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veterinär spiegel 2023; 33(01): 22-27
DOI: 10.1055/a-1971-0933
Nutztiere & Pferde

Neues aus Empirie und Wissenschaft – wie Impfungen das Immunsystem trainieren

Hans-Joachim Schuberth
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Impfungen sollen Antigen-spezifische Zellen und Antikörper sowie Gedächtniszellen des adaptiven Immunsystems induzieren und auch Zellen des angeborenen Immunsystems anregen. Wir beleuchten die trainierende Wirkung bestimmter Impfstoffe – insbesondere für veterinärmedizinisch relevante Spezies.

Publication History

Article published online:
16 March 2023

© 2023. Thieme. All rights reserved.

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  • Literatur

  • 1 Laupeze B, Del Giudice G, Doherty MT. et al. Vaccination as a preventative measure contributing to immune fitness. NPJ Vaccines 2021; 6: 93
    CrossrefPubMedGoogle Scholar
  • 2 Bekkering S, Domínguez-Andrés J, Joosten L. et al. Trained Immunity: Reprogramming Innate Immunity in Health and Disease. Annu Rev Immunol 2021; 39: 667-693
    CrossrefPubMedGoogle Scholar
  • 3 Netea MG, Dominguez-Andres J, Barreiro LB. et al. Defining trained immunity and its role in health and disease. Nat Rev Immunol 2020; 20: 375-388
    CrossrefPubMedGoogle Scholar
  • 4 Chavakis T, Mitroulis I, Hajishengallis G. Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation. Nature immunology 2019; 20: 802-811
    CrossrefPubMedGoogle Scholar
  • 5 Aaby P, Benn CS. Developing the concept of beneficial non-specific effect of live vaccines with epidemiological studies. Clin Microbiol Infect 2019; 25: 1459-1467
    CrossrefPubMedGoogle Scholar
  • 6 Giamarellos-Bourboulis EJ, Tsilika M, Moorlag S. et al. Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly. Cell 2020; 183: 315-323 e9
    CrossrefPubMedGoogle Scholar
  • 7 Messina NL, Pittet LF, Gardiner K. et al. Neonatal Bacille Calmette-Guerin Vaccination and Infections in the First Year of Life: The MIS BAIR Randomized Controlled Trial. J Infect Dis 2021; 224: 1115-1127
    CrossrefPubMedGoogle Scholar
  • 8 Noale M, Trevisan C, Maggi S. et al. The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey. Vaccines (Basel) 2020; 8
    Google Scholar
  • 9 Singh S, Maurya RP, Singh RK. “Trained immunity” from Mycobacterium spp. exposure or BCG vaccination and COVID-19 outcomes. PLoS Pathog 2020; 16: e1008969
    CrossrefPubMedGoogle Scholar
  • 10 Debisarun PA, Gossling KL, Bulut O. et al. Induction of trained immunity by influenza vaccination – impact on COVID-19. PLoS Pathog 2021; 17: e1009928
    CrossrefPubMedGoogle Scholar
  • 11 Juste RA, Alonso-Hearn M, Garrido JM. et al. Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria. PLoS One 2016; 11: e0165607
    CrossrefPubMedGoogle Scholar
  • 12 Guerra-Maupome M, Vang DX, McGill JL. Aerosol vaccination with Bacille Calmette-Guerin induces a trained innate immune phenotype in calves. PLoS One 2019; 14: e0212751
    CrossrefPubMedGoogle Scholar
  • 13 Schunemann LM, Schuberth HJ. Non-classical monocytes contribute to innate immune training in cattle. Innate Immun 2022; 28: 199-210
    CrossrefPubMedGoogle Scholar
  • 14 Shalaby MA, Saleh SM, el-Atrash S. et al. Application of Corynebacterium cutis lysate as an immune stimulant in cattle. Mol Biother 1992; 4: 147-150
    PubMedGoogle Scholar
  • 15 Byrne KA, Loving CL, McGill JL. Innate Immunomodulation in Food Animals: Evidence for Trained Immunity?. Front Immunol 2020; 11: 1099
    CrossrefPubMedGoogle Scholar
  • 16 Jensen KJ, Hansen MS, Heegaard PMH. et al. The Effect of Inactivated Mycobacterium Paratuberculosis Vaccine on the Response to a Heterologous Bacterial Challenge in Pigs. Front Immunol 2019; 10: 1557
    CrossrefPubMedGoogle Scholar
  • 17 Paris S, Chapat L, Pasin M. et al. β-Glucan-Induced Trained Immunity in Dogs. Front Immunol 2020; 11: 566893
    CrossrefPubMedGoogle Scholar
  • 18 Paris S, Chapat L, Martin-Cagnon N. et al. β-Glucan as Trained Immunity-Based Adjuvants for Rabies Vaccines in Dogs. Front Immunol 2020; 11: 564497
    CrossrefPubMedGoogle Scholar
  • 19 Ilg T. Investigations on the molecular mode of action of the novel immunostimulator ZelNate: Activation of the cGAS-STING pathway in mammalian cells. Mol Immunol 2017; 90: 182-189
    CrossrefPubMedGoogle Scholar
  • 20 Woolums AR, Karisch BB, Parish JA. et al. Effect of a DNA-based immunostimulant on growth, performance, and expression of inflammatory and immune mediators in beef calves abruptly weaned and introduced to a complete ration. J Anim Sci 2019; 97: 111-121
    CrossrefPubMedGoogle Scholar
  • 21 Nosky B, Biwer J, Alkemade S. et al. Effect of a non-specific immune stimulant (Amplimune™) on the health and production of light feedlot calves. J Dairy Vet Anim Res 2017; 6: 00179
    Google Scholar
  • 22 Schuberth H-J. Immunmodulation und Impfung: Die Beeinflussung von Immunantworten in Prophylaxe und Therapie. Tierärztl Umsch KT 2020; 244-247
    Google Scholar
  • 23 Sánchez-Ramón S, Conejero L, Netea MG. et al. Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations. Front Immunol 2018; 9: 2936
    CrossrefPubMedGoogle Scholar
  • 24 Shann F. The non-specific effects of vaccines. Archives of disease in childhood 2010; 95: 662-667
    CrossrefPubMedGoogle Scholar
  • 25 Amir M, Zeng MY. Immune imprinting in utero. Science 2021; 373: 967-968
    CrossrefPubMedGoogle Scholar