CC BY-NC-ND 4.0 · J Neurol Surg Rep 2022; 83(03): e83-e86
DOI: 10.1055/a-1871-3586
Skull Base Oncology Case Series

Sinonasal Undifferentiated Carcinoma with Failed Response to Induction Chemotherapy

Michael R. Papazian
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
Alex J. Gordon
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
Michael Chow
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
Donato Pacione
2   Department of Neurosurgery, NYU Langone Medical Center, New York, New York, United States
,
Seth Lieberman
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
› Author Affiliations

Abstract

Sinonasal undifferentiated carcinoma (SNUC) is a rapidly growing malignancy with a propensity for extensive local invasion. Multimodal therapy, including surgery, radiotherapy, and chemotherapy, is the standard approach to treatment, but the optimal sequence and combination of these modalities are uncertain. Induction chemotherapy is being increasingly utilized based on recent reports that show better outcomes for patients who respond to chemotherapy and the ability to determine further course of treatment. We present a unique case of a patient with locally advanced SNUC that did not respond to induction chemotherapy and a review of the available literature relating to the management of this rare malignancy.



Publication History

Received: 14 April 2022

Accepted: 02 June 2022

Accepted Manuscript online:
08 June 2022

Article published online:
10 July 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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