Das therapeutische Potenzial von Picrorhiza kurroa bei der Behandlung von Lebererkrankungen

Zusammenfassung

Die Wirksamkeit von Naturstoffen hinsichtlich einer leberschützenden Aktivität wurde in der Wissenschaftsliteratur bereits häufig beschrieben. In letzter Zeit wächst in Europa das Interesse an pflanzlichen Stoffen, deren therapeutische Wirksamkeit durch die östliche Medizin (u. a. der ayurvedischen Medizin) bestätigt wird. Ein Beispiel für eine aus der ayurvedischen Medizin stammende Droge mit Heilpotenzial bei Lebererkrankungen ist die Wurzel und das Rhizom von Picrorhiza kurroa (zur Familie der Scrophulariaceae gehörend). Das Ziel dieser Übersichtsarbeit ist, den aktuellen Wissensstand über diesen natürlichen Rohstoff, seine chemische Zusammensetzung, das therapeutische Potenzial bei der Behandlung von Leberbeschwerden, die Toxizität und die Anwendungssicherheit zusammenzufassen.

Abstract

The effectiveness of natural products in the context of hepatoprotective activity has been widely described in the scientific literature. Recently, Asian herbal drugs have become more and more popular in Europe if their therapeutic effectiveness is confirmed by Eastern medicine, e. g., Ayurveda. An example of a plant material derived from Ayurvedic medicine with healing potential in liver diseases is the root and rhizome of Picrorhiza kurroa, which belongs to the Scrophulariaceae family. This review summarizes the current state of knowledge about this herbal drug, its chemical composition, therapeutic potential in the treatment of liver ailments, toxicity and safety of use.

Schlüsselwörter

Picrorhiza kurroa - Lebererkrankungen - ayurvedische Medizin

Key words

Picrorhiza kurroa - liver disease - Ayurvedic medicine

Publikationsverlauf

Artikel online veröffentlicht:
09. März 2022

• Literatur

• 1 Banerjee D, Maity B, Nag SK. et al. Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration. BMC Complement Altern Med 2008; 8: 3 DOI: 10.1186/1472-6882-8-3.
• 2 Bhardwaj A, Sharma A, Cooper R. A comprehensive phytochemical, ethnomedicinal, pharmacological ecology and conservation status of Picrorhiza kurroa Royle ex Benth. An endangered Himalayan medicinal plant. Process Biochem 2021; 109: 72-86 DOI: 10.1016/j.procbio.2021.07.003.
• 3 Bigoniya P, Shukla A, Singh CS. Evaluation of hepatic microsomal enzyme functional integrity on Picroliv pretreatment against CCl4 induced hepatotoxicity. Int J Pharm 2010; 6: 200-207
• 4 Bohraa N, Prasad P, Tewari G, Tewaria LM. Variation in picrotin and picrotoxin content of Picrorhiza kurroa Royle ex Benth rhizomes from Garhwal Himalaya. J Indian Chem Soc 2015; 92: 375-378 DOI: 10.5281/zenodo.5678664.
• 5 Girish C, Koner BC, Jayanthi S. et al. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam Clin Pharmacol 2009; 23: 735-745 DOI: 10.1111/j.1472-8206.2009.00722.x.
• 6 Girish C, Pradhan SC. Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice. J Pharmacol Pharmacother 2012; 3: 149-155 DOI: 10.4103/0976-500X.95515.
• 7 Husain GM, Singh PN, Kumar V. Antidiabetic activity of standardized extract of Picrorhiza kurroa in rat model of NIDDM. Drug Discov Ther 2009; 3: 88-92
• 8 Jeena KJ, Joy KL, Kuttan R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett 1999; 136: 11-16 DOI: 10.1016/s0304-3835(98)00294-8.
• 9 Jeyakumar R, Rajesh R, Rajaprabhu D. et al. Hepatoprotective effect of Picrorrhiza kurroa on antioxidant defense system in antitubercular drugs induced hepatotoxicity in rats. Afr J Biotechnol 2009; 8: 1314-1315
• 10 Krupashree K, Hemanth Kumar K, Rachitha P. et al. Chemical composition, antioxidant and macromolecule damage protective effects of Picrorhiza kurroa Royle ex Benth. S Afr J Bot 2014; 94: 249-254 DOI: 10.1016/j.sajb.2014.07.001.
• 11 Kumar S, Patial V, Soni S. et al. Picrorhiza kurroa enhances β-Cell mass proliferation and insulin secretion in streptozotocin evoked β-Cell damage in rats. Front Pharmacol 2017; 8: 537 DOI: 10.3389/fphar.2017.00537.
• 12 Kumar V, Mehrotra N, Lal J, Gupta RC. Pattern profiling of the herbal preparation picroliv using liquid chromatography-tandem mass spectrometry. J Chromatogr A 2004; 1045: 145-152 DOI: 10.1016/j.chroma.2004.06.021.
• 13 Mallick MN, Singh M, Parveen R. et al. HPTLC analysis of bioactivity guided anticancer enriched fraction of hydroalcoholic extract of Picrorhiza kurroa . Biomed Res Int 2015; 2015: 513875 DOI: 10.1155/2015/513875.
• 14 Morikawa T, Nakanishi Y, Inoue N. et al. Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth. Phytochemistry 2020; 169: 112185 DOI: 10.1016/j.phytochem.2019.112185.
• 15 Rastogi R, Srivastava AK, Rastogi AK. Long term effect of aflatoxin B(1) on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin. Phytother Res 2001; 15: 307-310 DOI: 10.1002/ptr.722.
• 16 Ray A, Chaudhuri SR, Majumdar B, Bandyopadhyay SK. Antioxidant activity of ethanol extract of rhizome of Picrorhiza kurroa on indomethacin induced gastric ulcer during healing. Indian J Clin Biochem 2002; 17: 44-51 DOI: 10.1007/BF02867970.
• 17 Saraswat B, Visen PK, Patnaik GK, Dhawan BN. Ex vivo and in vivo investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats. J Ethnopharmacol 1999; 66: 263-269 DOI: 10.1016/s0378-8741(99)00007-0.
• 18 Shetty SN, Mengi S, Vaidya R, Vaidya AD. A study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease. J Ayurveda Integr Med 2010; 1: 203-210 DOI: 10.4103/0975-9476.72622.
• 19 Singh M, Tiwari V, Jain A, Ghoshal S. Protective activity of picroliv on hepatic amoebiasis associated with carbon tetrachloride toxicity. Indian J Med Res 2005; 121: 676-682
• 20 Sinha S, Bhat J, Joshi M. et al. Hepatoprotective activity of Picrorhiza kurroa Royle Ex. Benth extract against alcohol cytotoxicity in mouse liver slice culture. Int J Green Pharmacy 2011; 5: 244-253 DOI: 10.4103/0973-8258.91234.
• 21 Stuppner H, Wagner H. New cucurbitacin glycosides from Picrorhiza kurrooa . Planta Med 1989; 55: 559-563 DOI: 10.1055/s-2006-962095.
• 22 Stuppner H, Müller EP, Wagner H. Cucurbitacins from Picrorhiza kurrooa . Phytochemistry 1991; 30: 305-310 DOI: 10.1016/0031-9422(91)84143-G.
• 23 Stuppner H, Moller EP. Cucurbitacins with unusual side chains from Picrorhiza kurroa . Phytochemistry 1993; 33: 1139-1145 DOI: 10.1016/0031-9422(93)85038-S.
• 24 Tabassam Q, Mehmood T, Ahmed S. et al. GC-MS metabolomics profiling and HR-APCI-MS characterization of potential anticancer compounds and antimicrobial activities of extracts from Picrorhiza kurroa roots. J Appl Biomed 2021; 19: 26-39 DOI: 10.32725/jab.2020.017.
• 25 Vivekanandan P, Gobianand K, Priya S. et al. Protective effect of picroliv against hydrazine-induced hyperlipidemia and hepatic steatosis in rats. Drug Chem Toxicol 2007; 30: 241-252 DOI: 10.1080/01480540701375216.