Synlett 2022; 33(01): 27-33
DOI: 10.1055/a-1662-7783

Long Journey on Daptomycin

Xuechen Li
I would like to express my gratitude to the funding agency for their generous supports over the years, including the Research Grants Council, University Grants Committee of Hong Kong (Grant Numbers C7038-15G, C5036-16G, and AoE/P-705/16), the Cubist Pharmaceutical Inc., the Peacock Program – Project Development Fund of Shenzhen, the National Basic Research Program of China, and the University of Hong Kong.


Over the past more than ten years, my laboratory has been engaged in the total synthesis, medicinal chemistry, and chemical biology studies on daptomycin. Our efforts are expected to advance new understanding of this effective cyclic lipodepsipeptide antibiotic. In this Account, this long journey is presented.

1 Introduction

2 Total Synthesis of Daptomycin

3 Medicinal Chemistry of Daptomycin

4 Molecular Comparison of Daptomycin and Kynomycin

5 New Insight into How Daptomycin Exerts Bactericidal Effect

6 Conclusion

Publication History

Received: 03 September 2021

Accepted after revision: 06 October 2021

Accepted Manuscript online:
06 October 2021

Article published online:
26 October 2021

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
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