Planta Med
DOI: 10.1055/a-1542-8992
Reviews

The Influence of Turmeric and Curcumin on Female Reproductive Processes

Department of Zoology and Anthropology, Constantine the Philosopher University in Nitra, Nitra, Slovakia
› Author Affiliations
Supported by: Vedecká Grantová Agentúra MŠVVaŠ SR a SAV VEGA 13-ENV1321-02
Supported by: Agentúra na Podporu Výskumu a Vývoja APVV-15-0296

Abstract

The present review summarizes the available knowledge concerning the action of curcumin, the best-known polyphenol among the rhizomes of Curcumas, on female reproductive processes and their dysfunctions. Curcumin affects a number of physiological processes, including female reproduction (puberty, reproductive aging, ovarian follicullogenesis and oogenesis, and fecundity). Curcumin can affect these processes via changes in the release and reception of pituitary and ovarian hormones, growth factors and cytokines. Furthermore, it can influence the response of ovarian cells to these substances and external environmental factors. Finally, curcumin can affect oxidative processes within the ovary and numerous intracellular signalling pathways related to ovarian cell proliferation and apoptosis. These effects suggest the applicability of curcumin for stimulation of female reproductive processes in vivo and in vitro, as well as for the prevention, mitigation, and treatment of various reproductive disorders from ovarian insufficiency and infertility to polycystic ovarian syndrome and ovarian cancer.



Publication History

Received: 19 February 2021

Accepted after revision: 22 June 2021

Publication Date:
20 August 2021 (online)

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany