Drug Res (Stuttg)
DOI: 10.1055/a-1528-2721
Review

Recapitulation of Evidence of Phytochemical, Pharmacokinetic and Biomedical Application of Silybin

Anas Islam
1  Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Anuradha Mishra
1  Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Md Aftab Siddiqui
1  Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Saman Siddiquie
1  Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
› Author Affiliations

Abstract

Silymarin is a standardized extract obtained from seeds of Silybum marianum (SM) belonging to the family Asteraceae. It is a flavonolignan complex and consists of various compounds like silybin A silybin B, isosilybin A, isosilybin B, silydianin, silychristin and isosilychristin. Silybin is the major active component present in 60–70% of the silymarin extract. It has been used traditionally for the treatment of various liver disorders like cirrhosis, jaundice, and hepatitis. Silymarin possesses antioxidant and anti-inflammatory properties and is responsible for its antitumor activity. Other than hepatoprotective effect SM also possesses renoprotective, anti-diabetic, neuroprotective, hypolipidemic, anti-atherosclerosis and cardioprotective effects. Rather antimicrobial property of silymarin was observed against specific microbes, fungi, and viruses. This manuscript covered recent preclinical and clinical evidence of specific components silybin, responsible for its efficacy and about clinical studies has been conducted so far, which proven it’s safety and offers mild effect like nausea, diarrhea and bloating. This review specifically focused on recent updates on its active components therapeutic applications against complicated ailments not covered in earlier reports.



Publication History

Received: 23 April 2021

Accepted: 08 June 2021

Publication Date:
27 July 2021 (online)

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany