Frequency of synchronous malignant liver lesions initially detected by ultrasound in patients with newly diagnosed underlying non-hematologic malignant disease: a retrospective study in 434 patients

Ehsan Safai Zadeh; Martin Axel Baumgarten; Christoph F. Dietrich; Christian Görg; Albrecht Neesse; Corinna Trenker; Amjad Alhyari

doi:10.1055/a-1649-8857

Zeitschrift für Gastroenterologie, Table of Contents

Z Gastroenterol 2022; 60(04): 586-592
DOI: 10.1055/a-1649-8857

Originalarbeit

Frequency of synchronous malignant liver lesions initially detected by ultrasound in patients with newly diagnosed underlying non-hematologic malignant disease: a retrospective study in 434 patients

Häufigkeit von synchronen malignen Leberläsionen detektiert im Ultraschall bei Patienten mit neu diagnostizierter nicht-hämatologischer maligner Erkrankung: eine retrospektive Studie bei 434 Patienten

Authors

Ehsan Safai Zadeh ‡

¹Interdisciplinary Center of Ultrasound Diagnostics, University Hospital Giessen and Marburg, Philipps University Marburg, Marburg, Germany
Martin Axel Baumgarten‡

¹Interdisciplinary Center of Ultrasound Diagnostics, University Hospital Giessen and Marburg, Philipps University Marburg, Marburg, Germany
Christoph F. Dietrich

²Department Allgemeine Innere Medizin (DAIM), Beau Site, Salem und Permanence, Bern, Kliniken Hirslanden Bern, Bern, Switzerland
Christian Görg

¹Interdisciplinary Center of Ultrasound Diagnostics, University Hospital Giessen and Marburg, Philipps University Marburg, Marburg, Germany

³Gastroenterology, Endocrinology, Metabolism and Clinical Infectiology, University Hospital Giessen and Marburg, Philipps University Marburg, Marburg/ Lahn, Germany
Albrecht Neesse

⁴Gastroenterology,Gastrointestinal Oncology and Endocrinology, University Medicine Goettingen, Göttingen, Germany
Corinna Trenker

⁵Haematology, Oncology and Immunology, University Hospital Giessen and Marburg, Philipps University Marburg, Marburg, Germany
Amjad Alhyari

³Gastroenterology, Endocrinology, Metabolism and Clinical Infectiology, University Hospital Giessen and Marburg, Philipps University Marburg, Marburg/ Lahn, Germany

Abstract

Introduction This study described the frequency of malignant synchronous focal liver lesions (FLLs) in patients with newly diagnosed non-hematologic malignant disease.

Methods From June 2013 to January 2017, 434 patients with synchronous FLLs and newly diagnosed underlying malignant disease were included in the study. The diagnosis of the FLLs was made by histology and/or contrast-enhanced imaging. The final medical report was used for analysis in the study.

Results Of the 434 liver lesions, 258 (59.4%) were malignant and 176 (40.6%) benign. All malignant lesions were metastases. The benign liver lesions were comprised of 93 cysts (21.4%), 52 hemangiomas (12.0%), 20 focal fatty sparing (4.6%), 4 focal nodular hyperplasia (0.9%), 3 unspecified benign lesions (0.7%), 2 regenerative nodules (0.5%), 1 calcification (0.2%), and 1 adenoma (0.2%). Diseases with the highest percentage frequency of synchronous malignant FLLs were cholangiocarcinoma with 86.7%, neuroendocrine tumor with 72.7%, and pancreatic carcinoma with 72.0%. Gastric carcinoma (33.3%), breast carcinoma (44.4%), and urothelial cell carcinoma (45.5%) were the diseases with the lowest percentage frequency of synchronous malignant FLLs.

Conclusion In total, the frequency of malignant synchronous FLLs in newly diagnosed non-hematologic malignant disease was 59.4%. In particular, cholangiocarcinoma, neuroendocrine tumor, and pancreatic carcinoma were the diseases with the highest rate of synchronous malignant FLLs.

Zusammenfassung

Ziel Beschreibung der Häufigkeit maligner synchroner fokaler Leberläsionen (FLLs) bei Patienten mit neu diagnostizierter nichthämatologischer maligner Erkrankung.

Material und Methoden Von Juni 2013 bis Januar 2017 wurden 434 konsekutive Patienten mit synchronen FLLs und neu diagnostizierter maligner Grunderkrankung in die Studie eingeschlossen. Die Diagnose der FLLs wurde durch Histologie und/oder Kontrastmittelbildgebung gestellt. Der finale Arztbrief wurde für die Analyse in der Studie verwendet.

Ergebnisse Von den 434 Leberläsionen waren 258 (59,4%) maligne und 176 (40,6%) benigne. Alle bösartigen Läsionen waren Metastasen. Bei den gutartigen Leberläsionen handelte es sich um 93 Zysten (21,4 %), 52 Hämangiome (12,0 %), 20 fokale Fettverteilungsstörung (4,6 %), 4 fokale noduläre Hyperplasien (0,9 %), 3 nicht näher spezifizierte gutartige Läsionen (0,7 %), 2 regenerative Knötchen (0,5 %), 1 Verkalkung (0,2 %) und 1 Adenom (0,2 %). Erkrankungen mit der höchsten prozentualen Häufigkeit von synchronen malignen FLLs waren das cholangiozelluläre Karzinom mit 86,7%, der neuroendokrine Tumor mit 72,7% und das Pankreaskarzinom mit 72,0%. Magenkarzinom (33,3%), Mammakarzinom (44,4%) und Urothelzellkarzinom (45,5%) waren die Erkrankungen mit der geringsten prozentualen Häufigkeit synchroner maligner FLLs.

Schlussfolgerung Insgesamt betrug die absolute Häufigkeit von malignen synchronen FLLs bei neu diagnostizierten nichthämatologischen malignen Erkrankungen 59,4 %. Insbesondere cholangiozelluläre Karzinome, NETs und das Pankreaskarzinom zeigten die höchste Rate an malignen synchronen fokalen Leberläsionen.

Schlüsselwörter

nicht-hämatologische maligne Erkrankung - seed and soil - Tumorentität - fokale Leberläsionen - Ultraschall

Keywords

non-hematologic malignant disease - seed and soil - tumor entity - focal liver lesions - ultrasound

Full Text

References

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