Update Breast Cancer 2022 Part 5 – Early Stage Breast Cancer

Tanja N. Fehm; Manfred Welslau; Volkmar Müller; Diana Lüftner; Florian Schütz; Peter A. Fasching; Wolfgang Janni; Christoph Thomssen; Isabell Witzel; Milena Beierlein; Erik Belleville; Michael Untch; Marc Thill; Hans Tesch; Nina Ditsch; Michael P. Lux; Bahriye Aktas; Maggie Banys-Paluchowski; Cornelia Kolberg-Liedtke; Andreas D. Hartkopf; Achim Wöckel; Hans-Christian Kolberg; Nadia Harbeck; Elmar Stickeler

doi:10.1055/a-2018-9053

Geburtshilfe und Frauenheilkunde, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(03): 289-298
DOI: 10.1055/a-2018-9053

GebFra Science

Review

Update Breast Cancer 2022 Part 5 – Early Stage Breast Cancer

Artikel in mehreren Sprachen: English | deutsch

Tanja N. Fehm

¹Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Manfred Welslau

²Onkologie Aschaffenburg, Aschaffenburg, Germany

,

Volkmar Müller

³Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Diana Lüftner

⁴Immanuel Hospital Märkische Schweiz, Buckow; Medical University of Brandenburg Theodor-Fontane, Brandenburg, Germany

,

Florian Schütz

⁵Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany

,

Peter A. Fasching

⁶Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Wolfgang Janni

⁷Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Christoph Thomssen

⁸Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

,

Isabell Witzel

³Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Milena Beierlein

⁶Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Erik Belleville

⁹ClinSol GmbH & Co. KG, Würzburg, Germany

,

Michael Untch

¹⁰Clinic for Gynecology and Obstetrics, Breast Cancer Center, Gynecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany

,

Marc Thill

¹¹Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt, Germany

,

Hans Tesch

¹²Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany

,

Nina Ditsch

¹³Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany

,

Michael P. Lux

¹⁴Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany

,

Bahriye Aktas

¹⁵Department of Gynecology, University of Leipzig Medical Center, Leipzig, Germany

,

Maggie Banys-Paluchowski

¹⁶Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany

,

Cornelia Kolberg-Liedtke

¹⁷Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany

,

Andreas D. Hartkopf

⁷Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Achim Wöckel

¹⁸Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

,

Hans-Christian Kolberg

¹⁹Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Nadia Harbeck

²⁰Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany

,

Elmar Stickeler

²¹Department of Obstetrics and Gynecology, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany

› Institutsangaben

Abstract

The treatment of patients with early stage breast cancer has changed in recent years due to the introduction of pembrolizumab, olaparib, and abemaciclib. These and other drugs with the same class of active ingredient are currently in trial for various indications. This review article summarizes the latest results that have either been presented at major conferences such as the ESMO 2022 or published recently in international journals. This includes reports on newly discovered breast cancer genes, atezolizumab in neoadjuvant therapy in HER2-positive patients, long-term data from the APHINITY study, and on how preoperative peritumoral application of local anesthetics can influence the prognosis. We also present solid data on dynamic Ki-67 from the ADAPT studies.

Key words

breast cancer - surgery - chemotherapy - therapy standard

Volltext

Referenzen

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