Zeitschrift für Phytotherapie 2022; 43(01): 21-23
DOI: 10.1055/a-1746-1551
Peer Review

Zur antiviralen Wirkung von Zubereitungen aus dem Knoblauch

Studies on the Antiviral Effect of Preparations from Garlic
Julia Vlachojannis
1   Institut für Rechtsmedizin, Universität Freiburg
Sigrun Chrubasik-Hausmann
1   Institut für Rechtsmedizin, Universität Freiburg
› Author Affiliations


An der antiviralen Wirkung von Knoblauch mit seinen organischen Schwefelverbindungen und Lektinen muss nicht gezweifelt werden. Die viruzide Wirkung wurde experimentell für unbehüllte und behüllte, Pandemien auslösende Viren demonstriert. Am antiviralen Wirkungsmechanismus sind eine Interaktion mit den Rezeptoren der Zielzelle, eine Hemmung der Enzyme, die das Eindringen in die Zielzelle ermöglichen, eine Hemmung der Replikation und Ausscheidung der Virionen beteiligt. Sieben exploratorische Studien weisen auf eine potente antivirale Wirksamkeit. Konfirmatorische Studien müssen jetzt für jede Knoblauch-Zubereitung die optimale Dosis und die Wirkgröße zur Prävention und Therapie viraler Infektionen evaluieren.


The antiviral effect of garlic and its organosulfur and lectin compounds is beyond any doubt. In vitro experiments demonstrate the virucidal effect on viruses without envelopes or with envelopes. The latter are the ones causing pandemics. The antiviral mechanism of action include various targets, e. g. receptor interaction, inhibition of enzymes that enable penetration into cells, inhibition of replication and excretion of virions. Seven exploratory studies indicate a potent antiviral effectiveness in humans. Confirmatory studies must now evaluate the effect size for every garlic preparation after dose-finding studies have established the optimum daily dosage for the prevention and treatment of viral infections.

Publication History

Received: 13 January 2022

Accepted: 10 February 2022

Article published online:
15 March 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

  • Literatur

  • 1 Andrianova IV, Sobenin IA, Sereda EV. et al. Effect of long-acting garlic tablets “allicor” on the incidence of acute respiratory viral infections in children. Ter Arkh 2003; 75: 53-56
  • 2 ESCOP. Allii sativa bulbus. In: ESCOP Monographs. Stuttgart, New York: Thieme; 2003: 14-25
  • 3 Gołebiowska-Wawrzyniak M, Markiewicz K, Kozar A. et al. Immunological and clinical study on therapeutic efficacy of inosine pranobex. Pol Merkur Lekarski 2005; 19: 379-382
  • 4 Hiltunen R, Josling PD, James MH. Preventing airborne infection with an intranasal cellulose powder formulation (Nasaleze travel). Adv Ther 2007; 24: 1146-1153
  • 5 Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther 2001; 18: 189-193
  • 6 Kenawy S, Mohammed GF, Younes S, Elakhras AI. Evaluation of TNF-α serum level in patients with recalcitrant multiple common warts, treated by lipid garlic extract. Dermatol Ther 2014; 27: 272-277
  • 7 Lee MH, Kim YM, Kim SG. Efficacy and tolerability of diphenyldimethyl-dicarboxylate plus garlic oil in patients with chronic hepatitis. Int J Clin Pharmacol Ther 2012; 50: 778-786
  • 8 Mousavi ZB, Mehrabian A, Golfakhrabadi F, Namjoyan F. A clinical study of efficacy of garlic extract versus cryotherapy in the treatment of male genital wart. Dermatologica Sinica 2018; 36: 196-199
  • 9 Nantz MP, Rowe CA, Muller CE. et al. Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition intervention. Clin Nutr 2012; 31: 337-344
  • 10 Rawangkan A, Kengkla K, Kanchanasurakit S. et al. Anti-influenza with green tea catechins: a systematic review and meta-analysis. Molecules 2021; 26: 4014
  • 11 Rouf R, Uddin SJ, Sarker DK. et al. Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data. Trends Food Sci Technol 2020; 104: 219-234
  • 12 Umeda M, Tominaga T, Kozuma K. et al. Preventive effects of tea and tea catechins against influenza and acute upper respiratory tract infections: a systematic review and meta-analysis. Eur J Nutr 2021; 60: 4189-4202
  • 13 Vlachojannis J, Chrubasik-Hausmann S. Knoblauch zur Gesunderhaltung. Teil 1. Zubereitungen aus Knoblauch und ihre Inhaltsstoffe. Z Phytother 2018; 39: 63-65 DOI: 10.1055/a-0603-2566.
  • 14 Weber ND, Andersen DO, North JA. et al. In vitro virucidal effects of Allium sativum (garlic) extract and compounds. Planta Med 1992; 58: 417-423
  • 15 WHO Monographs on Selected Plants. 1999, Volume 1. http://apps.who.int/medicinedocs/en/d/Js2200e/4.html
  • 16 Yuan Y, Wang RT, Xia J, Cao HJ. Interventions for preventing influenza: An overview of Cochrane systematic reviews and a Bayesian network meta-analysis. J Integr Med 2021; 19: 503-514