pferde spiegel, Table of Contents pferde spiegel 2021; 24(04): 171-181DOI: 10.1055/a-1584-2428 CVE-Fortbildung Papillomvirusinfektion als Ursache von Hauttumoren beim Pferd Sabine Brandt Recommend Article Abstract Buy Article All articles of this category Papillomviren sind eine Familie kleiner DNS-Viren, die je nach Typ harmlose Hautveränderungen oder aber bestimmte Formen von Hautkrebs bei Wirbeltieren verursachen. Auch Pferde können an Papillomvirus-induzierten Hauttumoren erkranken. Full Text References Literatur 1 Campo MS. Introduction. In: Campo MS. Hrsg. Papillomavirus Research: From Natural History to Vaccines and Beyond. 1 ed. Norfolk, UK: Caister Academic Press; 2006: 1-2 2 Campo MS, Roden RB. Papillomavirus prophylactic vaccines: established successes, new approaches. J Virol 2010; 84 (03) 1214-1220 3 Campo MS. Bovine papillomavirus: old system, new lessons?. In: Campo MS. Hrsg. Papillomavirus Research: From Natural History to Vaccines and Beyond. 1 ed. Norfolk, UK: Caister Academic Press; 2006: 373-387 4 Doorbar J. The papillomavirus life cycle. J Clin Virol 2005; 32 (Suppl. 01) S7-15 5 Nasir L, Reid SWJ. Bovine papillomaviruses and equine sarcoids. In: Campo MS. Hrsg. Papillomavirus Research: From Natural History to Vaccines and Beyond. 1 ed. Norfolk, UK: Caister Academic Press; 2006: 389-397 6 Lunardi M, de Alcantara BK, Otonel RA, Rodrigues WB, Alfieri AF, Alfieri AA. Bovine papillomavirus type 13 DNA in equine sarcoids. J Clin Microbiol 2013; 51 (07) 2167-2171 7 Chambers G, Ellsmore VA, OʼBrien PM, Reid SW, Love S, Campo MS. et al. Association of bovine papillomavirus with the equine sarcoid. J Gen Virol 2003; 84 (05) 1055-1062 8 Hainisch EK, Brandt S. Equine Sarcoids. In: Robinson NE, Sprayberry KA. Hrsg. Robinsonʼs Current Therapy in Equine Medicine. 7 ed. St. Louis, Missouri, USA: Saunders Elsevier; 2015: 99 9 Marchetti B, Gault EA, Cortese MS, Yuan Z, Ellis SA, Nasir L. et al. Bovine papillomavirus type 1 oncoprotein E5 inhibits equine MHC class I and interacts with equine MHC I heavy chain. J Gen Virol 2009; 90 (12) 2865-2870 10 Yuan Z, Gault EA, Campo MS, Nasir L. Different contribution of bovine papillomavirus type 1 oncoproteins to the transformation of equine fibroblasts. J Gen Virol 2011; 92(Pt 4): 773-783 11 Knottenbelt DC. The Equine Sarcoid: Why Are There so Many Treatment Options?. Vet Clin North Am Equine Pract 2019; 35 (02) 243-262 12 Brandt S, Haralambus R, Schoster A, Kirnbauer R, Stanek C. Peripheral blood mononuclear cells represent a reservoir of bovine papillomavirus DNA in sarcoid-affected equines. J Gen Virol 2008; 89(Pt 6): 1390-1395 13 Brandt S, Haralambus R, Shafti-Keramat S, Steinborn R, Stanek C, Kirnbauer R. A subset of equine sarcoids harbours BPV-1 DNA in a complex with L1 major capsid protein. Virology 2008; 375 (02) 433-441 14 Nasir L, Brandt S. Papillomavirus associated diseases of the horse. Vet Microbiol 2013; 167(1 – 2): 159-167 15 Lancaster WD. Apparent lack of integration of bovine papillomavirus DNA in virus-induced equine and bovine tumor cells and virus-transformed mouse cells. Virology 1981; 108 (02) 251-255 16 Roden RB, Lowy DR, Schiller JT. Papillomavirus is resistant to desiccation. J Infect Dis 1997; 176 (04) 1076-1079 17 Bogaert L, Martens A, De Baere C, Gasthuys F. Detection of bovine papillomavirus DNA on the normal skin and in the habitual surroundings of horses with and without equine sarcoids. Res Vet Sci 2005; 79 (03) 253-258 18 Finlay M, Yuan Z, Burden F, Trawford A, Morgan IM, Campo MS. et al. The detection of Bovine Papillomavirus type 1 DNA in flies. Virus Res 2009; 144(1 – 2): 315-317 19 Kemp-Symonds JG. The detection and sequencing of bovine papillomavirus type 1 and 2 DNA from Musca autumnalis (Diptera: Muscidae) face flies infesting sarcoid-affected horses [MSc thesis]. London, UK: Royal Veterinary College; 2000 20 Olson Jr C, Cook RH. Cutaneous sarcoma-like lesions of the horse caused by the agent of bovine papilloma. Proc Soc Exp Biol Med 1951; 77 (02) 281-284 21 Ragland WL, Spencer GR. Attempts to relate bovine papilloma virus to the cause of equine sarcoid: equidae inoculated intradermally with bovine papilloma virus. Am J Vet Res 1969; 30 (05) 743-752 22 Voss JL. Transmission of equine sarcoid. Am J Vet Res 1969; 30 (02) 183-191 23 Hartl B, Hainisch EK, Shafti-Keramat S, Kirnbauer R, Corteggio A, Borzacchiello G. et al. Inoculation of young horses with bovine papillomavirus type 1 virions leads to early infection of PBMCs prior to pseudo-sarcoid formation. J Gen Virol 2011; 92(Pt 10): 2437-2445 24 Bogaert L, Martens A, Kast WM, Van Marck E, De Cock H. Bovine papillomavirus DNA can be detected in keratinocytes of equine sarcoid tumors. Vet Microbiol 2010; 146(3 – 4): 269-275 25 Brandt S, Tober R, Corteggio A, Burger S, Sabitzer S, Walter I. et al. BPV-1 infection is not confined to the dermis but also involves the epidermis of equine sarcoids. Vet Microbiol 2011; 150(1 – 2): 35-40 26 Wilson AD, Armstrong EL, Gofton RG, Mason J, De Toit N, Day MJ. Characterisation of early and late bovine papillomavirus protein expression in equine sarcoids. Vet Microbiol 2013; 162(2 – 4): 369-380 27 Byam-Cook KL, Henson FM, Slater JD. Treatment of periocular and non-ocular sarcoids in 18 horses by interstitial brachytherapy with iridium-192. Vet Rec 2006; 159 (11) 337-341 28 Espy BMK. How to Treat Equine Sarcoids by Autologous Implantation. AAEP Proceedings 2008; 54: 68-73 29 Rothacker CC, Boyle AG, Levine DG. Autologous vaccination for the treatment of equine sarcoids: 18 cases (2009–2014). Can Vet J 2015; 56 (07) 709-714 30 Koch C, Martens A, Hainisch EK, Schupbach G, Gerber V, Haspeslagh M. The clinical diagnosis of equine sarcoids – Part 1: Assessment of sensitivity and specificity using a multicentre case-based online examination. Vet J 2018; 242: 77-82 31 Haspeslagh M, Gerber V, Knottenbelt DC, Schupbach G, Martens A, Koch C. The clinical diagnosis of equine sarcoids-Part 2: Assessment of case features typical of equine sarcoids and validation of a diagnostic protocol to guide equine clinicians in the diagnosis of equine sarcoids. Vet J 2018; 240: 14-18 32 Haspeslagh M, Vlaminck LE, Martens AM. Treatment of sarcoids in equids: 230 cases (2008–2013). J Am Vet Med Assoc 2016; 249 (03) 311-318 33 Scott DW, Miller Jr. WH. Squamous cell carcinoma. In: Scott DW, Miller Jr WH. Hrsg. Equine Dermatology. 1 ed. St. Louis, Missouri, USA: Saunders Elsevier; 2003: 707-712 34 Scase T, Brandt S, Kainzbauer C, Sykora S, Bijmholt S, Hughes K. et al. Equus caballus papillomavirus-2 (EcPV-2): an infectious cause for equine genital cancer?. Equine Vet J 2010; 42 (08) 738-745 35 Sykora S, Brandt S. Papillomavirus infection and squamous cell carcinoma in horses. Vet J 2017; 223: 48-54 36 van den Top JG, de Heer N, Klein WR, Ensink JM. Penile and preputial tumours in the horse: a retrospective study of 114 affected horses. Equine Vet J 2008; 40 (06) 528-532 37 zur Hausen H. Papillomaviruses in the causation of human cancers – a brief historical account. Virology 2009; 384 (02) 260-265 38 Gardiol D, Kuhne C, Glaunsinger B, Lee SS, Javier R, Banks L. Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation. Oncogene 1999; 18 (40) 5487-5496 39 Nguyen ML, Nguyen MM, Lee D, Griep AE, Lambert PF. The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6ʼs induction of epithelial hyperplasia in vivo. J Virol 2003; 77 (12) 6957-6964 40 Sykora S, Samek L, Schonthaler K, Palm F, Borzacchiello G, Aurich C. et al. EcPV-2 is transcriptionally active in equine SCC but only rarely detectable in swabs and semen from healthy horses. Vet Microbiol 2012; 158(1 – 2): 194-198 41 Sykora S, Jindra C, Hofer M, Steinborn R, Brandt S. Equine papillomavirus type 2: An equine equivalent to human papillomavirus 16?. Vet J 2017; 225: 3-8 42 Huang LW, Chao SL, Lee BH. Integration of human papillomavirus type-16 and type-18 is a very early event in cervical carcinogenesis. J Clin Pathol 2008; 61 (05) 627-631 43 Olthof NC, Huebbers CU, Kolligs J, Henfling M, Ramaekers FC, Cornet I. et al. Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines. Int J Cancer 2015; 136 (05) E207-218 44 Pett M, Coleman N. Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?. J Pathol 2007; 212 (04) 356-367 45 Walline HM, Komarck CM, McHugh JB, Bellile EL, Brenner JC, Prince ME. et al. Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma. Mol Cancer Res 2016. 46 Knottenbelt DC, Pascoe RR. Disorders of the eye. In: Konttenbelt DC, Pascoe RR. edis Diseases and Disorders of the Horse. London, UK: Mosby; 1994: 327-331
