Klin Padiatr 2022; 234(03): 172-173
DOI: 10.1055/a-1647-2687
Short Communication

Infant Acute Myeloid Leukemia Presenting as Acute Appendicitis: A Case Report

Appendizitis als Erstmanifestation einer akuten myeloischen Leukämie im Säuglingsalter: Ein Fallbericht
Urs Mücke
1   Pediatric Surgery, Hannover Medical School, Hannover, Germany
Alejandro Hofmann
2   Pathology, Hannover Medical School, Hannover, Germany
Stefanie Langreen
2   Pathology, Hannover Medical School, Hannover, Germany
Miriam Odensass
3   Pediatric Hematology and Oncology, Hannover Medical School Centre for Paediatrics and Adolescent Medicine, Hannover, Germany
Anna Partheil
1   Pediatric Surgery, Hannover Medical School, Hannover, Germany
› Institutsangaben


Acute leukemia is among the most common malignancy in infancy and childhood. The distinction between lymphoblastic and myeloid leukemia is crucial for appropriate therapy. Acute myeloid leukemia (AML) is less common than lymphoblastic leukemia, but sometimes presents with equally nonspecific symptoms at initial diagnosis. Timely detection of the disease affects treatment and prognosis.

At initial diagnosis, leukemias are often recognized by the consequences of the pathologically altered blood cells: dysfunctional leukocytes cause susceptibility to infections, thrombocytopenia leads to petechiae or mucosal hemorrhage, anemia reduces the patients' physical resilience and causes pale skin coloration. Classic B symptoms (fever, night sweats, weight loss) are not regularly reported. Rarely, additional locoregional changes occur due to organ manifestations that ultimately lead to diagnosis. For example, AML via localized blast accumulation (myelosarcoma) can lead to swelling (e. g. orbita) or neurologic deficits (spine and spinal canal) at initial diagnosis. Manifestation via gastrointestinal tract complaints has also been described. Occasionally, appendicitis has occurred in children and adults as the first sign of AML. Myelosarcoma of the appendix has not yet been described in infancy.


Artikel online veröffentlicht:
22. Oktober 2021

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