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DOI: 10.1055/a-1903-1752
Advanced Glycation End Products: Do They Impair Bone Health in Diabetes?
Abstract
In diabetes mellitus (DM), there is increased formation and accumulation of advanced glycation end products (AGEs), which represent a heterogeneous class of molecules produced by non-enzymatic glycation of various molecules during long-term hyperglycaemia. Several studies have examined the role of AGEs in DM complications. Accumulating evidence suggests that AGEs affect bone metabolism. New knowledge indicates that they may play a role in bone disease among DM subjects. More data are now needed to clarify their role and to explore new AGEs-based therapeutic options for optimal bone health in DM.
Publication History
Received: 11 June 2022
Received: 29 June 2022
Accepted: 07 July 2022
Article published online:
17 August 2022
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