CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2021; 81(08): 940-947
DOI: 10.1055/a-1522-5178
GebFra Science

Intrahepatic Cholestasis of Pregnancy

Article in several languages: English | deutsch
Stanisław M. Jurk
1   Leipzig, Germany
Andreas E. Kremer
2   Medizinische Klinik 1, Universitätsklinikum Erlangen, Erlangen, Germany
3   Klinik für Gastroenterologie und Hepatologie, Universitätsspital Zürich, Zürich, Switzerland
Ekkehard Schleussner
4   Klinik für Geburtsmedizin, Universitätsklinikum Jena, Jena, Germany
› Author Affiliations


Intrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intrahepatic cholestasis should always be managed in a perinatal centre with close interdisciplinary monitoring and treatment involving perinatologists and hepatologists to minimise the markedly increased perinatal morbidity and mortality as well as maternal symptoms.

Publication History

Received: 19 June 2020

Accepted after revision: 02 June 2021

Publication Date:
09 August 2021 (online)

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