Open Access
CC BY-NC-ND 4.0 · Horm Metab Res 2021; 53(12): 771-778
DOI: 10.1055/a-1693-8356
Review

Effects of Lipid Overload on Heart in Metabolic Diseases

An Yan
1   Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Guinan Xie
1   Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Xinya Ding
1   Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Yi Wang
1   Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Liping Guo
2   Tianjin Academy of Traditional Chinese Medicine, Tianjin, China
› Author Affiliations

Funding Information This work was supported by Tianjin Postgraduate Research and Innovation Project (2020YJSB196).
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Abstract

Metabolic diseases are often associated with lipid and glucose metabolism abnormalities, which increase the risk of cardiovascular disease. Diabetic cardiomyopathy (DCM) is an important development of metabolic diseases and a major cause of death. Lipids are the main fuel for energy metabolism in the heart. The increase of circulating lipids affects the uptake and utilization of fatty acids and glucose in the heart, and also affects mitochondrial function. In this paper, the mechanism of lipid overload in metabolic diseases leading to cardiac energy metabolism disorder is discussed.



Publication History

Received: 16 August 2021

Accepted after revision: 29 October 2021

Article published online:
10 December 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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