C–H bond functionalization is one of the most effective strategies for the rapid synthesis
of cyclic amines containing substituents on the ring, which are core structures of
many bioactive molecules. However, it is much more challenging to perform this strategy
on remote C–H bonds compared to the α-C–H bonds of cyclic amines. This graphical review
aims to provide a concise overview on transition-metal-catalyzed methods for the remote
C–H bond functionalization of cyclic amines. Examples are categorized and demonstrated
according to mechanistic pathways that initiate the reactions of cyclic amine substrates.
Where relevant, selected substrate scope and detailed reaction mechanisms are given.
Key words
C–H bond functionalization - remote - cyclic amines - transition metals - catalysis
- synthesis
