Updated S2k Clinical Practice Guideline on Non-alcoholic Fatty Liver Disease (NAFLD) issued by the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) – April 2022 – AWMF Registration No.: 021–025

List of Abbreviations

AASLD: American Association for the Study of Liver Diseases

AFP: Alpha-Fetoprotein

AHA: American Heart Association

AI: Artificial Intelligence

ALD: Alcohol-related Liver Disease

ALT: Alanineaminotransferase

API: Active pharmaceutical ingredient

APASL: Asian Pacific Association for the Study of the Liver

APRI: AST/platelet ratio

ASH: Alcoholic Steatohepatitis

AST: Aspartate aminotransferase

ATI: Attenuation Imaging

AUC: Area under the curve

AUROC: Area under the Receiver Operating Characteristic (ROC) Curve

BMI: Body-Mass-Index

CAP: Controlled Attenuation Parameter

CDT: Carbohydrate-Deficient Transferrin

CHE: Cholinesterase

CIL: Cilofexor

CMV: Cytomegalovirus

CT: Computed Tomography

CVC: Cenicriviroc

DECT: Dual-Energy CT

DM: Duodenal Mucosa

DPP4: Dipeptidyl Peptidase 4

%EWL: Percentage Excess Weight Loss

EASL: European Association for the Study of the Liver

EBV: Epstein-Barr Virus

ELF: Enhanced Liver Fibrosis

ELIVATE: Study of Efficacy, Safety and Tolerability of the Combination of Tropifexor & Licogliflozin and Each Monotherapy, Compared with Placebo in Adult Patients with NASH and Liver Fibrosis.

EPA: Ethyl Eicosapentaenic Acid

ERCP: Endoscopic Retrograde Cholangiopancreatography

ESG: Endoscopic sleeve gastroplasty

EtG: Ethylglucuronid

F1–F4: Stages of Liver Fibrosis 1–4

FASCINATE: Study of TVB-2640 in Subjects with Nonalcoholic Steatohepatitis (NASH)

FASN: Fatty Acid Synthase

FF: Fat Fraction

FGF: Fibroblast Growth Factor

FIR: Firsocostat

FLI: Fatty Liver Index

FLINT: The Farnesoid X Receptor (FXR) Ligand Obeticholic Acid in NASH Treatment Trial

FLIGHT-FXR: Study of Safety and Efficacy of Tropifexor (LJN452) in Patients with Non-alcoholic Steatohepatitis

FPG: Fasting Plasma Glucose

FXR: Farnesoid X Receptor

γ-GT: Gamma-Glutamyl Transferase

GI: Gastrointestinal

GLP-1: Glucagon-like Peptide 1

GOT: Glutamic-Oxaloacetic Transaminase

GPT: Glutamate-Pyruvate Transaminase

HA: Hyaluronic Acid

HAV: Hepatitis A Virus

HbA1c: Hemoglobin A1c

HBV: Hepatitis B Virus

HCC: Hepatocellular Carcinoma

HCV: Hepatitis C Virus

HDL: High-Density Lipoprotein

HDV: Hepatitis D Virus

HEV: Hepatitis E Virus

HIS: Hepatic Steatosis Index

Histo: Histology

HOMA: Homeostasis Model Assessment

HOMA-IR: Homeostasis Model Assessment – Insulin Resistance

HVPG: Hepatic-Venous Pressure Gradient

iCCa: Intrahepatic CholangiIocarcinoma

IDF: International Diabetes Federation

IQR: Interquartile Range

LDL: Low-Density Lipoprotein

LFS: Liver Fat Score

LSG: Laparoscopic Sleeve Gastrectomy

LT: Liver Transplantation

MAFLD: Metabolic Dysfunction-Associated Fatty Liver Disease

MDB: Mallory-Denk-Bodies

Met: Metformin

mo: Month

MRCP: Magnetic Resonance Cholangiopancreatography

MRE: Magnetic Resonance Elastography

MRI: Magnetic Resonance Imaging

MRS: Magnetic Resonance Spectroscopy

n3 PUFA: n-3 Polyunsaturated Fatty Acid

NAFLD: Non-Alcoholic Fatty Liver Disease

NAS: NAFLD Activity Score

NFS: NAFLD Fibrosis Score

NASH: Non-Alcoholic Steatohepatitis

NASH CRN: NASH Clinical Research Network

NHLBI: National Heart, Lung and Blood Institute

NPV: Negative Predictive Value​

OAGB: One-Anastomosis Gastric Bypass

OCA: Obeticholic Acid

OGTT: Oral Glucose Tolerance Test

OTC: Over the Counter

Pat.: Patient

PCOS: Polycystic ovary Syndrom

PDFF: Proton Density Fat-Fraction

PEth: Phosphatidylethanol

PIIINP: Procollagen III peptide

Pio: Pioglitazone

PMID: PubMed Identifier

p. o.: per os

PPAR: Peroxisome Proliferator-Activated Receptor

PPV: Positive Predictive Value

Prosp.: Prospective

PUFA: Polyunsaturated Fatty Acids

RYGB: Roux-Y Gastric Bypass

SCD-1: Stearoyl-CoA Desaturase 1

SG: Sleeve Gastrectomy

SGLT2: Sodium Dependent Glucose Co-transporter 2

SWE: Shear-Wave Elastography

%TWL: Percentage Total Weight Loss

T2DM: Type 2 Diabetes mellitus

TANDEM: Study of Safety, Tolerability, and Efficacy of a Combination Treatment of LJN452 and CVC in Adult Patients ith NASH and Liver Fibrosis

TBWL: Total Body Weight Loss

TE: Transient Elastography

TG: Triclyceride

THRß: Thyroid Hormone Receptor-Beta

TIMP-1: Tissue Inhibitor of Metalloproteinase-1

TZD: Thiazolidindione

UDCA: Ursodeoxycholic Acid

US: Ultrasound

VCTE: Vibration-Controlled Transient Elastography

Vit C: Vitamin C

Vit E: Vitamin E

Publikationsverlauf

Artikel online veröffentlicht:
13. September 2022

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