Nickel-Catalyzed Asymmetric Synthesis of P-Stereogenic Vinyl Phosphines

Abstract

Addition reaction to alkynes is an efficient strategy for constructing valuable alkenyl compounds. However, the elusive regioselectivity has been a persistent challenge. In the context of hydrophosphination reaction which could afford valuable P-stereogenic phosphines, the control of enantioselectivity as well as regioselectivity were especially tricky. Here, we highlighted our recent work on the nickel-catalyzed regio- and enantioselective hydrophosphination of unactivated alkynes with in situ generated secondary phosphines.

1 Introduction

2 Hydrophosphination of Alkynes

3 Derivatization Reactions

4 Mechanism Research

5 Summary and Outlook

Key words

P-stereogenic - phosphine compounds - nickel catalysis - hydrophosphination - transition metals

• References and Notes

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