Symptome wie Diarrhö, Meteorismus und abdominale Schmerzen sind im
klinischen Alltag häufig. Die Ursache ist oft das Reizdarmsyndrom (RDS).
Während die Pathogenese noch unklar ist, wird die Pathophysiologie
zunehmend besser verstanden. Im klinischen Alltag stellt die Diagnostik und
Therapie des RDS eine große Herausforderung dar. Die heterogene
Symptomatik und der Mangel an validierten Biomarkern erfordert eine umfassende
Differenzialdiagnostik [1].
Abstract
Symptoms such as diarrhea, meteorism, and abdominal pain are common in everyday
clinical practice. The cause is often irritable bowel syndrome (IBS). While the
pathogenesis is still unclear, the pathophysiology of the disease is
increasingly better understood. Irritable bowel syndrome can be divided into
different subgroups. Particularly relevant for clinical practice are IBS with
predominant constipation (IBS-C), IBS with predominant diarrhea (IBS-D), and IBS
with mixed bowel habits (IBS-M). The diagnosis and therapy of IBS represent a
major challenge. The heterogeneous symptoms and the lack of validated biomarkers
require comprehensive differential diagnostics. This includes laboratory
diagnostic, checking for food allergies, endoscopy, abdominal sonography, H2
breath tests, homocholic acid taurine tests, and psychosomatic diagnostic. There
are different therapeutic approaches like nutrition therapy, administration of
probiotics and symptom-oriented drug therapies. This article aims to give an
overview of the diagnosis and therapy of IBSD and IBS-M in Germany with insights
and experiences from clinical practice.
Schlüsselwörter
Reizdarmsyndrom - S3-RDS-Leitlinie - Diagnostik - Therapie
irritable bowl syndrom - S3-guidline - Therapy - Diagnosis
