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CC BY-NC-ND 4.0 · SynOpen 2022; 06(02): 110-131
DOI: 10.1055/a-1826-2852
DOI: 10.1055/a-1826-2852
Graphical Review
Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds
The Dr. Ralph and Marian Falk Medical Research Trust (Transformational Award) and the National Institutes of Health (NIH) (R21 AI148986) provided financial support.
Abstract
The synthesis of aromatic heterocycles has attracted substantial attention due to the abundance of these heterocycles in drug molecules, natural products, and other compounds of biological interest. Accordingly, there is a demand for straightforward synthetic protocols toward such compounds using readily available starting materials. In the past decade, there have been substantial developments in heterocycle synthesis, especially in metal-catalyzed and iodine-assisted approaches. This graphical review focuses on notable reactions from the past decade using aryl and heteroaryl methyl ketones as starting materials, including representative reaction mechanisms.
Key words
aromatic heterocycles - iodine - ketones - metal-free - fused bicycles - fused tricycles - fused polyheterocyclesPublication History
Received: 12 January 2022
Accepted after revision: 06 April 2022
Accepted Manuscript online:
14 April 2022
Article published online:
08 June 2022
© 2022. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Georg Thieme Verlag KG
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