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DOI: 10.1055/a-1903-1752
Advanced Glycation End Products: Do They Impair Bone Health in Diabetes?
Abstract
In diabetes mellitus (DM), there is increased formation and accumulation of advanced glycation end products (AGEs), which represent a heterogeneous class of molecules produced by non-enzymatic glycation of various molecules during long-term hyperglycaemia. Several studies have examined the role of AGEs in DM complications. Accumulating evidence suggests that AGEs affect bone metabolism. New knowledge indicates that they may play a role in bone disease among DM subjects. More data are now needed to clarify their role and to explore new AGEs-based therapeutic options for optimal bone health in DM.
Publikationsverlauf
Eingereicht: 11. Juni 2022
Eingereicht: 29. Juni 2022
Angenommen: 07. Juli 2022
Artikel online veröffentlicht:
17. August 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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