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J Neurol Surg B Skull Base 2023; 84(04): 329-335
DOI: 10.1055/a-1837-6825
Original Article

Primary Intracranial Adenoid Cystic Carcinoma: Report of Three Cases

Nikolaos Tsetsos
1   Department of Otorhinolaryngology—Head and Neck Surgery, “G. Papanikolaou” General Hospital, Thessaloniki, Greece
,
Alexandros Poutoglidis
1   Department of Otorhinolaryngology—Head and Neck Surgery, “G. Papanikolaou” General Hospital, Thessaloniki, Greece
,
Dimitrios Terzakis
2   Endoscopic Skull Base Centre Athens, Hygeia Hospital, Athens, Greece
,
Ioannis Epitropou
3   Department of Otorhinolaryngology, Metropolitan Hospital Athens, Athens, Attike, Greece
,
Amanda Oostra 
4   Department of Neurosurgery, Evangelismos University Hospital Athens, Athens, Greece
,
Christos Georgalas
2   Endoscopic Skull Base Centre Athens, Hygeia Hospital, Athens, Greece
5   Medical School, University of Nicosia, Nicosia, Cyprus
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Abstract

Objective Nasal cavity and paranasal sinuses host a variety of malignant tumors with adenoid cystic carcinoma (ACC) being the most frequent cancer of salivary gland origin. The histological origin of such tumors virtually precludes primarily intracranial localization. The aim of this study is to report cases of primarily intracranial ACC without evidence of other primary lesions at the end of an exhaustive diagnostic workup.

Methods An electronic medical record search complemented by manual searching was conducted to identify prospective and retrospective cases of intracranial ACCs treated in Endoscopic Skull Base Centre Athens at the Hygeia Hospital, Athens from 2010 until 2021 with a mean follow-up time of at least 3 years. Patients were included if after complete diagnostic workup there was no evidence of a nasal or paranasal sinus primary lesion and extension of the ACC. All patients were treated with a combination of endoscopic surgeries performed by the senior author followed by radiotherapy (RT) and/or chemotherapy.

Results Three unique illustrative cases (ACC involving the clivus, cavernous sinus and pterygopalatine fossa, one orbital ACC with pterygopalatine fossa and cavernous sinus involvement and one involving cavernous sinus, and Meckel's cave with extension to the foramen rotundum) were identified. All patients underwent subsequently proton or carbon-ion beam radiation therapy.

Conclusions Primary intracranial ACCs constitute an extremely rare clinical entity with atypical presentation, challenging diagnostic workup and management. The design of an international web-based database with a detailed report of these tumors would be extremely helpful.

Keywords

adenoid cystic carcinoma - endoscopic transnasal surgery - intracranial ACC - proton beam therapy


Publikationsverlauf

Eingereicht: 06. März 2022

Angenommen: 21. April 2022

Accepted Manuscript online:
27. April 2022

Artikel online veröffentlicht:
07. Juni 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Volpi L, Bignami M, Lepera D. et al. Endoscopic endonasal resection of adenoid cystic carcinoma of the sinonasal tract and skull base. Laryngoscope 2019; 129 (05) 1071-1077
    CrossrefPubMedSuche in Google Scholar
  • 2 Castelnuovo P, Turri-Zanoni M. Adenoid cystic carcinoma. Adv Otorhinolaryngol 2020; 84: 197-209
    PubMedSuche in Google Scholar
  • 3 Coca-Pelaz A, Rodrigo JP, Bradley PJ. et al. Adenoid cystic carcinoma of the head and neck—an update. Oral Oncol 2015; 51 (07) 652-661
    CrossrefPubMedSuche in Google Scholar
  • 4 Unsal AA, Chung SY, Zhou AH, Baredes S, Eloy JA. Sinonasal adenoid cystic carcinoma: a population-based analysis of 694 cases. Int Forum Allergy Rhinol 2017; 7 (03) 312-320
    CrossrefPubMedSuche in Google Scholar
  • 5 Lupinetti AD, Roberts DB, Williams MD. et al. Sinonasal adenoid cystic carcinoma: the M. D. Anderson Cancer Center experience. Cancer 2007; 110 (12) 2726-2731
    CrossrefPubMedSuche in Google Scholar
  • 6 Begum MS, Sarker UK, Islam MA, Sangma MA, Paul P, Rahman MA. Magnetic resonance imaging in evaluation of sinonasal masses with histopathological correlation. Mymensingh Med J 2018; 27 (01) 26-33
    PubMedSuche in Google Scholar
  • 7 Rawal RB, Farzal Z, Federspiel JJ, Sreenath SB, Thorp BD, Zanation AM. Endoscopic resection of sinonasal malignancy: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 2016; 155 (03) 376-386
    CrossrefPubMedSuche in Google Scholar
  • 8 Alleyne CH, Bakay RA, Costigan D, Thomas B, Joseph GJ. Intracranial adenoid cystic carcinoma: case report and review of the literature. Surg Neurol 1996; 45 (03) 265-271
    CrossrefPubMedSuche in Google Scholar
  • 9 Jayalakshmi S, Agarwal S, Nachiappan PL. et al. Intracranial adenoid cystic carcinoma—a case report. J Neurooncol 2000; 47 (01) 47-50
    CrossrefPubMedSuche in Google Scholar
  • 10 Kokemueller H, Eckardt A, Brachvogel P, Hausamen JE. Adenoid cystic carcinoma of the head and neck—a 20 years experience. Int J Oral Maxillofac Surg 2004; 33 (01) 25-31
    CrossrefPubMedSuche in Google Scholar
  • 11 Adachi K, Yoshida K, Ueda R, Kawase T. Adenoid cystic carcinoma of the cavernous region. Case report. Neurol Med Chir (Tokyo) 2006; 46 (07) 358-360
    CrossrefPubMedSuche in Google Scholar
  • 12 Donaldson C, Dawes B, Rathi V, Bulluss K. Adenoid cystic carcinoma presenting as abducens nerve palsy secondary to cavernous sinus lesion. Ann Neurosci 2017; 24 (03) 187-190
    CrossrefPubMedSuche in Google Scholar
  • 13 Abdul-Hussein A, Morris PA, Markova T. An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study. BMC Cancer 2007; 7: 157
    CrossrefPubMedSuche in Google Scholar
  • 14 Fortuna A, Gambacorta D. Cylindroma in the region of the Gasserian ganglion. Case report. J Neurosurg 1971; 34 (03) 427-431
    CrossrefPubMedSuche in Google Scholar
  • 15 McLellan DR, Adams JH. Adenoid cystic carcinoma presenting as intracranial tumour. Neuropathol Appl Neurobiol 1985; 11 (04) 309-315
    CrossrefPubMedSuche in Google Scholar
  • 16 Massey EW, Brannon WL, Friedman AJ, Pleet AB. Cylindroma (adenoid cystic carcinoma) causing unilateral cranial neuropathy. South Med J 1979; 72 (08) 1003-1005
    CrossrefPubMedSuche in Google Scholar
  • 17 Hara H, Tanaka Y, Tsuji T, Momose G, Kobayashi S. Intracranial adenoid cystic carcinoma. A case report. Acta Neurochir (Wien) 1983; 69 (3-4): 291-295
    CrossrefPubMedSuche in Google Scholar
  • 18 Morioka T, Matsushima T, Ikezaki K. et al. Intracranial adenoid cystic carcinoma mimicking meningioma: report of two cases. Neuroradiology 1993; 35 (06) 462-465
    CrossrefPubMedSuche in Google Scholar
  • 19 Piepmeier JM, Virapongse C, Kier EL, Kim J, Greenberg A. Intracranial adenocystic carcinoma presenting as a primary brain tumor. Neurosurgery 1983; 12 (03) 348-352
    CrossrefPubMedSuche in Google Scholar
  • 20 Swash M. Invasion of cranial nerves by salivary cylindroma: four cases treated by radiotherapy. J Neurol Neurosurg Psychiatry 1971; 34 (04) 475-480
    CrossrefPubMedSuche in Google Scholar
  • 21 Venkitaraman R, Madhavan J, Ramachandran K, Abraham E, Rajan B. Primary adenoid cystic carcinoma presenting as an orbital apex tumor. Neuroophthalmology 2008; 32 (01) 27-32
    CrossrefPubMedSuche in Google Scholar
  • 22 Hayashi Y, Iwato M, Kita D, Miyashita K, Yoshizaki T, Hamada J. Adenoid cystic carcinoma in the cavernous sinus diagnosed with the endoscopic endonasal approach. Turk Neurosurg 2014; 24 (05) 814-818
    PubMedSuche in Google Scholar
  • 23 Castelnuovo P, Turri-Zanoni M, Battaglia P, Antognoni P, Bossi P, Locatelli D. Sinonasal malignancies of anterior skull base: histology-driven treatment strategies. Otolaryngol Clin North Am 2016; 49 (01) 183-200
    CrossrefPubMedSuche in Google Scholar
  • 24 Alfieri A, Jho HD. Endoscopic endonasal approaches to the cavernous sinus: surgical approaches. Neurosurgery 2001; 49 (02) 354-360 , discussion 360–362
    PubMedSuche in Google Scholar
  • 25 Liu HS, Di X. Endoscopic endonasal surgery for biopsy of cavernous sinus lesions. Minim Invasive Neurosurg 2009; 52 (02) 69-73
    Thieme ConnectPubMedSuche in Google Scholar
  • 26 Miglianico L, Eschwege F, Marandas P, Wibault P. Cervico-facial adenoid cystic carcinoma: study of 102 cases. Influence of radiation therapy. Int J Radiat Oncol Biol Phys 1987; 13 (05) 673-678
    CrossrefPubMedSuche in Google Scholar
  • 27 Gentile MS, Yip D, Liebsch NJ, Adams JA, Busse PM, Chan AW. Definitive proton beam therapy for adenoid cystic carcinoma of the nasopharynx involving the base of skull. Oral Oncol 2017; 65: 38-44
    CrossrefPubMedSuche in Google Scholar
  • 28 Meldrum ML, Tse DT, Benedetto P. Neoadjuvant intracarotid chemotherapy for treatment of advanced adenocystic carcinoma of the lacrimal gland. Arch Ophthalmol 1998; 116 (03) 315-321
    CrossrefPubMedSuche in Google Scholar
  • 29 Tsuyuguchi N, Ohata K, Goto T, Haque M, Hara M. Intracranial adenoid cystic carcinoma of suprasellar region. Acta Neurochir (Wien) 2001; 143 (07) 729-732
    CrossrefPubMedSuche in Google Scholar
  • 30 Pitman KT, Prokopakis EP, Aydogan B. et al. The role of skull base surgery for the treatment of adenoid cystic carcinoma of the sinonasal tract. Head Neck 1999; 21 (05) 402-407
    CrossrefPubMedSuche in Google Scholar
  • 31 Terasaki M, Tokutomi T, Maruiwa H, Sugita Y, Harada H, Shigemori M. High-grade adenoid cystic carcinoma originating from the lacrimal gland. Brain Tumor Pathol 2000; 17 (03) 159-163
    CrossrefPubMedSuche in Google Scholar
  • 32 Pommier P, Liebsch NJ, Deschler DG. et al. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 2006; 132 (11) 1242-1249
    CrossrefPubMedSuche in Google Scholar
  • 33 Gamel JW, Font RL. Adenoid cystic carcinoma of the lacrimal gland: the clinical significance of a basaloid histologic pattern. Hum Pathol 1982; 13 (03) 219-225
    CrossrefPubMedSuche in Google Scholar