One-Pot Synthesis of 2-Arylquinolines via in situ Acid Catalysis

Abstract

A simple, efficient, and practical protocol is reported, allowing quick access to diverse 2-arylquinolines from 2-vinylanilines and benzyl halides. This reaction is additive and metal catalyst-free with only solvent needed. A preliminary mechanistic investigation discloses the driving force comes from the in situ released HBr, which catalyzes the subsequent cyclization. The present synthetic route featured high functional group tolerance and simple post-processing. A variety of 2-arylquinolines were obtained up to 96% yield.

Key words

metal-catalyst free - additive free - 2-arylquinolines - in situ acid - 2-vinylanilines

Publication History

Received: 24 May 2022

Accepted after revision: 01 July 2022

Accepted Manuscript online:
01 July 2022

Article published online:
08 August 2022

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