Am J Perinatol 2023; 40(01): 106-114
DOI: 10.1055/a-1850-3199
Original Article

Prevalence and Predictors of Pediatric COVID-19 Vaccine Acceptance

1   Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Aurora, Colorado, United States
Blair W. Weikel
1   Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Aurora, Colorado, United States
Claire Palmer
1   Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Aurora, Colorado, United States
Jessica R. Cataldi
2   Department of Pediatrics, Section of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, United States
3   Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, United States
Sarah Blackwell
4   Colorado Department of Public Health and Environment, Aurora, Colorado, United States
Sunah S. Hwang
1   Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Aurora, Colorado, United States
› Author Affiliations
Funding None.


Objective As pediatric COVID-19 vaccine eligibility expands, understanding predictors of vaccine intent is critical to effectively address parental concerns. Objectives included: (1) Evaluate maternal COVID-19 vaccine intent for child(ren) and associated predictors of stated intent; (2) Describe attitudes related to hypothetical vaccination policies; (3) Summarize themes associated with intention to vaccinate child(ren) for COVID-19.

Study Design Mothers enrolled in Heath eMoms, a longitudinal survey project, were recruited for this electronic COVID-19 survey. Chi-square analysis was used to compare proportions of respondent characteristics based on vaccination intent. Population survey logistic regression was used for multivariable modeling to assess the independent association between vaccine intent and demographics.

Results The response rate was 65.3% (n = 1884); 44.2% would choose vaccination, 20.3% would not choose vaccination, and 35.5% are unsure whether to have their child(ren) vaccinated for COVID-19. Black mothers (AOR 0.26, 95% CI 0.13, 0.54), respondents with less than high school education (AOR 0.26, 95% 0.12, 0.56) and those in rural areas (AOR 0.28, 95% CI 0.16, 0.48) were less likely to choose vaccination. Commonly cited reasons for vaccine hesitancy include the belief that the vaccine was not tested enough, is not safe, and there are concerns regarding its side effects.

Conclusion Over 50% of respondents do not intend or are unsure about their intent to vaccinate their child(ren) for COVID-19 with variability noted by demographics. Opportunities exist for perinatal and pediatric providers to educate pregnant people, parents, and caregivers with a focus on addressing concerns regarding vaccine safety and efficacy.

Key Points

  • COVID-19 vaccination rates remain suboptimal, especially in the pediatric population, with variation across states.

  • We found that the prevalence of vaccine acceptance for young children is low.

  • We highlight opportunities for providers to educate parents, focusing on addressing vaccine safety and efficacy.

Supplementary Material

Publication History

Received: 18 September 2021

Accepted: 06 May 2022

Accepted Manuscript online:
12 May 2022

Article published online:
07 June 2022

© 2022. Thieme. All rights reserved.

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