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CC BY 4.0 · TH Open 2022; 06(02): e89-e95
DOI: 10.1055/a-1742-0465
Original Article

Public Awareness on Cancer-Associated Thrombosis among the Greek Population: First Findings from the ROADMAP-CAT Awareness Study

Kyriakos Souliotis 
1   Department of Social and Education Policy, University of Peloponnese, Corinth, Greece
2   Research Department, Health Policy Institute, Maroussi, Athens, Greece
,
Christina Golna
3   Policy Change Department, Innowth, Larnaca, Cyprus
,
Sofia Nikolaidi
2   Research Department, Health Policy Institute, Maroussi, Athens, Greece
,
Patrick V. Dreden
4   Sorbonne University, Institut National de la Santé et de la Recherche Médicale (INSERM), Unit 938, Research Group Cancer, Biology and Therapeutics, Centre de Recherche Saint-Antoine (CRSA), Institut Universitaire de Cancérologie, Paris, France
5   Department of Clinical Research, Diagnostica Stago, Gennevilliers, France
,
Georgia Vatheia
2   Research Department, Health Policy Institute, Maroussi, Athens, Greece
,
Grigoris T. Gerotziafas 
4   Sorbonne University, Institut National de la Santé et de la Recherche Médicale (INSERM), Unit 938, Research Group Cancer, Biology and Therapeutics, Centre de Recherche Saint-Antoine (CRSA), Institut Universitaire de Cancérologie, Paris, France
6   Thrombosis Center, Tenon-Saint Antoine, Hôpitaux Universitaires de l'Est Parisien, Assistance Publique Hôpitaux de Paris (APHP), France
› Institutsangaben Funding This work was supported by an unrestricted research grant from Leo Pharma Hellas.
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Abstract

Background Cancer-associated thrombosis (CAT) is the second cause of mortality after cancer itself. CAT is underestimated as a health challenge among oncologists, whereas the levels of awareness among patients and the public have not been systematically assessed and followed in the European Union countries.

Aim The Prospective Risk Assessment and Management of Patient with CAT (ROADMAP-CAT) Awareness study is an investigator-initiated, descriptive and nonexperimental study with a cross-sectional design and it explores CAT risk awareness among cancer patients and the general public in Greece to provide an impetus for health policy interventions and a benchmark against which impact of any future interventions may be assessed.

Methods A total of 1,003 participants aged above 18 years were contacted by phone after random selection from the national telephone catalogue. Participation was voluntary and completely anonymous, and a structured questionnaire was used to elicit responses. Data were analyzed using IBM SPSS version 25.

Results Among respondents, almost one-third (32.3%) reported CAT awareness, while only one in five (21.7%) were aware of the signs and symptoms of venous thromboembolism (VTE). Among patients with a personal history of cancer or of VTE, 47 and 58%, respectively, were aware of CAT risk. Of those aware of the association, 35.2% identified their treating physician as the main source of information. The level of awareness did not significantly differ by responders' demographics.

Conclusion The ROADMAP-CAT Awareness study revealed very low levels of awareness on CAT and VTE risk both among the general public and cancer patients in Greece. Awareness of the signs and symptoms of VTE was also particularly low. Treating physicians are not actively engaging in educating their patients about CAT. Public awareness of the increased risk of VTE among cancer patients is critical to prevent and diagnose the disease early. It is imperative that a structured campaign supports medical professionals to take the time to increase awareness and educate their patients on this matter if to improve morbidity and mortality of cancer patients.

Keywords

venous thromboembolism - deep vein thrombosis - pulmonary embolism - cancer - public awareness

Ethics

Participation in this study was on a voluntary basis. All respondents were informed of the voluntary nature of the survey. The study was approved by the local institutional ethics committee.




Publikationsverlauf

Eingereicht: 11. Juni 2021

Angenommen: 21. Oktober 2021

Accepted Manuscript online:
17. Januar 2022

Artikel online veröffentlicht:
27. April 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients. Cancer 2007; 110 (10) 2339-2346
    CrossrefPubMedGoogle Scholar
  • 2 Michael H, Kroll MH, Pemmaraju N, Oo TH, Afshar-Kharghan V, Kroll S. Mortality from cancer-associated venous thromboembolism. Blood 2014; 124: 4829
    CrossrefPubMedGoogle Scholar
  • 3 Wun T, White RH. Epidemiology of cancer-related venous thromboembolism. Best Pract Res Clin Haematol 2009; 22 (01) 9-23
    CrossrefPubMedGoogle Scholar
  • 4 Almohammed OA, Lai L, Khanfar NM, Bleidt B, Aljadhey H. Trends of cancer-associated venous thromboembolism (VTE) in the United States (2005-2014). Thromb Res 2019; 182: 110-115
    CrossrefPubMedGoogle Scholar
  • 5 Tran BH, Nguyen TJ, Hwang BH. et al. Risk factors associated with venous thromboembolism in 49,028 mastectomy patients. Breast 2013; 22 (04) 444-448
    CrossrefPubMedGoogle Scholar
  • 6 Moore RA, Adel N, Riedel E. et al. High incidence of thromboembolic events in patients treated with cisplatin-based chemotherapy: a large retrospective analysis. J Clin Oncol 2011; 29 (25) 3466-3473
    CrossrefPubMedGoogle Scholar
  • 7 Prandoni P, Lensing AW, Piccioli A. et al. Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood 2002; 100 (10) 3484-3488
    CrossrefPubMedGoogle Scholar
  • 8 Lyman GH, Khorana AA, Falanga A. Thrombosis and cancer: emerging data for the practicing oncologist. Am Soc Clin Oncol Educ Book 2013
    Google Scholar
  • 9 European Thrombosis & Haemostasis Alliance. European Thrombosis & Haemostasis Alliance consensus statement. Accessed February 1, 2022 at: http://etha.eu/wp-content/uploads/2018/03/European-Thrombosis-Consensus-Statement.pdf
    Google Scholar
  • 10 Scotte F, Martelli N, Vainchtock A, Borget I. The cost of thromboembolic events in hospitalized patients with breast or prostate cancer in France. Adv Ther 2015;32(2):138-147
  • 11 Kahn SR, Lim W, Dunn AS. et al. Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (2, suppl) e195S-e226S
    CrossrefPubMedGoogle Scholar
  • 12 Nicolaides AN, Fareed J, Kakkar AK. et al. Prevention and treatment of venous thromboembolism–International Consensus Statement. Int Angiol 2013; 32 (02) 111-260
    PubMedGoogle Scholar
  • 13 Debourdeau P, Farge D, Beckers M. et al. International clinical practice guidelines for the treatment and prophylaxis of thrombosis associated with central venous catheters in patients with cancer. J Thromb Haemost 2013; 11 (01) 71-80
    CrossrefPubMedGoogle Scholar
  • 14 Farge D, Frere C, Connors JM. et al; International Initiative on Thrombosis and Cancer (ITAC) advisory panel. 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer. Lancet Oncol 2019; 20 (10) e566-e581
    CrossrefPubMedGoogle Scholar
  • 15 Wang TF, Zwicker JI, Ay C. et al. The use of direct oral anticoagulants for primary thromboprophylaxis in ambulatory cancer patients: Guidance from the SSC of the ISTH. J Thromb Haemost 2019; 17 (10) 1772-1778
    CrossrefPubMedGoogle Scholar
  • 16 Mandalà M, Falanga A, Roila F. ESMO Guidelines Working Group. Management of venous thromboembolism (VTE) in cancer patients: ESMO Clinical Practice Guidelines. Ann Oncol 2011; 22 (Suppl. 06) vi85-vi92
    CrossrefPubMedGoogle Scholar
  • 17 Key NS, Khorana AA, Kuderer NM. et al. Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol 2020; 38 (05) 496-520
    CrossrefPubMedGoogle Scholar
  • 18 Le Sage S, McGee M, Emed JD. Knowledge of venous thromboembolism (VTE) prevention among hospitalized patients. J Vasc Nurs 2008; 26 (04) 109-117
    CrossrefPubMedGoogle Scholar
  • 19 Mahé I, Chidiac J, Helfer H, Noble S. Factors influencing adherence to clinical guidelines in the management of cancer-associated thrombosis. J Thromb Haemost 2016; 14 (11) 2107-2113
    CrossrefPubMedGoogle Scholar
  • 20 Cohen J. A power primer. Psychol Bull 1992; 112 (01) 155-159
    CrossrefPubMedGoogle Scholar
  • 21 Lovakov A, Agadullina ER. Empirically derived guidelines for interpreting effect size in social psychology. Eur J Soc Psychol 2021; 51 (03) 485-504
    CrossrefPubMedGoogle Scholar
  • 22 Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009; 41 (04) 1149-1160
    CrossrefPubMedGoogle Scholar
  • 23 Sevestre MA, Belizna C, Durant C. et al; Carmen Investigators for the Groupe Francophone Thrombose et Cancer (GFTC). Compliance with recommendations of clinical practice in the management of venous thromboembolism in cancer: the CARMEN study. J Mal Vasc 2014; 39 (03) 161-168
    CrossrefPubMedGoogle Scholar
  • 24 Mansfield AS, Tafur AJ, Wang CE, Kourelis TV, Wysokinska EM, Yang P. Predictors of active cancer thromboembolic outcomes: validation of the Khorana score among patients with lung cancer. J Thromb Haemost 2016; 14 (09) 1773-1778
    CrossrefPubMedGoogle Scholar
  • 25 Alzoubi KH, Khassawneh BY, Obeidat B, Asfoor SS, Al-azzam SI. Awareness of patients who undergo cesarean section about venous thromboembolism prophylaxis. J Vasc Nurs 2013; 31 (01) 15-20
    CrossrefPubMedGoogle Scholar
  • 26 Haymes A. Venous thromboembolism: patient awareness and education in the pre-operative assessment clinic. J Thromb Thrombolysis 2016; 41 (03) 459-463
    CrossrefPubMedGoogle Scholar