Tierarztl Prax Ausg K Kleintiere Heimtiere 2021; 49(04): 256-261
DOI: 10.1055/a-1543-4743
Original Article

Clinical effects of 2 commercially available diets on canine atopic dermatitis

Klinische Effekte von 2 kommerziellen Diätfuttermitteln bei Hunden mit atopischer Dermatitis
Teresa M. S. A. Boehm
1   Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Munich, Germany
,
Christoph J. Klinger
2   Tierklinik Stuttgart Plieningen, Veterinary Specialist Hospital, Stuttgart, Germany
,
Laura Udraite-Vovk
1   Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Munich, Germany
,
Christelle Navarro
3   Virbac, Companion Animals, Carros, France
,
Ralf S. Mueller
1   Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Munich, Germany
› Author Affiliations

Abstract

Objective Canine atopic dermatitis (CAD) is a common skin disease in dogs. Prior studies were able to determine beneficial effects of essential fatty acids (EFA) on the clinical signs of CAD. The aim of this study was set to evaluate the effects of a newly designed, EFA-enriched diet on the clinical signs of CAD compared to another EFA-enriched diet.

Materials and methods In this prospective, randomized, double-blinded study, 31 privately owned dogs with atopic dermatitis received either the control diet (diet A, Hill’s Prescription Diet™ d/d™ Salmon & Rice, n = 17) or the test diet (diet B, Veterinary HPM™ Dermatology Support D1, Virbac, n = 14) for 12 weeks. At the beginning of the study as well as after 4, 8 and 12 weeks, skin lesions and pruritus were evaluated via validated scores and the administered medication was documented. At the same time, the dogs’ coat quality was evaluated via a distinct scoring system. In both groups, a total of 7 dogs each completed the entire study.

Results After 12 weeks, there was a mild improvement in lesion scores, pruritus and coat quality with both diets.

Clinical relevance In this study, both diets improved the patients’ skin lesions pruritus and coat quality.

Zusammenfassung

Ziel Die kanine atopische Dermatitis ist eine häufige Hauterkrankung von Hunden. Frühere Studien zeigten positive Auswirkungen essenzieller Fettsäuren (EFA) auf die klinischen Symptome dieser Erkrankung. Ziel dieser Studie war es, die Wirkung einer neu konzipierten, mit EFA angereicherten Diät auf die klinischen Anzeichen der atopischen Dermatitis bei Hunden im Vergleich zu einer anderen mit EFA angereicherten Diät zu bewerten.

Material und Methoden In dieser prospektiven, randomisierten Doppelblindstudie erhielten 31 privat gehaltene Hunde mit atopischer Dermatitis entweder die Kontrolldiät (Diät A, Hill‘s Prescription Diet™ d/d™ Hundefutter mit Lachs und Reis, n = 17) oder die Testdiät (Diät B, Veterinary HPM™ Dermatology Support D1, Virbac, n = 14) über 12 Wochen. Zu Studienbeginn sowie nach 4, 8 und 12 Wochen wurden Hautläsionen und Juckreiz mit validierten Scores bewertet und die verabreichten Medikamente dokumentiert. Gleichzeitig erfolgte eine Beurteilung der Fellqualität der Hunde mit einem eigenen Scoring-System. In beiden Gruppen vollendeten jeweils 7 Patienten die komplette Studienphase.

Ergebnisse Nach 12 Wochen hatten sich die Läsionswerte und der Juckreiz sowie die Fellqualität mit beiden Futtern leicht verbessert.

Klinische Relevanz Beide Futter konnten in dieser Studie den Juckreiz, die Läsionen und die Fellqualität leicht verbessern.



Publication History

Received: 22 August 2020

Accepted: 04 January 2021

Article published online:
23 August 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Klinger CJ, Krause A, Rösch B. et al. Kleintiermedizin in Deutschland – Analyse des Fallaufkommens. Prakt Tierarzt 2016; 97: 774-787
  • 2 Lund EM, Armstrong PJ, Kirk CA. et al. Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States. J Am Vet Med Assoc 1999; 214: 1336-1341
  • 3 Scott DW, Paradis M. A survey of canine and feline skin disorders seen in a university practice: Small Animal Clinic, University of Montreal, Saint-Hyacinthe, Quebec (1987–1988). Can Vet J 1990; 31: 830-835
  • 4 Olivry T, DeBoer DJ, Griffin CE. et al. The ACVD task force on canine atopic dermatitis: forewords and lexicon. Vet Immunol Immunopathol 2001; 81: 143-146
  • 5 Favrot C, Steffan J, Seewald W. et al. A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol 2010; 21: 23-31
  • 6 Olivry T, Mueller RS. Evidence-based veterinary dermatology: a systematic review of the pharmacotherapy of canine atopic dermatitis. Vet Dermatol 2003; 14: 121-146
  • 7 Scott DW, Rothstein E, Miller WH. A clinical study on the efficacy of two commercial veterinary pramoxine cream rinses in the management of pruritus in atopic dogs. Can Pract 2000; 25: 15-17
  • 8 DeBoer DJ, Griffin CE. The ACVD task force on canine atopic dermatitis (XXI): antihistamine pharmacotherapy. Vet Immunol Immunopathol 2001; 81: 323-329
  • 9 Paterson S. Use of antihistamines to control pruritus in atopic dogs. J Small Anim Pract 1994; 35: 415-419
  • 10 Mueller RS, Fieseler KV, Fettman MJ. et al. Effect of omega-3 fatty acids on canine atopic dermatitis. J Small Anim Pract 2004; 45: 293-297
  • 11 Olivry T, Marsella R, Hillier A. The ACVD task force on canine atopic dermatitis (XXIII): are essential fatty acids effective?. Vet Immunol Immunopathol 2001; 81: 347-362
  • 12 Steffan J, Favrot C, Mueller RS. A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs. Vet Dermatol 2006; 17: 3-16
  • 13 Cosgrove SB, Wren JA, Cleaver DM. et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol 2013; 24: 479-e114 DOI: 10.1111/vde.12047.
  • 14 Michels GM, Ramsey DS, Walsh KF. et al. A blinded, randomized, placebo-controlled, dose determination trial of lokivetmab (ZTS-00103289), a caninized, anti-canine IL-31 monoclonal antibody in client owned dogs with atopic dermatitis. Vet Dermatol 2016; 27: 478-129
  • 15 Bond R, Lloyd DH. A double-blind comparison of olive oil and a combination of evening primrose oil and fish oil in the management of canine atopy. Vet Rec 1992; 131: 558-560
  • 16 Higgs GA. The effects of dietary intake of essential fatty acids on prostaglandin and leukotriene synthesis. Proc Nutr Soc 1985; 44: 181-187
  • 17 Logas D, Kunkle GA. Double-blinded Crossover Study with Marine Oil Supplementation Containing High-dose icosapentaenoic Acid for the Treatment of Canine Pruritic Skin Disease. Vet Dermatol 1994; 5: 99-104
  • 18 Schäfer L, Kragballe K. Supplementation with evening primrose oil in atopic dermatitis: effect on fatty acids in neutrophils and epidermis. Lipids 1991; 26: 557-560
  • 19 Scott DW, Miller WH, Decker GA. et al. Comparison of the clinical efficacy of two commercial fatty acid supplements (EfaVet and DVM Derm Caps), evening primrose oil, and cold water marine fish oil in the management of allergic pruritus in dogs: a double-blinded study. Cornell Vet 1992; 82: 319-329
  • 20 Scarff DH, Lloyd DH. Double blind, placebo-controlled, crossover study of evening primrose oil in the treatment of canine atopy. Vet Rec 1992; 131: 97-99
  • 21 Saevik BK, Bergvall K, Holm BR. et al. A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. Vet Dermatol 2004; 15: 137-145
  • 22 Glos K, Linek M, Loewenstein C. et al. The efficacy of commercially available veterinary diets recommended for dogs with atopic dermatitis. Vet Dermatol 2008; 19: 280-287 DOI: 10.1111/j.1365-3164.2008.00688.x.
  • 23 Nesbitt GH, Freeman LM, Hannah SS. Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus. Vet Dermatol 2003; 14: 67-74
  • 24 Hensel P, Santoro D, Favrot C. et al. Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification. BMC Vet Res 2015; 11: 196 DOI: 10.1186/s12917-015-0515-5.
  • 25 Plant JD, Gortel K, Kovalik M. et al. Development and validation of the Canine Atopic Dermatitis Lesion Index, a scale for the rapid scoring of lesion severity in canine atopic dermatitis. Vet Dermatol 2012; 23: 515-103 DOI: 10.1111/j.1365-3164.2012.01113.x.
  • 26 Rybnícek J, Lau-Gillard PJ, Harvey R. et al. Further validation of a pruritus severity scale for use in dogs. Vet Dermatol 2009; 20: 115-122
  • 27 Araujo JA, Studzinski CM, Larson BT. et al. Comparison of the cognitive palatability assessment protocol and the two-pan test for use in assessing palatability of two similar foods in dogs. Am J Vet Res 2004; 65: 1490-1496
  • 28 Marsella R, Sousa CA. The ACVD task force on canine atopic dermatitis (XIII): threshold phenomenon and summation of effects. Vet Immunol Immunopathol 2001; 81: 251-254
  • 29 Miller G. Dietary fatty acids and the haemostatic system. J Atherosclerosis 2005; 179: 213-227
  • 30 Boudreaux MK, Reinhart GA, Vaughn DM. et al. The effects of varying dietary n-6 to n-3 fatty acid ratios on platelet reactivity, coagulation screening assays, and antithrombin III activity in dogs. J Am Anim Hosp Assoc 1997; 33: 235-243
  • 31 Myers NC, Gross KL, Armstead EA. et al. The effect of dietary n-6: n-3 fatty acid ratio on hemostatic parameters and platelet aggregation in the dog. Proceedings of the American College of Veterinary Internal Medicine Annual Meeting; San Antonio, TX: 1996: 753
  • 32 Carrick JB, Schnellmann RG, Moore JN. Dietary source of omega-3 fatty acids affects endotoxin-induced peritoneal macrophage tumor necrosis factor and eicosanoid synthesis. Shock 1994; 2: 421-426
  • 33 Endres S, Ghorbani R, Kelley VE. et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989; 320: 265-271
  • 34 Rossetti RG, Seiler CM, Laposata M. et al. Differential regulation of human T lymphocyte protein kinase C activity by unsaturated fatty acids. J Clin Immunol Immunopathol 1995; 76: 220-224
  • 35 Lu L, Okada N, Nakatani S. et al. Eicosapentaenoic acid-induced changes in membrane fluidity and cell adhesion molecules in cultured human keratinocytes. Brit J Dermatol 1995; 133: 217-222
  • 36 Campbell KL, Dorn GP. Effects of oral sunflower oil and olive oil on serum and cutaneous fatty acid concentrations in dogs. Res Vet Sci 1992; 53: 172-178
  • 37 Mueller RS, Fettman MJ, Richardson K. et al. Plasma and skin concentrations of polyunsaturated fatty acids before and after supplementation with n-3 fatty acids in dogs with atopic dermatitis. Am J Vet Res 2005; 66: 868-873
  • 38 Marsh KA, Ruedisueli FL, Coe SL. et al. Effects of zinc and linoleic acid supplementation on the skin and coat quality of dogs receiving a complete and balanced diet. Vet Dermatol 2000; 11: 277-284
  • 39 Marsella R, Nicklin C, Lopez J. Studies on the role of routes of allergen exposure in high IgE-producing beagle dogs sensitized to house dust mites. Vet Dermatol 2006; 17: 306-312
  • 40 Bin P, Huang R, Zhou X. Oxidation Resistance of the Sulfur Amino Acids: Methionine and Cysteine. Biomed Res Int 2017 2017; 9584932 DOI: 10.1155/2017/9584932.
  • 41 Slominski A, Tobin DJ, Shibahara S. et al. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 2004; 84: 1155-1228