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DOI: 10.1055/a-1810-6646
Cardiovascular Regulation During Acute Gravitational Changes with Exhaling on Exertion
Authors
Funding This research was supported by the founding of the German Aerospace Center (DLR e.V.;FKZ:50WB1426).
Abstract
During gravitational changes or changes in the direction of action in relation to the body, fluid displacements can be observed. In special cases different breathing maneuvers (e. g., exhaling on exertion; Ex-Ex) are used to counteract acute fluid shifts. Both factors have a significant impact on cardiovascular regulation. Eight healthy male subjects were tested on a tilt seat, long arm human centrifuge, and parabolic flight. The work aims to investigate the effect of exhaling on exertion on the cardiovascular regulation during acute gravitational changes compared to normal breathing. Possible interactions and differences between conditions (Ex-Ex, normal breathing) for the parameters V’O 2 , V’ E , HR, and SV were analysed over a 40 s period by a three-way ANOVA. Significant (p≤0.05) effects for all main factors and interactions between condition and time as well as maneuver and time were found for all variables. The exhaling on exertion maneuver had a significant influence on the cardiovascular response during acute gravitational and positional changes. For example, the significant increase of V’O2 at the end of the exhalation on exertion maneuver indicates an increased lung circulation as a result of the maneuver.
# Andreas Werner and Uwe Hoffmann are sharing the last authorship.
Publication History
Received: 02 August 2021
Accepted: 14 March 2022
Article published online:
03 June 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Convertino V, Hoffler GW. Cardiovascular physiology. Effects of microgravity. J Fla Med Assoc 1992; 79: 517-524
- 2 Linnarsson D, Hughson RL, Fraser KS. et al. Effects of an artificial gravity countermeasure on orthostatic tolerance, blood volumes and aerobic power after short-term bed rest (BR-AG1). J Appl Physiol (1985) 2015; 118: 29-35
- 3 Hoffmann U, Koschate J, Appell Coriolano HJ. et al. Adaptation of systemic and pulmonary circulation to acute changes in gravity and body position. Aerosp Med Hum Perform 2019; 90: 688-695
- 4 Blomqvist CG, Stone HL. Cardiovascular adjustments to gravitational stress. In: Terjung R (Ed). Comprehensive Physiology, Supplement 8: Handbook of Physiology, The Cardiovascular System, Peripheral Circulation and Organ Blood Flow. Wiley Online Library. 2011: 1025-1063
- 5 Fritsch-Yelle JM, Charles JB, Jones MM. et al. Microgravity decreases heart rate and arterial pressure in humans. J Appl Physiol (1985) 1996; 80: 910-914
- 6 Gunga H-C. Cardiovascular System, Red Blood Cells, and Oxygen Transport in Microgravity. Cham: Springer International Publishing; 2016
- 7 Kramer BK, Mang JF, Schubert R. The effect of microgravity on central aortic blood pressure. Am J Hypertens 2018; 31: 1180-1182
- 8 Pump B, Videbaek R, Gabrielsen A. et al. Arterial pressure in humans during weightlessness induced by parabolic flights. J Appl Physiol (1985) 1999; 87: 928-932
- 9 Seibert FS, Bernhard F, Stervbo U. et al. The effect of microgravity on central aortic blood pressure. Am J Hypertens 2018; 31: 1183-1189
- 10 Junqueira LF. Teaching cardiac autonomic function dynamics employing the Valsalva (Valsalva-Weber) maneuver. Adv Physiol Educ 2008; 32: 100-106
- 11 Looga R. The Valsalva manoeuvre – cardiovascular effects and performance technique: a critical review. Respir Physiol Neurobiol 2005; 147: 39-49
- 12 Ghazal SN. Valsalva maneuver in echocardiography. J Echocardiogr 2017; 15: 1-5
- 13 Pstras L, Thomaseth K, Waniewski J. et al. The Valsalva manoeuvre: physiology and clinical examples. Acta Physiol (Oxf) 2016; 217: 103-119
- 14 Shubrooks SJ, SD Leverett. Effect of the Valsalva maneuver on tolerance to+G z acceleration. J Appl Physiol 1973; 34: 460-466
- 15 Seedhouse E, Pulling G. Human Responses to High and Low Gravity. New York, NY: Springer; 2013
- 16 Banks RD, Brinkley JW, Allnutt R. et al. Human response to acceleration.. In: Fundamentals of Aerospace Medicine Fourth edition Philadelphia, USA: Lippincott Williams & Wilkins, a Wolters Kluwer business; 2011: 83-109
- 17 Crystal GJ, Salem MR. The Bainbridge and the “reverse” Bainbridge reflexes: history, physiology, and clinical relevance. Anesth Analg 2012; 114: 520-532
- 18 Hargens AR, Watenpaugh DE. Cardiovascular adaptation to spaceflight. Med Sci Sports Exerc 1996; 28: 977-982
- 19 Schlegel TT, Benavides EW, Barker DC. et al. Cardiovascular and Valsalva responses during parabolic flight. J Appl Physiol (1985) 1998; 85: 1957-1965
- 20 Peterson K, Ozawa ET, Pantalos GM. et al. Numerical simulation of the influence of gravity and posture on cardiac performance. Ann Biomed Eng 2002; 30: 247-259
- 21 Toska K, Walløe L. Dynamic time course of hemodynamic responses after passive head-up tilt and tilt back to supine position. J Appl Physiol (1985) 2002; 92: 1671-1676
- 22 Galiè N, Humbert M, Vachiery JL. et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J 2016; 37: 67-119
- 23 Jain P, Rao S, Macdonald P. et al. Diagnostic performance of pulmonary capacitance at rest and during exercise in idiopathic pulmonary arterial hypertension. Heart Lung Circ 2019; 28: 289-294
- 24 Thenappan T, Ormiston ML, Ryan JJ. et al. Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ 2018; 360: j5492
- 25 Pletser V, Rouquette S, Friedrich U. et al. The first European parabolic flight campaign with the Airbus A310 ZERO-G Microgravity Sci Technol. 2016; 28: 587-601
- 26 Lamb LE, Roman J. The head-down tilt and adaptability for aerospace flight. Aerosp Med 1961; 32: 473-486
- 27 Beaver WL, Lamarra N, Wasserman K. Breath-by-breath measurement of true alveolar gas exchange. J Appl Physiol Respir Environ Exerc Physiol 1981; 51: 1662-1675
- 28 Novak L, Penaz J, Kotovskaya AR. et al. Perspectives for the application of the Penaz’s method for a non-invasive continuous blood pressure measurement in space medicine. Physiologist 1991; 34: S230-S231
- 29 Wesseling KH. A century of noninvasive arterial pressure measurement: from Marey to Peñáz and Finapres. 1995; 36: 50 -66. Homeost Health Dis 1995; 36: 50-66
- 30 Harms MP, Wesseling KH, Pott F. et al. Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress. Clin Sci (Lond) 1999; 97: 291-301
- 31 Jellema WT, Imholz BP, Oosting H. et al. Estimation of beat-to-beat changes in stroke volume from arterial pressure: a comparison of two pressure wave analysis techniques during head-up tilt testing in young, healthy men. Clin Auton Res 1999; 9: 185-192
- 32 Cohen J. Statistical Ppower Analysis for the Behavioral Sciences. Hillsdale, N.J.: L. Erlbaum Associates; 1988
- 33 Srivastav S, Zeltser R. Valsalva Maneuver. In: StatPearls. Treasure Island (FL): StatPearls Publishing LLC.; 2018
- 34 Rothe CF. Reflex control of veins and vascular capacitance. Physiol Rev 1983; 63: 1281-1342
- 35 Hakumaki MO. Seventy years of the Bainbridge reflex. Acta Physiol Scand 1987; 130: 177-185
- 36 Heesch CM. Reflexes that control cardiovascular function. Am J Physiol 1999; 277: S234-S243
- 37 Looga R. Reflex cardiovascular responses to lung inflation: a review. Respir Physiol 1997; 109: 95-106
- 38 Rohdin M, Linnarsson D. Differential changes of lung diffusing capacity and tissue volume in hypergravity. J Appl Physiol (1985) 2002; 93: 931-935
- 39 Qureshi MU, Vaughan GD, Sainsbury C. et al. Numerical simulation of blood flow and pressure drop in the pulmonary arterial and venous circulation. Biomech Model Mechanobiol 2014; 13: 1137-1154
- 40 Suresh K, Shimoda LA. Lung circulation. Compr Physiol 2016; 6: 897-943
- 41 Groepenhoff H, Westerhof N, Jacobs W. et al. Exercise stroke volume and heart rate response differ in right and left heart failure. Eur J Heart Fail 2010; 12: 716-720
- 42 Newman APDG. High G Flight: Physiological Effects and Countermeasures. Ashgate Publishing Limited. 2015
- 43 Goswami N, Blaber AP, Hinghofer-Szalkay H. et al. Lower body negative pressure: Physiological effects, applications, and implementation. Physiol Rev 2019; 99: 807-851
- 44 Brosius F. SPSS: Umfassendes Handbuch zu Statistik und Datenanalyse. 8. Auflage. Aufl. Frechen: MITP Verlags GmbH & Co KG; 2018
- 45 Wilcox RR. Introduction to Robust Estimation and Hypothesis Testing. 3. Auflage. Aufl. Amsterdam: Elsevier/Academic Press; 2012