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CC BY-NC-ND 4.0 · Hamostaseologie 2023; 43(04): 281-288
DOI: 10.1055/a-1984-7210
Original Article

Comparison of Performances among Four Bleeding-Prediction Scores in Elderly Cancer Patients with Venous Thromboembolism

Authors

  • Shaozhi Xi‡   *

    1   Department of Comprehensive Surgery, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China
    2   Department of Geriatrics, Aerospace Center Hospital (ASCH), Beijing, China

  • Chaoyang Liu‡   *

    1   Department of Comprehensive Surgery, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China

  • Shuihua Yu

    2   Department of Geriatrics, Aerospace Center Hospital (ASCH), Beijing, China

  • Jingxuan Qiu

    2   Department of Geriatrics, Aerospace Center Hospital (ASCH), Beijing, China

  • Shuibo He

    2   Department of Geriatrics, Aerospace Center Hospital (ASCH), Beijing, China

  • Zhong Yi

    2   Department of Geriatrics, Aerospace Center Hospital (ASCH), Beijing, China
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Abstract

The performances of RIETE, VTE-BLEED, SWITCO65 + , and Hokusai-VTE scores for predicting major bleeding events in hospitalized elderly cancer patients with venous thromboembolism (VTE) have not been evaluated. This study validated the performances of these scoring systems in a cohort of elderly cancer patients with VTE. Between June 2015 and March 2021, a total of 408 cancer patients (aged ≥ 65 years) with acute VTE were consecutively enrolled. The overall rates of in-hospital major bleeding and clinically relevant bleeding (CRB) were 8.3% (34/408) and 11.8% (48/408), respectively. RIETE score could categorize patients with increasing rate of major bleeding and CRB into low-/intermediate- and high-risk categories (7.1 vs. 14.1%, p = 0.05 and 10.1 vs. 19.7%, p = 0.02, respectively). The discriminative power of the four scores for predicting major bleeding was poor to moderate, indicated by areas under the receiver operating characteristic curves (0.45 [95% confidence interval, CI: 0.35–0.55] for Hokusai-VTE, 0.54 [95% CI: 0.43–0.64] for SWITCO65 + , 0.58 [95% CI: 0.49–0.68] for VTE-BLEED, and 0.61 [95% CI: 0.51–0.71] for RIETE). RIETE score might be used to predict major bleeding in hospitalized elderly cancer patients with acute VTE.

Keywords

cancer - venous thromboembolism - elderly patients - bleeding-prediction score

* Shaozhi Xi and Chaoyang Liu as co-first authors contribute equally to the manuscript.




Publication History

Received: 11 July 2022

Accepted: 21 November 2022

Article published online:
03 May 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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