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Hamostaseologie 2022; 42(06): 409-419
DOI: 10.1055/a-1755-8676
Review Article

Assessment and Monitoring of Coagulation in Patients with COVID-19: A Review of Current Literature

Authors

  • Günalp Uzun

    1   Center for Clinical Transfusion Medicine, University Hospital of Tuebingen, Tuebingen, Germany

  • Karina Althaus

    1   Center for Clinical Transfusion Medicine, University Hospital of Tuebingen, Tuebingen, Germany
    2   Medical Faculty of Tuebingen, Institute for Clinical and Experimental Transfusion Medicine, Tuebingen, Germany

  • Stefanie Hammer

    1   Center for Clinical Transfusion Medicine, University Hospital of Tuebingen, Tuebingen, Germany

  • Tamam Bakchoul

    1   Center for Clinical Transfusion Medicine, University Hospital of Tuebingen, Tuebingen, Germany
    2   Medical Faculty of Tuebingen, Institute for Clinical and Experimental Transfusion Medicine, Tuebingen, Germany

Funding This work was supported by grants from the German Research Foundation and from the Herzstiftung to T.B. (BA5158/4 and TSG-Study).
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Abstract

Coagulation abnormalities are common in patients with COVID-19 and associated with high morbidity and mortality. It became a daily challenge to navigate through these abnormal laboratory findings and deliver the best possible treatment to the patients. The unique character of COVID-19-induced coagulopathy necessitates not only a dynamic follow-up of the patients in terms of hemostatic findings but also the introduction of new diagnostic methods to determine the overall function of the coagulation system in real time. After the recognition of the high risk of thromboembolism in COVID-19, several professional societies published their recommendations regarding anticoagulation in patients with COVID-19. This review summarizes common hemostatic findings in COVID-19 patients and presents the societal recommendations regarding the use of coagulation laboratory findings in clinical decision-making. Although several studies have investigated coagulation parameters in patients with COVID-19, the methodological shortcomings of published studies as well as the differences in employed anticoagulation regimens that have changed over time, depending on national and international guidelines, limit the applicability of these findings in other clinical settings. Accordingly, evidence-based recommendations for diagnostics during acute COVID-19 infection are still lacking. Future studies should verify the role of coagulation parameters as well as viscoelastic methods in the management of patients with COVID-19.

Keywords

coagulopathy - D-dimer - thrombosis - fibrinolysis

Authors' Contributions

G.U., K.A., S.H., and T.B. searched the literature, reviewed the available articles, and wrote the manuscript. All authors read and approved the final manuscript.




Publikationsverlauf

Eingereicht: 16. Mai 2021

Angenommen: 28. Januar 2022

Artikel online veröffentlicht:
27. April 2022

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