Effect of Exercise on Fatigue in Multiple Sclerosis Patients: A Network Meta-analysis

Yuting Chen; Shanshan Xu; Jiran Shen; Hui Yang; Wei Xu; Ming Shao; Faming Pan

doi:10.1055/a-1524-1935

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2021; 42(14): 1250-1259
DOI: 10.1055/a-1524-1935

Review

Effect of Exercise on Fatigue in Multiple Sclerosis Patients: A Network Meta-analysis

Autoren

Yuting Chen‡

¹Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, China

³The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China
Shanshan Xu‡

¹Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, China

³The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China
Jiran Shen

²Department of Internal Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

³The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China
Hui Yang

¹Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, China

³The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China
Wei Xu

¹Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, China

³The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China
Ming Shao

¹Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, China

³The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China
Faming Pan

¹Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, China

³The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China

Abstract

Few studies have directly compared the effects of different exercise therapies on reducing fatigue in patients with multiple sclerosis. Thus, we conducted a Frequentist network meta-analysis to analyze and compare the effectiveness of different types of exercise on reducing multiple sclerosis-related fatigue. Relevant randomized controlled trials were searched in PubMed, Web of Science and Cochrane Library databases from the date of their inception up to April 1, 2021. In total, 27 articles involving 1470 participants and 10 types of interventions met the inclusion criteria. The results indicated that aquatic exercise ranked as the most effective among these interventions, and aerobic exercise had small-to-moderate effect sizes. Most of the interventions were shown to be better than the control group, except for climbing. Climbing was the only intervention that ranked worse than the controls. All of these findings merit further investigation in future clinical trials.

Key words

multiple sclerosis - fatigue - exercise - training - ranking

Volltext

Referenzen

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