Association Of Blood Lipocalin-2 Levels with Gestational Diabetes
                    Mellitus: A Systematic Review and Meta-Analysis

Jing Zhu; Shuai Jiang; Xiaohong Jiang; Kaiming Luo; Xiaolin Huang; Fei Hua

doi:10.1055/a-1909-1922

Hormone and Metabolic Research, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Horm Metab Res 2022; 54(10): 677-685
DOI: 10.1055/a-1909-1922

Original Article: Endocrine Care

Association Of Blood Lipocalin-2 Levels with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Jing Zhu‡

¹Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China

,

Shuai Jiang‡

²Department of Emergency Medicine, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, China

³Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, Hangzhou, China

,

Xiaohong Jiang

¹Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China

,

Kaiming Luo

¹Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China

,

Xiaolin Huang

¹Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China

,

Fei Hua

¹Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China

› Institutsangaben

Abstract

Lipocalin-2 (LCN2) is becoming recognized as a pleiotropic mediator of metabolic disorders. However, the relationship between LCN2 and gestational diabetes mellitus (GDM) is not well understood. We performed a systematic review and meta-analysis to explore it. A systematic search of Cochrane Library, PubMed, Embase, Scopus, Web of Science, Chinese National Knowledge Infrastructure, and Wan-fang Database was done for relevant articles published up to September 29, 2021. Standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated to explore the association of LCN2 levels with GDM using Revman 5.3 and Stata 15.1. Fifteen case-control studies were included in this meta-analysis. The patients with GDM had significantly higher levels of blood LCN2 than parturients with normal glucose tolerance (SMD=3.41, 95% CI=2.24 to 4.58). Meta-regression and subgroup analysis were conducted to investigate the source of heterogeneity. Likely sources of heterogeneity were age and testing methods. This study found that GDM showed higher blood LCN2 levels than controls. However, caution is warranted on the interpretation of these findings. Standardized LCN2 measurement methods and longitudinal studies are required to disentangle and better understand the relationships observed.

Key words

lipocalin-2 - gestational diabetes mellitus - meta-analysis - insulin resistance - adipokines

Volltext

Referenzen

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