Definition, Classification and Diagnosis of Diabetes Mellitus

Erwin Schleicher; Christian Gerdes; Astrid Petersmann; Dirk Müller-Wieland; Ulrich A. Müller; Guido Freckmann; Lutz Heinemann; Matthias Nauck; Rüdiger Landgraf

doi:10.1055/a-1624-2897

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2022; 130(S 01): S1-S8
DOI: 10.1055/a-1624-2897

German Diabetes Association: Clinical Practice Guidelines

Definition, Classification and Diagnosis of Diabetes Mellitus^[1]

Erwin Schleicher

¹Institute for Clinical Chemistry and Pathobiochemistry – Central Laboratory, University Hospital Tübingen, Germany

²German Center for Diabetes Research (DZD) München-Neuherberg, Germany

,

Christian Gerdes

³Department of Internal Medicine III, University Hospital Jena, Germany

,

Astrid Petersmann

⁴Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany

⁵Institute for Clinical Chemistry and Laboratory Medicine, University of Oldenburg, Germany

,

Dirk Müller-Wieland

⁶Department of Internal Medicine I, RWTH Aachen University, Germany

,

Ulrich A. Müller

⁷Practice for Endocrinology and Diabetology, Dr. Kielstein Ambulante Medizinische Versorgung GmbH, Jena, Germany

,

Guido Freckmann

⁸Institute for Diabetes Technology, Research and Development Company at the University of Ulm, Germany

,

Lutz Heinemann

⁹Science-Consulting in Diabetes GmbH, Kaarst, Germany

,

Matthias Nauck

⁴Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany

¹⁰DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany

,

Rüdiger Landgraf

¹¹German Diabetes Foundation (DDS) Düsseldorf, Germany

References
1 Deutsche Diabetes Gesellschaft und Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, Hrsg. S3-Leitlinie Gestationsdiabetes mellitus (GDM), Diagnostik, Therapie und Nachsorge. AWMF-Registernummer: 057-008. 2018; 2. Auflage: https://www.awmf.org/uploads/tx_szleitlinien/057-008l_S3_Gestationsdiabetes-mellitus-GDM-Diagnostik-Therapie-Nachsorge_2019-06.pdf Stand: 14.08.2019
2 „Richtlinie der Bundesärztekammer zur Qualitätssicherung laboratoriumsmedizinischer Untersuchungen“. Dtsch Arztebl International 2013; 110 (39): 1822
3 Pani LN. et al. Effect of aging on A1C levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004. Diabetes Care 2008; 31: 1991-1996
4 Pieri M, Pignalosa S, Zenobi R. et al. Reference intervals for HbA_1c partitioned for gender and age: a multicenter study. Acta Diabetol 2016; 53: 1053-1056
5 Roth J, Müller N, Lehmann T. et al. HbA_1c and Age in Non-Diabetic Subjects: An Ignored Association. Exp Clin Endocrinol Diabetes 2016; 124: 637-642
6 Ma Q, Liu H, Xiang G. et al. Association between glycated hemoglobin A_1c levels with age and gender in Chinese adults with no prior diagnosis of diabetes mellitus. Biomed Rep 2016; 4: 737-740
7 Wu L, Lin H, Gao J. et al. Effect of age on the diagnostic efficiency of HbA_1c for diabetes in a Chinese middle-aged and elderly population: The Shanghai Changfeng Study. PLoS One 2017; 12: e0184607
8 Qi J, Su Y, Song Q. et al. Reconsidering the HbA_1c Cutoff for Diabetes Diagnosis Based on a Large Chinese Cohort. Exp Clin Endocrinol Diabetes 2019. doi:10.1055/a-0833-8119
9 Masuch A. et al. Preventing misdiagnosis of diabetes in the elderly: age dependent HbA_1c reference intervals derived from two populationbased study cohorts. BMC Endocr Disord 2019; 19: 20
10 Ozarda Y, Sikaris K, Streichert T. et al. Distinguishing reference intervals and clinical decision limits – A review by the IFCC Committee on Reference Intervals and Decision Limits. Crit Rev Clin Lab Sci 2018; 55: 420-431
11 Buzzetti R, Zampetti S, Maddaloni E. et al. Adult-onset autoimmune diabetes: current knowledge and implications for management. Nat Rev Endocrinol 2017; 13: 674-686
12 Badenhoop K. MODY und andere monogenetische Diabetesformen. Diabetologe 2017; 13: 453-463
13 Bojunga J, Schlereth F. Type 3c diabetes mellitus-prevalence, diagnosis, special aspects of treatment. Diabetologe 2018; 14: 269-277
14 Kufeldt J. et al. Prevalence and Distribution of Diabetes Mellitus in a Maximum Care Hospital: Urgent Need for HbA_1c -Screening. Exp Clin Endocrinol Diabetes 2018; 126: 123-129
15 Gopal Peddinti G, Bergman M, Tuom T. et al. 1-Hour Post-OGTT Glucose Improves the Early Prediction of Type 2 Diabetes by Clinical and Metabolic Markers. J Clin Endocrinol Metab 2019; 104: 1131-1140
16 Manco M, Mari A, Petrie J. et al. One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort. Diabetologia 2019; 62: 544-548
17 Bergman M, Manco M, Sesti G. et al. Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose≥155 mg/dl (8.6 mmol/L). Diabetes Res Clin Pract 2018; 146: 18-33
18 Keutmann S, Zylla S, Dahl M. et al. Measurement Uncertainty Impacts Diagnosis of Diabetes Mellitus: Reliable Minimal Difference of Plasma Glucose Results. Diabetes Ther 2020; 11: 293-303

Definition, Classification and Diagnosis of Diabetes Mellitus[1]

Definition, Classification and Diagnosis of Diabetes Mellitus^[1]