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Z Geburtshilfe Neonatol 2021; 225(06): 506-512
DOI: 10.1055/a-1524-3373
Original Article

The Role of Delivery Route on Colostrum Melatonin and Serum Il-6 Levels: a Prospective Controlled Study

Canan Çalışkan
1   Obstetrics and Gynecology, Samsun Education and Research Hospital, Samsun, Turkey
,
Samettin Çelik
1   Obstetrics and Gynecology, Samsun Education and Research Hospital, Samsun, Turkey
,
Safak Hatirnaz
2   IVF Center, Medicana İnternational Hospital, Samsun, Turkey
,
Handan Çelik
3   Obstetrics and Gynecology, Ondokuz Mayis Universitesi, Samsun, Turkey
,
Bahattin Avcı
4   Biochemistry, Ondokuz Mayıs Üniversitesi Tıp Fakültesi, Samsun, Turkey
,
Andrea Tinelli
5   Department of Obstetrics and Gynecology, Veris delli Ponti” Hospital, Scorrano, Lecce, Italy, Lecce, Italy
› Author Affiliations Clinical trial registration Clinical Trials gov ID registration: NCT03953066
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Abstract

Introduction the aim of this study was to determine whether maternal serum IL-6 and postnatal melatonin levels change with the mode of delivery.

Materials and Methods a prospective controlled study was performed on pregnant women (17–43 years) over 37 weeks of pregnancy. Patients were divided into three groups according to the route of delivery: Group 1) 30 women delivering by vaginal route; Group 2) 30 delivering by iterative cesarean section (CS); Group 3) delivering by emergency CS. Maternal serum IL-6 levels were measured before and after delivery, and maternal colostrum melatonin levels after delivery, and the results between the 3 groups compared.

Results pre-delivery and post-delivery maternal serum IL-6 levels were significantly higher in patients who delivered vaginally than in patients who delivered by the abdominal route (p<0.01). Maternal colostrum melatonin levels of patients after delivery were significantly higher in patients who delivered vaginally (32.88±7.16 ng/L) than in patients who delivered by elective and emergent cesarean deliveries (24.86±2.40 ng/L and 23.73±4.03 ng/L, respectively) (p<0.01).

Conclusion These data support, should there ever be a further need, the benefit of vaginal delivery over cesarean section, in which cytokine and melatonin levels are reduced compared to vaginal delivery.

Key words

Interleukin 6 - melatonin - colostrum - vaginal delivery - cesarean section


Publication History

Received: 29 August 2020

Accepted after revision: 25 May 2021

Article published online:
16 December 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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