CC BY-NC-ND 4.0 · Planta Medica International Open 2022; 9(01): e23-e33
DOI: 10.1055/a-1712-7978
Original Papers

Biosynthesis and Chemopreventive Potential of Jute (Corchorus capsularis and C. olitorius) Flavonoids and Phylogeny of Flavonoid Biosynthesis Pathways

Pratik Satya
1   ICAR-Central Research Institute for Jute and Allied Fibres, Barrackpore, Kolkata, India
Debabrata Sarkar
1   ICAR-Central Research Institute for Jute and Allied Fibres, Barrackpore, Kolkata, India
Amitava Chatterjee
2   Faculty Centre of Integrated Rural Development & Management, Ramakrishna Mission Vivekananda Educational and Research Institute, Narendrapur, Kolkata, India
Srikumar Pal
3   Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, Nadia, West Bengal, India
Soham Ray
1   ICAR-Central Research Institute for Jute and Allied Fibres, Barrackpore, Kolkata, India
Laxmi Sharma
1   ICAR-Central Research Institute for Jute and Allied Fibres, Barrackpore, Kolkata, India
Suman Roy
1   ICAR-Central Research Institute for Jute and Allied Fibres, Barrackpore, Kolkata, India
Amit Bera
1   ICAR-Central Research Institute for Jute and Allied Fibres, Barrackpore, Kolkata, India
Srinjoy Ghosh
1   ICAR-Central Research Institute for Jute and Allied Fibres, Barrackpore, Kolkata, India
Jiban Mitra
1   ICAR-Central Research Institute for Jute and Allied Fibres, Barrackpore, Kolkata, India
Gouranga Kar
1   ICAR-Central Research Institute for Jute and Allied Fibres, Barrackpore, Kolkata, India
Nagendra Kumar Singh
4   ICAR-National Institute for Plant Biotechnology, Pusa Campus, New Delhi, India
› Author Affiliations


Flavonoids are valuable phytochemicals for human health and nutrition. Jute (Corchorus capsularis and C. olitorius), a vegetable rich in phenolics and flavonoids, is globally consumed for its health benefit, but the biosynthesis pathways and metabolic profiles of its flavonoids are poorly characterized. Elucidating the flavonoid biosynthesis pathways would augment the broader use of jute, including targeted synthesis of its specific flavonoids. We reconstructed the core flavonoid biosynthesis pathways in jute by integrating transcriptome mining, HPLC and flavonoid histochemistry. In C. capsularis (white jute), the flavonoid biosynthesis pathways’ metabolic flux was driven toward the biosynthesis of proanthocyanidins that mediate the acquisition of abiotic stress tolerance. However, higher levels of flavonols in C. olitorius (tossa jute) render it more suitable for nutritional and medicinal use. Jute flavonoid extract exhibited in vitro inhibition of matrix metalloproteinase-2, suggesting its potential chemopreventive and immunity-boosting roles. Using the flavonoid biosynthesis pathways profiles of 93 plant species, we reconstructed the flavonoid biosynthesis pathways phylogeny based on distance-based clustering of reaction paths. This reaction-path flavonoid biosynthesis pathways phylogeny was quite distinct from that reconstructed using individual gene sequences. Our flavonoid biosynthesis pathways-based classification of flavonoid groups corroborates well with their chemical evolution, suggesting complex, adaptive evolution of flavonoid biosynthesis pathways, particularly in higher plants.

Supplementary Material

Publication History

Received: 10 July 2021
Received: 08 October 2021

Accepted: 18 November 2021

Article published online:
07 February 2022

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