Drug Res (Stuttg) 2021; 71(08): 455-461
DOI: 10.1055/a-1527-1307
Original Article

Synthesis, Antimicrobial Evaluation of Substituted Indole and Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal Complexes

Preeti Sharma
1  Department of Chemistry, Bhagwant University, Ajmer Rajasthan, India
,
Varun Kumar Singh
2  Department of Chemistry, FoE, Teerthanker Mahaveer University, Moradabad Uttar Pradesh, India
,
2  Department of Chemistry, FoE, Teerthanker Mahaveer University, Moradabad Uttar Pradesh, India
› Author Affiliations

Abstract

Schiff base ligand (E)-5-methyl-3-(1-(4-nitrophenylimino)ethyl)-1H-indol-2-amine was synthesized by the condensation of 1-(2-amino-5-methyl-1H-indol-3-yl)ethanone and 4-nitrobenzenamine in methanol at 70 oC. The prepared Schiff base ligand doped with Cr(III), Mn(III) and Fe(III) ion, respectively and it is denoted as [M(C34H32N8O4)X]X2. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometry of the metal center was five coordinate square pyramidal. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential against Staphylococcus aureus, Bacillus subtilis (positive bacteria) and Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi (negative bacteria) and fungi Rizoctonia sp., Aspergillus sp., Penicillium sp. [Cr(C34H32N8O4)OAc](OAc)2 shows best antimicrobial activity against all the pathogens.



Publication History

Received: 27 March 2021

Accepted: 08 June 2021

Publication Date:
22 July 2021 (online)

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