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DOI: 10.1055/a-1530-1128
Two New Cytotoxic Maytansinoids Targeting Tubulin from Trewia nudiflora
Authors
Gefördert durch: Shanghai Commission of Science and Technology 19495800800 Gefördert durch: National Natural Science Foundation of China 21672040 Gefördert durch: National Natural Science Foundation of China 82073717
Abstract
Two new maytansinoids, N-methyltreflorine (1) and methyltrewiasine (2), were isolated from the dried fruits of Trewia nudiflora, together with three known congeners (3 – 5). Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 and 2 was determined by X-ray crystallographic analysis. Compounds 1 – 5 exhibited strong cytotoxicity against human tumor cell lines, including HeLa, MV-4 – 11, and MCF-7, with IC50 values ranging from 0.12 to 11 nM. Compounds 1 and 4 also showed inhibitory activity against the MCF-7/ADR cell line with IC50 values of 13 and 28 nM, respectively. Compounds 1 and 2 significantly inhibited tubulin polymerization in vitro with IC50 values of 3.6 and 3.2 µM, respectively.
Supporting Information
- Supporting Information (PDF)
Detailed X-ray crystallographic data, IR, HRESIMS, and NMR spectra of 1 and 2, and the cytotoxicity and tubulin polymerization data are available as Supporting Information.
Publikationsverlauf
Eingereicht: 21. Februar 2021
Angenommen nach Revision: 02. Juni 2021
Artikel online veröffentlicht:
29. Oktober 2021
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