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CC BY 4.0 · TH Open 2022; 06(03): e267-e275
DOI: 10.1055/a-1897-7061
Original Article

Saddle Pulmonary Embolism in Patients with Cancer in the Era of Incidental Events: Clinical Findings and Outcomes in a Single Centre Cohort

Mario Aramberri 
1   Department of Internal Medicine, Hospital de Galdakao-Usansolo, Galdakao, Spain
,
Mariana Benegas
2   Department of Radiology, Hospital Clinic de Barcelona, Barcelona, Spain
,
Marcelo Sanchez
2   Department of Radiology, Hospital Clinic de Barcelona, Barcelona, Spain
,
Diego Muñoz-Guglielmetti
3   Department of Radiation Oncology, Barcelona, Spain
,
Carles Zamora
4   Department of Medical Oncology, Hospital Clinic de Barcelona, Barcelona, Spain
,
Adrián García-Villa
5   Department of Internal Medicine, Hospital Nuestra Señora del Prado, Talavera de la Reina, Spain
,
Carmen Diaz-Pedroche
6   Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain
,
Carme Font
4   Department of Medical Oncology, Hospital Clinic de Barcelona, Barcelona, Spain
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Abstract

Background There is scarce information regarding the prevalence and clinical impact of saddle pulmonary embolism (PE) in patients with cancer.

Objectives This study aimed to assess the prevalence, clinical findings, and short-term outcomes of patients with cancer-related saddle PE including acute symptomatic and unsuspected events.

Patients/Methods Consecutive patients with cancer-related PE (March 1, 2006–October 31, 2014) were retrospectively reviewed by a chest radiologist to assess PE burden and signs of right ventricular (RV) overload. The clinical outcomes within 30 days were evaluated according to saddle versus nonsaddle PE.

Results Thirty-six (12%) out of 289 patients with newly diagnosed cancer-related PE presented with saddle PE. Saddle PE was found in 21 cases (58%) with acute symptomatic PE and the remaining 15 cases (42%) were found as unsuspected findings. Patients with saddle PE had more frequently experienced a previous thrombotic event (31 vs. 13%; p = 0.008), and it occurred more frequently as an acute symptomatic event (58 vs. 39%; p = 0.025) compared with those with nonsaddle PE. Signs of RV overload including RV/left ventricle ratio ≥1 (22 vs. 4%; p < 0.001) and interventricular septum displacement (53 vs. 20%; p < 0.001) were also more common in patients with saddle PE compared with nonsaddle PE. Overall, PE-related mortality, venous thromboembolism recurrence, and major bleeding within 30 days were found to be similar according to saddle versus nonsaddle PE.

Conclusion Saddle PE is not uncommon in patients with cancer-related PE including in those with unsuspected PE. Similar 30-day outcomes were found according to saddle versus nonsaddle PE in our cohort.

Keywords

cancer - incidental findings - pulmonary embolism - thrombosis - venous thromboembolism

Note

This work has been partially reported at the following medical meetings: ISTH Virtual Congress 2020 (July 12–14, 2020), 10th ICTHIC VIRTUAL EDITION (April 22–24, 2021).




Publikationsverlauf

Eingereicht: 23. Mai 2022

Angenommen: 04. Juli 2022

Accepted Manuscript online:
12. Juli 2022

Artikel online veröffentlicht:
14. Dezember 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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