Z Geburtshilfe Neonatol 2022; 226(03): 193-196
DOI: 10.1055/a-1727-6309
Original Article

Cystatin C Concentration During the First Three Postnatal Days in Healthy Term Newborns

1   Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
2   Clinical Biochemistry, University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina
,
Dunja Rogic
3   Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia
4   Department of Medical Biochemistry and Hematology, University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
,
Ivanka Mikulic
1   Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
2   Clinical Biochemistry, University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina
,
5   Department of Pediatrics, University of Mostar, School of Medicine, Mostra, Bosnia and Herzegovina
6   Department of Neonatology and Intensive Care Unit, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
,
Jerko Brzica
5   Department of Pediatrics, University of Mostar, School of Medicine, Mostra, Bosnia and Herzegovina
6   Department of Neonatology and Intensive Care Unit, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
,
Maja Pandza Topic
7   Department of Psychology, University of Mostar Faculty of Philosophy, Mostar, Bosnia and Herzegovina
,
Kristina Ljubić
1   Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
2   Clinical Biochemistry, University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina
,
Vajdana Tomic
8   Department of Obstetrics and Gynaecology, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
9   Department of Gynaecology, University of Mostar School of Medicine, Mostar, Bosnia and Herzegovina
› Author Affiliations

Abstract

Objective Cystatin C (Cys-C) concentration has not been examined sufficiently among healthy newborn population, particularly in terms of reference values. This study aimed to establish gender-, postnatal age- and birth weight-specific Cys-C concentration for healthy term newborns. Its objective was also to examine if there were any differences between our measured concentration and the reference interval established by the CALIPER study.

Methods Serum samples from a total of 90 healthy term newborns were used to determine Cys-C concentration. Cys-C was measured within first three days of birth using particle-enhanced turbidimetric immunoassay (PETIA) on the Architect plus ci8200 analyzer.

Results Median concentration of the Cys-C was 2.05 mg/L. There were no statistically significant differences in Cys-C concentration regarding gender (p=0.779), birth weight (p=0.505), postnatal age (p=0.512) or Apgar score (p=0.799). The value of the 2.5th and 97.5th percentile for Cys-C concentrations for girls was 0.93–3.15 mg/L and for boys it was 1.5–3.36 mg/L.

Conclusion Cys-C concentration in healthy term newborns does not depend on gender, birth weight, postnatal age, or Apgar score. Our measured concentration range of CyS-C in healthy newborns turned out to be slightly wider than the interval determined in the CALIPER study.



Publication History

Received: 21 September 2021

Accepted: 10 December 2021

Article published online:
26 January 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
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  • References

  • 1 Olafsson I. The human cystatin C gene promoter: functional analysis and identification of heterogeneous mRNA. Scand J Clin Lab Invest 1995; 55: 597-607
  • 2 Otukesh H, Hoseini R, Rahimzadeh N. et al. Glomerular function in neonates. Iran J Kidney Dis 2012; 6: 166-172
  • 3 den Bakker E, Gemke RJBJ, Bökenkamp A. Endogenous markers for kidney function in children: a review. Crit Rev Clin Lab Sci 2018; 55: 163-183
  • 4 Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 2002; 40: 221-226
  • 5 Roos JF, Doust J, Tett SE. et al. Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children – a meta-analysis. Clin Biochem 2007; 40: 383-391
  • 6 Nakhjavan-Shahraki B, Yousefifard M, Ataei N. et al. Accuracy of cystatin C in prediction of acute kidney injury in children; serum or urine levels: which one works better? A systematic review and meta-analysis. BMC Nephrol 2017; 18: 120
  • 7 Muhari-Stark E, Burckart GJ. Glomerular filtration rate estimation formulas for pediatric and neonatal use. J Pediatr Pharmacol Ther 2018; 23: 424-431
  • 8 Adeli K, Higgins V, Trajcevski K. et al. The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Crit Rev Clin Lab Sci 2017; 54: 358-413
  • 9 Spong CY. Defining term pregnancy: recommendations from the Defining Term Pregnancy Workgroup. JAMA 2013; 309: 2445-2446
  • 10 Pregnancy, childbirth, postpartum and newborn care: a guide for essential practice – 3rd ed. World Health Organization 2015
  • 11 Treiber M, Gorenjak M, Pecovnik Balon B. Serum cystatin-C as a marker of acute kidney injury in the newborn after perinatal hypoxia/asphyxia. Ther Apher Dial 2014; 18: 57-67
  • 12 Bökenkamp A, Domanetzki M, Zinck R. et al. Reference values for cystatin C serum concentrations in children. Pediatr Nephrol 1998; 12: 125-129
  • 13 Madise-Wobo AD, Gbelee OH, Solarin A. et al. Serum cystatin C levels in healthy Nigerian neonates: Is there a need for normative values in Nigerian babies?. Saudi J Kidney Dis Transpl 2017; 28: 1247-1255
  • 14 Olayinka RI, Ayodele OS, Timothy OA. et al. Determination of glomerular filtration rate using cystatin C in healthy Nigerian newborns. Alex J Med 2019; 55: 89-94
  • 15 Wilhelm-Bals A, Combescure C, Chehade H. et al. Variables of interest to predict glomerular filtration rate in preterm newborns in the first days of life. Pediatr Nephrol 2020; 35: 703-712
  • 16 Kandasamy Y, Rudd D, Smith R. The relationship between body weight, cystatin C and serum creatinine in neonates. J Neonatal Perinatal Med 2017; 10: 419-423
  • 17 Yata N, Uemura O, Honda M. et al. Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays. Clin Exp Nephrol 2013; 17: 872-876
  • 18 Tong C, Liu Y, Wu Y. et al. Gestational and age-specific cystatin c reference intervals for newborns. Am J Perinatol 2021; DOI: 10.1055/s-0041-1724000.
  • 19 Demirel G, Celik IH, Canpolat FE. et al. Reference values of serum cystatin C in very low-birthweight premature infants. Acta Paediatr 2013; 102: e4-e7
  • 20 Elmas AT, Tabel Y, Elmas ON. Reference intervals of serum cystatin C for determining cystatin C-based glomerular filtration rates in preterm neonates. J Matern Fetal Neonatal Med 2013; 26: 1474-1478
  • 21 Dorum S, Silfeler I, Dorum BA. et al. Reference values of serum cystatin-C for full-term and preterm neonates in Istanbul. Indian J Pediatr 2012; 79: 1037-1042
  • 22 Demirel G, Celik IH, Canpolat FE. et al. Reference values of serum cystatin C in very low-birthweight premature infants. Acta Paediatr 2013; 102: e4-e7
  • 23 Lee JH, Hahn WH, Ahn J. et al. Serum cystatin C during 30 postnatal days is dependent on the postconceptional age in neonates. Pediatr Nephrol 2013; 28: 1073-1078