Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany (Ringgold ID: RIN39694)
Michael P. Lux

¹⁴Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany
Bahriye Aktas

¹⁵Department of Gynecology, University of Leipzig Medical Center, Leipzig, Germany
Maggie Banys-Paluchowski

¹⁶Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Cornelia Kolberg-Liedtke

¹⁷Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany (Ringgold ID: RIN39081)
Achim Wöckel

¹⁸Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
Hans-Christian Kolberg

¹⁹Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany
Nadia Harbeck

²⁰Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, München, Germany
Elmar Stickeler

²¹Department of Obstetrics and Gynecology, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany
Rupert Bartsch

²²Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria
Andreas Schneeweiss

²³National Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg, Germany
Johannes Ettl

²⁴Klinik für Frauenheilkunde und Gynäkologie, Klinikum Kempten, Klinikverbund Allgäu, Kempten, Germany (Ringgold ID: RIN27663)
Rachel Würstlein

²⁰Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, München, Germany
David Krug

²⁵Klinik für Strahlentherapie, Universitätsklinkum Schleswig-Holstein, Campus Kiel, Kiel, Germany (Ringgold ID: RIN15056)
Florin-Andrei Taran

²⁶Department of Gynecology and Obstetrics, University Hospital Freiburg, Freiburg, Germany
Diana Lüftner

²⁷Medical University of Brandenburg Theodor-Fontane, Immanuel Hospital Märkische Schweiz, Buckow, Germany

Abstract

Zusammenfassung

Mit den Zulassungen von Abemaciclib (monarchE-Studie) und Olaparib (OlympiA-Studie) in der adjuvanten Therapiesituation haben sich die Therapiestandards bei der Behandlung von Patientinnen mit Mammakarzinom in Frühstadien seit Langem deutlich verändert. Somit übertragen sich einige vielfältige Entwicklungen aus der metastasierten Therapiesituation langsam in die adjuvante. Kürzlich ist auch die NATALEE-Studie als positiv berichtet worden.

Weitere Therapiestudien mit Substanzen, die in der metastasierten Situation etabliert sind, werden zurzeit durchgeführt. Dies sind z. B. die DESTINY Breast05-Studie mit Trastuzumab-Deruxtecan und die SASCIA-Studie mit Sacituzumab Govitecan.

In dieser Übersichtsarbeit werden die neuesten Entwicklungen der letzten Monate zusammengefasst und in den jeweiligen Kontext eingeordnet.

Schlüsselwörter

Brustkrebs - Frühstadium - adjuvante Therapie - neoadjuvante Therapie - endokrine Therapie - Biomarker

Volltext

Referenzen

References/Literatur
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