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Horm Metab Res 2023; 55(01): 25-30
DOI: 10.1055/a-1971-8781
Original Article: Endocrine Care

The Clinical Characteristics and Outcomes of COVID-19 Patients with Pre-Existing Thyroid Dysfunction: A Nationwide Study

Autoren

  • Mustafa Sahin

    1   Ankara University, Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey

  • Ibrahim Demirci

    2   University of Health Sciences, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey

  • Cem Haymana

    2   University of Health Sciences, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey

  • Ilker Tasci

    3   University of Health Sciences, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital, Department of Internal Medicine, Ankara, Turkey

  • Rıfat Emral

    1   Ankara University, Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey

  • Erman Cakal

    4   University of Health Sciences, Faculty of Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey

  • Ugur unluturk

    5   Hacettepe University, Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey

  • Ilhan Satman

    6   Istanbul University, Faculty of Medicine, Department of Endocrinology and Metabolism, Istanbul, Turkey

  • Tevfik Demir

    7   Dokuz Eylul University, Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey

  • Naim Ata

    8   Department of Strategy Development, Ministry of Health, Ankara, Turkey

  • Derun Ertugrul

    9   University of Health Sciences, Faculty of Medicine, Kecioren Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey

  • Aysegul Atmaca

    10   Ondokuz Mayis University, Faculty of Medicine, Department of Endocrinology and Metabolism, Samsun, Turkey

  • Serpil Salman

    11   Medica Clinic, Department of Endocrinology and Metabolism, Istanbul, Turkey

  • Ibrahim Sahin

    12   Inonu University, Faculty of Medicine, Department of Endocrinology and Metabolism, Malatya, Turkey

  • Selcuk Dagdelen

    4   University of Health Sciences, Faculty of Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey

  • Osman Celik

    13   Public Hospitals General Directorate, Republic of Turkey, Ministry of Health, Ankara, Turkey

  • Murat Caglayan

    14   Ankara Provincial Health Directorate, Ankara, Turkey

  • Alper Sonmez

    2   University of Health Sciences, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey

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Abstract

To which extent the pre-existing hypothyroidism or hyperthyroidism has an impact on coronavirus infection 2019 (COVID-19) outcomes remains unclear. The objective of this study was to evaluate COVID-19 morbidity and mortality in patients with pre-existing thyroid dysfunction. A retrospective cohort of patients with a polymerase chain reaction (PCR)-confirmed COVID-19 infection (n=14 966) from March 11 to May 30, 2020, was established using the database of the Turkish Ministry of Health. We compared the morbidity and mortality rates of COVID-19 patients with pre-existing hypothyroidism (n=8813) and hyperthyroidism (n=1822) to those patients with normal thyroid function (n=4331). Univariate and multivariate regression analyses were performed to identify the factors associated with mortality. Mortality rates were higher in patients with hyperthyroidism (7.7%) and hypothyroidism (4.4%) than those with normal thyroid function (3.4%) (p<0.001 and p=0.008, respectively). Pre-existing hyperthyroidism was significantly associated with an increased risk of mortality (OR 1.54; 95% CI, 1.02–2.33; p=0.042) along with advanced age, male gender, lymphopenia and chronic kidney disease (p<0.001 for all). Although a potential trend was noted, the association between pre-existing hypothyroidism and mortality was not significant (OR 1.36; 95% CI, 0.99–1.86; p=0.055). In conclusion, this study showed an association between pre-existing hyperthyroidism with higher COVID-19 mortality. A potential trend towards increased mortality was also observed for hypothyroidism. The risk was more pronounced in patients with hyperthyroidism.

Key words

thyroid dysfunction - hyperthyroidism - TSH - COVID-19 - mortality - ICU admission

Supplementary Material



Publikationsverlauf

Eingereicht: 11. Mai 2022

Angenommen nach Revision: 03. November 2022

Accepted Manuscript online:
03. November 2022

Artikel online veröffentlicht:
09. Dezember 2022

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