Abstract
Acne is a skin condition arising from excess sebum production and microbial overgrowth
within the pilosebaceous unit. Several commercial essential oils have shown promising
activity against acne-related pathogens. Due to their volatility and thermal instability,
the formulation of essential oils into commercial products remains a pharmaceutical
challenge. Thus, this study aimed to develop a viable anti-acne topical treatment
as an oil-in-water emulsified lotion to overcome these challenges. Chrysopogon zizanioides (vetiver) displayed noteworthy antimicrobial activity with a mean minimum inhibitory
concentration of 0.14 mg/mL against Cutibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes. Emulsified lotions containing C. zizanioides were developed through the hydrophilic-lipophilic balance approach. At tested hydrophilic-lipophilic
balance values of 8, 9, and 10, C. zizanioides emulsified
lotions displayed maximum stability at hydrophilic-lipophilic balance 9 with
a minimum change in mean droplet size and polydispersity index of 20.61 and 33.33%,
respectively, over 84 days. The C. zizanioides emulsified lotion at optimum hydrophilic-lipophilic balance 9 completely inhibited
the growth of C. acnes and killed S. aureus, S. epidermidis, and S. pyogenes within 24 h. Additionally, the lotion retained antimicrobial activity against these
test micro-organisms over the 84-day stability test period. Thus, the C. zizanioides emulsified lotion demonstrated physical stability and antimicrobial efficiency, making
it an ideal natural product anti-acne treatment.
Key words
acne - essential oil -
Vetiveria zizanioides
- HLB - emulsion - stability
