Abstract
Background Lung cancer incidence has greatly increased over the past century. Moreover, the
lung is the most common site of metastatic involvement. Despite improvements in the
diagnosis and treatment of lung malignancies, patient prognosis is still unsatisfactory.
Locoregional chemotherapeutic techniques for the treatment of lung malignancies are
the current focus of research. The aim of this review article is to present different
locoregional intravascular techniques and their treatment principles and to assess
the pros and cons of each of them as a palliative and neoadjuvant treatment method
in the treatment of lung malignancy.
Method The different methods for the treatment of malignant lung lesions such as isolated
lung perfusion (ILP), selective pulmonary artery perfusion (SPAP), transpulmonary
chemoembolization (TPCE), bronchial artery infusion (BAI), bronchioarterial chemoembolization
(BACE), and intraarteriel chemoperfusion (IACP) are evaluated comparatively.
Results Locoregional intravascular chemotherapy procedures are proving to be promising treatment
options in the management of malignant lung tumors. In order to achieve optimal results,
the locoregional technique should be used to achieve the highest possible uptake of
the chemotherapeutic agent into the target tissue with rapid systemic clearance.
Conclusion Among the various treatment options for lung malignancies, TPCE is the best evaluated
treatment concept. However, further studies are necessary to define the optimal treatment
concept with the best clinical outcomes.
Key Points
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There are various intravascular chemotherapy methods for the treatment of lung malignancies.
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Transpulmonary chemoembolization (TPCE) is currently the most extensively evaluated
treatment method for lung malignancies.
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Thermoablation after neoadjuvant chemoperfusion is a promising therapy for treating
lung malignancies.
Citation Format
Key words
chemoembolization - interventional procedures - pulmonary metastases - lung cancer
- locoregional techniques
