RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000134.xml
Diabetologie und Stoffwechsel 2021; 16(06): 469-472
DOI: 10.1055/a-1664-5136
DOI: 10.1055/a-1664-5136
DDG-Preisträger
Das Diabetes-Kaleidoskop: auf dem Weg zur Präzisionsmedizin im Diabetes – Ferdinand Bertram-Preis 2021 – eine Kurzübersicht des Preisträgers Robert Wagner

Hinführung
Der Diabetes mellitus ist durch eine chronische Hyperglykämie gekennzeichnet. Ursächlich für die Entstehung der Hyperglykämie können unterschiedliche Mechanismen stehen. Die letzte, im Jahr 2019 aktualisierte WHO Klassifikation des Diabetes beinhaltet 6 Hauptgruppen des Diabetes (s. [Tab. 1]) [1]. Über 90% aller Betroffenen fallen in die Kategorie Typ-2-Diabetes, die aber ätiologisch keine einheitliche Gruppe ist. Diese Heterogenität zeigt sich durch unterschiedliche Krankheitsverläufe mit unterschiedlicher Ausprägung der Hyperglykämie und der Neigung zu Komplikationen.
Publikationsverlauf
Artikel online veröffentlicht:
22. Dezember 2021
© 2021. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 World Health Organization. Classification of diabetes mellitus. Geneva: World Health Organization; 2019. Im Internet. https://apps.who.int/iris/handle/10665/325182
- 2 Almgren P, Lehtovirta M, Isomaa B. et al. Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study. Diabetologia 2011; 54: 2811-2819
- 3 Wagner R, Staiger H. Genetik des Typ-2-Diabetes. Diabetologe 2019; 15: 267-277
- 4 Wagner R, Dudziak K, Herzberg-Schäfer SA. et al. Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin. PLoS ONE 2011; 6: e23639
- 5 Wagner R, Tabák ÁG, Fehlert E. et al. Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies. Scientific Reports 2017; 7: 15486
- 6 Claussnitzer M, Dankel SN, Kim KH. et al. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N Engl J Med 2015;
- 7 Wagner R, Hieronimus A, Lamprinou A. et al. Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans. Mol Metab 2014; 3: 676-680
- 8 Jaghutriz BA, Heni M, Lutz SZ. et al. Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion. Front Endocrinol (Lausanne) 2019; 10: 72
- 9 Linder K, Wagner R, Hatziagelaki E. et al. Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals. PLoS ONE 2012; 7: e38224
- 10 Fisher E, Boeing H, Fritsche A. et al. Whole-grain consumption and transcription factor-7-like 2 (TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk. Br J Nutr 2009; 101: 478-481
- 11 Li J, Li X, Zhang S. et al. Gene-Environment Interaction in the Era of Precision Medicine. Cell 2019; 177: 38-44
- 12 Ahlqvist E, Storm P, Käräjämäki A. et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol 2018; 6: 361-369
- 13 Zaharia OP, Strassburger K, Strom A. et al. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol 2019; 7: 684-694
- 14 Dennis JM, Shields BM, Henley WE. et al. Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data. The Lancet Diabetes & Endocrinology 2019; 0
- 15 Fritsche A, Heni M, Peter A. et al. Considering Insulin Secretory Capacity as Measured by a Fasting C-Peptide/Glucose Ratio in Selecting Glucose-Lowering Medications. Exp Clin Endocrinol Diabetes 2020;
- 16 Rathmann W, Haastert B, Icks A. et al. High prevalence of undiagnosed diabetes mellitus in Southern Germany: Target populations for efficient screening. The KORA survey 2000. Diabetologia 2003; 46: 182-189
- 17 Gedebjerg A, Almdal TP, Berencsi K. et al. Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort. J Diabetes Complications 2018; 32: 34-40
- 18 Tabák AG, Herder C, Rathmann W. et al. Prediabetes: a high-risk state for diabetes development. Lancet 2012; 379: 2279-2290
- 19 Wagner R, Heni M, Tabák AG. et al. Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes. Nat Med 2021; 27: 49-57
- 20 Stefan N, Kantartzis K, Machann J. et al. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 2008; 168: 1609-1616
- 21 Wagner R, Machann J, Lehmann R. et al. Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes. Diabetologia 2012; 55: 2054-2058
- 22 Wagner R, Machann J, Guthoff M. et al. The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A. Sci Rep 2017; 7: 2261
- 23 Gerst F, Wagner R, Kaiser G. et al. Metabolic crosstalk between fatty pancreas and fatty liver: effects on local inflammation and insulin secretion. Diabetologia 2017; 60: 2240-2251
- 24 Wagner R, Jaghutriz BA, Gerst F. et al. Pancreatic steatosis associates with impaired insulin secretion in genetically predisposed individuals. J Clin Endocrinol Metab 2020;