Open Access
CC BY-NC-ND 4.0 · Horm Metab Res 2022; 54(10): 677-685
DOI: 10.1055/a-1909-1922
Original Article: Endocrine Care

Association Of Blood Lipocalin-2 Levels with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Jing Zhu
1   Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China
,
Shuai Jiang
2   Department of Emergency Medicine, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, China
3   Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, Hangzhou, China
,
Xiaohong Jiang
1   Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China
,
Kaiming Luo
1   Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China
,
Xiaolin Huang
1   Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China
,
Fei Hua
1   Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China
› Author Affiliations

Funding This study was funded by Changzhou Health Commission Young Talents Project (QN202018), Natural Science Foundation of China (81900768), and General Project of Maternal and Child Health Research Project of Jiangsu Province (F201803).
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Abstract

Lipocalin-2 (LCN2) is becoming recognized as a pleiotropic mediator of metabolic disorders. However, the relationship between LCN2 and gestational diabetes mellitus (GDM) is not well understood. We performed a systematic review and meta-analysis to explore it. A systematic search of Cochrane Library, PubMed, Embase, Scopus, Web of Science, Chinese National Knowledge Infrastructure, and Wan-fang Database was done for relevant articles published up to September 29, 2021. Standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated to explore the association of LCN2 levels with GDM using Revman 5.3 and Stata 15.1. Fifteen case-control studies were included in this meta-analysis. The patients with GDM had significantly higher levels of blood LCN2 than parturients with normal glucose tolerance (SMD=3.41, 95% CI=2.24 to 4.58). Meta-regression and subgroup analysis were conducted to investigate the source of heterogeneity. Likely sources of heterogeneity were age and testing methods. This study found that GDM showed higher blood LCN2 levels than controls. However, caution is warranted on the interpretation of these findings. Standardized LCN2 measurement methods and longitudinal studies are required to disentangle and better understand the relationships observed.



Publication History

Received: 26 January 2022

Accepted after revision: 18 July 2022

Article published online:
07 October 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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