Rhabdomyolysis Caused by Hypothyroidism: Research
                    Progress

Qingju Zhou; Bin Li; Xin Tian

doi:10.1055/a-1951-1646

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2022; 54(11): 731-735
DOI: 10.1055/a-1951-1646

Review

Rhabdomyolysis Caused by Hypothyroidism: Research Progress

Qingju Zhou

¹Department of Health Management Center, Chongqing General Hospital, Chongqing, China

,

Bin Li

¹Department of Health Management Center, Chongqing General Hospital, Chongqing, China

,

Xin Tian

²Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China

› Institutsangaben

Abstract

Rhabdomyolysis (RM) refers to the clinical syndrome caused by the release of intracellular substances into the extracellular fluid and blood circulation after rhabdomyocyte destruction due to various etiologies. In severe cases, RM can lead to life-threatening conditions such as acute kidney injury. Hypothyroidism is a rare cause of RM that can lead to missed diagnosis or misdiagnosis, and the condition worsens in the absence of timely and effective treatment. Herein, reported cases of RM caused by hypothyroidism are summarized, and clinical diagnosis and treatment recommendations are proposed to facilitate early identification and treatment of the disease.

Key words

hypothyroidism - thyroid - rhabdomyolysis - creatine kinase - acute kidney injury

Volltext

Referenzen

References
1 Warren JD, Blumbergs PC, Thompson PD.. Rhabdomyolysis: a review. Muscle Nerve 2002; 25: 332347
2 Huerta-Alardín AL, Varon J, Marik PE.. Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians. Crit Care (London, England) 2005; 9: 158-169
3 Khan FY.. Rhabdomyolysis: a review of the literature. Neth J Med 2009; 67: 272-283
4 Janjua I, Bashir T, Haq MZU. et al. Severe hypothyroidism presenting with rhabdomyolysis in a young patient. Cureus 2021; 13: e13993
5 Stanley M, Chippa V, Aeddula NR. et al. Rhabdomyolysis. In: StatPearls. Treasure Island (FL): StatPearls Publishing LLC; 2022
6 Zutt R, van der Kooi AJ, Linthorst GE. et al. Rhabdomyolysis: review of the literature. Neuromuscul Disord 2014; 24: 651-659
7 Schwartz L, Bishop R, Le J. et al. Acute flaccid paralysis in an 11-year-old. Pediatr Emerg Care 2021; 37: e348-e350
8 Cabral BMI, Edding SN, Portocarrero JP. et al. Rhabdomyolysis. Dis-a-Mon 2020; 66: 101015
9 McMahon GM, Zeng X, Waikar SS.. A risk prediction score for kidney failure or mortality in rhabdomyolysis. JAMA Intern Med 2013; 173: 1821-1828
10 Aleckovic-Halilovic M, Pjanic M, Mesic E.. From quail to earthquakes and human conflict: a historical perspective of rhabdomyolysis. Clin Kidney J 2021; 14: 1088-1096
11 Bywaters EG, Beall D.. Crush injuries with impairment of renal function. 1941. J Am Soc Nephrol 1998; 9: 322-332
12 Smith LH, Post RS, Teschan PE. et al. Post-traumatic renal insufficiency in military casualties. II. Management, use of an artificial kidney, prognosis. Am J Med 1955; 18: 187198
13 Stone WJ, Knepshield JH.. Post-traumatic acute renal insufficiency in Vietnam. Clin Nephrol 1974; 2: 186-190
14 Bosch X, Poch E, Grau JM.. Rhabdomyolysis and acute kidney injury. The N Eng. J Med 2009; 361: 62-72
15 Ghayur A, Elahi Q, Patel C. et al. Rhabdomyolysis-induced acute kidney injury in a patient with non-compliance to levothyroxine therapy. Endocrinol Diabetes Metab Case Rep 2021; 21-0034 Online ahead of print
16 Kodadek L, Carmichael IiSP.. Rhabdomyolysis: an American association for the surgery of trauma critical care committee clinical consensus document. Trauma Surg Acute Care Open 2022; 7: e000836
17 Li SF, Zapata J, Tillem E.. The prevalence of false-positive cardiac troponin I in ED patients with rhabdomyolysis. Am J Emerg Med 2005; 23: 860-863
18 Poels PJ, Gabreëls FJ.. Rhabdomyolysis: a review of the literature. Clin Neurol Neurosurg 1993; 95: 175-192
19 Hino I, Akama H, Furuya T. et al. Pravastatin-induced rhabdomyolysis in a patient with mixed connective tissue disease. Arthrit Rheum 1996; 39: 1259-1260
20 Brown CV, Rhee P, Chan L. et al. Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference?. J Trauma 2004; 56: 1191-1196
21 Mannix R, Tan ML, Wright R. et al. Acute pediatric rhabdomyolysis: causes and rates of renal failure. Pediatrics 2006; 118: 2119-2125
22 Garber JR, Cobin RH, Gharib H. et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American association of clinical endocrinologists and the American thyroid association. Thyroid 2012; 22: 1200-1235
23 Shan Z, Chen L, Lian X. et al. Iodine status and prevalence of thyroid disorders after introduction of mandatory universal salt iodization for 16 years in China: a cross-sectional study in 10 cities. Thyroid 2016; 26: 1125-1130
24 Andersson M, de Benoist B, Delange F. et al. Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical Consultation. Pub Health Nutr 2007; 10: 1606-1611
25 Bensenor IM, Olmos RD, Lotufo PA.. Hypothyroidism in the elderly: diagnosis and management. Clin Interven Aging 2012; 7: 97-111
26 Almandoz JP, Gharib H.. Hypothyroidism: etiology, diagnosis, and management. Med Clin North Am 2012; 96: 203-221
27 Ladenson PW, Singer PA, Ain KB. et al. American thyroid association guidelines for detection of thyroid dysfunction. Arch Intern Med 2000; 160: 1573-1575
28 Duyff RF, Van den Bosch J, Laman DM. et al. Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study. J Neurol Neurosurg Psychiatry 2000; 68: 750-755
29 Halverson PB, Kozin F, Ryan LM. et al. Rhabdomyolysis and renal failure in hypothyroidism. Ann Intern Med 1979; 91: 57-58
30 Hochberg MC, Koppes GM, Edwards CQ. et al. Hypothyroidism presenting as a polymyositis-like syndrome. Report of two cases. Arthritis Rheum 1976; 19: 1363-1366
31 Riggs JE.. Acute exertional rhabdomyolysis in hypothyroidism: the result of a reversible defect in glycogenolysis?. Military Med 1990; 155: 171-172
32 Sekine N, Yamamoto M, Michikawa M. et al. Rhabdomyolysis and acute renal failure in a patient with hypothyroidism. Intern Med (Tokyo, Japan) 1993; 32: 269-271
33 Salehi N, Agoston E, Munir I. et al. Rhabdomyolysis in a patient with severe hypothyroidism. Am J Case Rep 2017; 18: 912-918
34 Ren L, Wei C.. A case report of rhabdomyolysis and osteofascial compartment syndrome in a patient with hypothyroidism and diabetes. BMC Endocr Disord 2021; 21: 212
35 Kuo HT, Jeng CY.. Overt hypothyroidism with rhabdomyolysis and myopathy: a case report. Chin Med J 2010; 123: 633-637
36 Kisakol G, Tunc R, Kaya A.. Rhabdomyolysis in a patient with hypothyroidism. Endocr J 2003; 50: 221-223
37 Manappallil RG, Muralidharan R, Shalu S. et al. Hashimoto's thyroiditis aggravated by goitrogenic diet presenting as rhabdomyolysis worsened by alcohol intake. BMJ Case Rep 2021; 14: e243385
38 Gurala D, Rajdev K.. Rhabdomyolysis in a young patient due to hypothyroidism without any precipitating factor. Case Rep Endocrinol 2019; 2019; 4210431
39 Haynes RB, Montague P, Oliver T. et al. Interventions for helping patients to follow prescriptions for medications. The Cochrane database of systematic reviews 2000; Cd000011
40 Comak E, Koyun M, Kiliçarslan-Akkaya B. et al. Severe rhabdomyolysis and acute renal failure in an adolescent with hypothyroidism. Turk J Pediatr 2011; 53: 586-589
41 Baghi MA, Sirajudeen J, Naushad VA. et al. Severe hypothyroidism-induced rhabdomyolysis: a case report. Clin Case Rep 2021; 9: e05107
42 Bagley WH, Yang H, Shah KH.. Rhabdomyolysis. Intern Emerg Med 2007; 2: 210-218
43 Petejova N, Martinek A.. Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review. Crit Care (London, England) 2014; 18: 224
44 Varalakshmi DB, Ram R.. Rhabdomyolysis due to hypothyroidism without any precipitating factor. Trop Doct 2020; 50: 273-274
45 Cao LL, Gaffney LK, Marcus C.. Hypokalemia-induced rhabdomyolysis in a child with autism affected by the COVID-19 pandemic. J Dev Behav Pediatr 2021; 43: e356-e360
46 Allison RC, Bedsole DL.. The other medical causes of rhabdomyolysis. The Am J Med Sci 2003; 326: 79-88
47 Horwitz H, Woeien VA, Petersen LW. et al. Hypokalemia and rhabdomyolysis. J Pharmacol Pharmacother 2015; 6: 98-99
48 Reakes E, Drak D, Gracey D.. A suspected case of hyponatraemia induced rhabdomyolysis: a case report. BMC Nephrol 2022; 23: 180