Impact of Preoperative Cervical Length on Pregnancy Outcome in
                    Twin-Twin Transfusion Syndrome

Javier U. Ortiz; Elisenda Eixarch; Talita Micheletti; Silvia M. Lobmaier; Mar Bennasar; Josep M. Martinez; Eduard Gratacós

doi:10.1055/a-1812-5608

Zeitschrift für Geburtshilfe und Neonatologie, Table of Contents

Z Geburtshilfe Neonatol 2022; 226(04): 245-250
DOI: 10.1055/a-1812-5608

Original Article

Impact of Preoperative Cervical Length on Pregnancy Outcome in Twin-Twin Transfusion Syndrome

Javier U. Ortiz

¹University of Barcelona, Institut d’Investigations Biomèdiques August Pi i Sunyer (IDIBAPS), and Centre for Biomedical Research on Rare Diseases (CIBER-ER), BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Barcelona, Spain

²University Hospital rechts der Isar, Technical University of Munich, Division of Obstetrics and Perinatal Medicine, Munich, Germany

,

Elisenda Eixarch

¹University of Barcelona, Institut d’Investigations Biomèdiques August Pi i Sunyer (IDIBAPS), and Centre for Biomedical Research on Rare Diseases (CIBER-ER), BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Barcelona, Spain

,

Talita Micheletti

¹University of Barcelona, Institut d’Investigations Biomèdiques August Pi i Sunyer (IDIBAPS), and Centre for Biomedical Research on Rare Diseases (CIBER-ER), BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Barcelona, Spain

,

Silvia M. Lobmaier

¹University of Barcelona, Institut d’Investigations Biomèdiques August Pi i Sunyer (IDIBAPS), and Centre for Biomedical Research on Rare Diseases (CIBER-ER), BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Barcelona, Spain

²University Hospital rechts der Isar, Technical University of Munich, Division of Obstetrics and Perinatal Medicine, Munich, Germany

,

Mar Bennasar

¹University of Barcelona, Institut d’Investigations Biomèdiques August Pi i Sunyer (IDIBAPS), and Centre for Biomedical Research on Rare Diseases (CIBER-ER), BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Barcelona, Spain

,

Josep M. Martinez

¹University of Barcelona, Institut d’Investigations Biomèdiques August Pi i Sunyer (IDIBAPS), and Centre for Biomedical Research on Rare Diseases (CIBER-ER), BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Barcelona, Spain

,

Eduard Gratacós

¹University of Barcelona, Institut d’Investigations Biomèdiques August Pi i Sunyer (IDIBAPS), and Centre for Biomedical Research on Rare Diseases (CIBER-ER), BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Barcelona, Spain

› Author Affiliations

Abstract

Objective To evaluate the impact of preoperative cervical length on pregnancy outcome in monochorionic diamniotic twin pregnancies complicated by twin-twin transfusion syndrome that underwent laser surgery or cord occlusion.

Materials and Methods Retrospective study of 330 patients stratified by preoperative cervical length (≥25 mm, 16–24 mm,≤15 mm). Maternal characteristics, operative data, and pregnancy outcomes were compared between the cervical length groups as well as between the subgroups of patients with a cervical length≤15 mm according to management (expectant vs. cerclage).

Results A preoperative cervical length≥25 mm was observed in 82% (n=271) of cases, 16–24 mm in 9% (n=29), and≤15 mm in 9% (n=30). Patients with a preoperative cervical length≤15 mm showed shorter median procedure-to-delivery interval (5.5 weeks vs. 11.6 (16–24 mm) vs. 13.0 (≥25 mm); p<0.001); lower median gestational age at delivery (29.5 weeks vs. 34.3 (16–24 mm) vs. 33.4 (≥25 mm); p<0.001); higher rate of preterm delivery<32 weeks (78 vs. 20% (16–24 mm) vs. 31% (≥25 mm); p<0.001); and lower neonatal survival rate of at least one twin (70 vs. 88% (16–24 mm) vs. 93% (≥25 mm); p<0.001). Outcome of patients with a preoperative cervical length≤15 mm was similar regardless of management.

Conclusion Monochorionic diamniotic twin pregnancies complicated by twin-twin transfusion syndrome with a preoperative cervical length≤15 mm showed a higher rate of preterm delivery<32 weeks and lower neonatal survival. The role of a cervical cerclage remains unclear.

Key words

Monochorionic twin pregnancy - Twin-twin transfusion syndrome - Short cervix

Full Text

References

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