Update Breast Cancer 2021 Part 5 – Advanced Breast Cancer

Diana Lüftner; Florian Schütz; Elmar Stickeler; Peter A. Fasching; Wolfgang Janni; Cornelia Kolberg-Liedtke; Hans-Christian Kolberg; Christoph Thomssen; Volkmar Müller; Tanja N. Fehm; Erik Belleville; Simon Bader; Michael Untch; Manfred Welslau; Marc Thill; Hans Tesch; Nina Ditsch; Michael P. Lux; Achim Wöckel; Bahriye Aktas; Andreas Schneeweiss; Rachel Würstlein; Andreas D. Hartkopf

doi:10.1055/a-1724-9569

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2022; 82(02): 215-225
DOI: 10.1055/a-1724-9569

GebFra Science

Review/Übersicht

Update Mammakarzinom 2021 Teil 5 – fortgeschrittenes Mammakarzinom

Article in several languages: English | deutsch

Diana Lüftner

¹Charité University Hospital, Department of Hematology, Oncology and Tumour Immunology, University Medicine Berlin, Berlin, Germany

,

Florian Schütz

²Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Elmar Stickeler

³Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen, Germany

,

Peter A. Fasching

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Wolfgang Janni

⁵Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Cornelia Kolberg-Liedtke

⁶Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany

⁷palleos healthcare, Wiesbaden, Germany

⁸Phaon Scientific, Wiesbaden, Germany

,

Hans-Christian Kolberg

⁹Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Christoph Thomssen

¹⁰Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

,

Volkmar Müller

¹¹Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Tanja N. Fehm

¹²Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany

,

Erik Belleville

¹³ClinSol GmbH & Co KG, Würzburg, Germany

,

Simon Bader

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Michael Untch

¹⁴Clinic for Gynecology and Obstetrics, Breast Cancer Center, Genecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany

,

Manfred Welslau

¹⁵Onkologie Aschaffenburg, Aschaffenburg, Germany

,

Marc Thill

¹⁶Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt am Main, Germany

,

Hans Tesch

¹⁷Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany

,

Nina Ditsch

¹⁸Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany

,

Michael P. Lux

¹⁹Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany

,

Achim Wöckel

²⁰Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

,

Bahriye Aktas

²¹Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Leipzig, Leipzig, Germany

,

Andreas Schneeweiss

²²National Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany

,

Rachel Würstlein

²³Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany

,

Andreas D. Hartkopf

²⁴Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

› Author Affiliations

Abstract

Zusammenfassung

Trotz der COVID-19-Pandemie und weitgehend virtueller Kongresse schreitet die Innovation in Bezug auf die Behandlung von Patientinnen mit Mammakarzinom mit ungebremster Geschwindigkeit fort. Dieser Übersichtsartikel fasst die aktuellen Entwicklungen zusammen. Die ersten Daten zum Gesamtüberleben für eine Therapie mit einem CDK4/6-Inhibitor in Kombination mit einem Aromatasehemmer bei nicht vorbehandelten, postmenopausalen Patientinnen in der ersten fortgeschrittenen Therapielinie wurden veröffentlicht. Ebenso zeigte eine Studie, die Trastuzumab-Deruxtecan mit Trastuzumab-Emtansin verglich, einen deutlichen Vorteil in Bezug auf das progressionsfreie Überleben. Die Kenntnisse über Biomarker, die eine Therapie mit einem Checkpoint-Inhibitor besonders effektiv machen, nehmen zu, und neue Substanzen wie die oralen selektiven Östrogenrezeptor-Destabilisatoren (SERDs) halten Einzug in die klinische Entwicklung und schließen die ersten Phase-III-Studien ab.

Schlüsselwörter

BRCA (breast cancer associated gene) - Genetik - Her-2/neu (humaner epidermaler Wachstumsfaktor-Rezeptor) - Hormonrezeptor - Mammakarzinom - Brust - Mamma

Full Text

References

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